Changsheng Wu

Release date:2019-08-08    Author:     Editor: liyuan    Click:



office:room309, building N1


2011.09-2015.08,Leiden University,molecular biotechnology,PhD;

2008.09-2011.06,Shandong University,natural products chemistry,Master;

2004.09-2008.06,Shandong University,pharmacy,Bachelor。

Working Experience

2018.7-present,State Key Laboratory of Microbial Technology, Shandong University,professor;

2017.04-2019.05,Laboratory of Genetically Encoded Small Molecules,Rockefeller University,postdoctor;

2015.09-2017.02,Institute of Biology,Leiden University,postdoctor;

Research fields

1. Discovery of novel natural products from microbial resources

2. Biosynthesis and bioengineering of novel microbial products

Research Projects

Rubicon grant from Netherlands Organisation for Scientific Research(019.163LW.018)

Honors and awards

1.“Cum Laude”of Leiden university, 2015

2.“c.j.kok jury award”of Leiden university, 2017

Publication list

1.Zhang, P.; Zhang, Z.; Li, Z. F.; Chen, Q.; Li, Y. Y.; Gong, Y.; Yue, X. J.; Sheng, D. H.; Zhang, Y. M.;Wu,C.*; Li, Y. Z.* Phylogeny-guided Characterization of Glycosyltransferases for Epothilone Glycosylation.Microbiol. Biotech.2019, doi.org/10.1111/1751-7915.13421. (*co-corresponding)

2.Wu, C.#; ShangZ.#; Lemetre C.; Ternei M. A. ;Brady S. F.;Cadasides, calcium-dependent acidic lipopeptides from the soil metagenome that are active against multidrug resistant bacteria.J. Am. Chem. Soc.2019,141, 3910-3919. (#co-first author)

3.Machushynets N.;Wu, C. *; Elsayed S. S.; Hankemeier T.; van Wezel G. P. * Discovery of novel glycerolated quinazolinones fromStreptomyces sp. MBT27.J. Ind. Microbiol. Biotechnol. 2019.46, 483-492. (*co-corresponding)

4.Wu, C.; van der Heul, H.U.; Melnik, A. V.; Luebben, J.; Pannu, N.; Dorrestein, P. C.; Choi, Y. H.; van Wezel, G. P. Lugdunomycin, an angucycline-derived molecule with unprecedented chemical architecture.Angew. Chem. Int. Ed.2019,58,2809 –2814.

5. Wu, C.; Du, C.; Ichinose, K.;Choi, Y. H.; van Wezel, G. P. Discovery ofC-glycosylpyranonaphthoquinones inStreptomyces sp. MBT76 by a combined NMR-based metabolomics and bioinformatics workflow. J. Nat. Prod. 2017, 80, 269–277.

6. Gubbens, J.; Wu, C.;Zhu, H.;Filippov,D. V.;Florea, B. L.;Rigali, S.;Overkleeft, H. S.; van Wezel, G. P. Intertwined Precursor Supply during Biosynthesis of the Catecholate–Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76.ACS Chem. Biol.2017,12, 2756–2766.

7. Wu, C.; Ichinose, K.;Choi, Y. H.; van Wezel, G. P. Aromatic Polyketide GTRI-02 is a previously unidentified product of the act gene cluster inStreptomyces coelicolor A3(2).ChemBioChem.2017, 18, 1428–1434.

8.Wu, C.; Medema, M. H.; Läkamp, R. M.; Zhang, L.; Dorrestein, P. C.; Choi, Y. H.; van Wezel, G. P. Leucanicidin and Endophenasides Result from Methyl-Rhamnosylation by the Same Tailoring Enzymes inKitasatospora sp. MBT66.ACS Chem. Biol. 2016,11, 478–490.

9.Wu, C.#; Zhu, H.#; van Wezel, G. P.; Choi, Y. H. Metabolomics-guided analysis of isocoumarin production by Streptomyces species MBT76 and biotransformation of flavonoids and phenylpropanoids.Metabolomics 2016, 12:90. (#co-first author)

10. Wu, C.; Choi, Y. H.; van Wezel, G. P. Metabolic profiling as a tool for prioritizing antimicrobial compounds.J. Ind. Microbiol. Biotechnol.2016,43, 299–312.

11.Wu, C.; Du, C.; Gubbens, J.; Choi, Y. H.; van Wezel, G. P. Metabolomics-Driven Discovery of a Prenylated Isatin Antibiotic Produced byStreptomyces Species MBT28.J. Nat. Prod.2015,78, 2355–2363.

12. Wu, C.; Kim, H. K.; van Wezel, G. P.; Choi, Y. H. Metabolomics in the natural products field – a gateway to novel antibiotics.Drug Discov. Today Technol.2015,13, 11–17.

13. Wu, C.; Zacchetti, B.; Ram, A. F. J.; van Wezel, G. P.; Claessen, D.; Choi, Y. H. Expanding the chemical space for natural products byAspergillus-Streptomyces co-cultivation and biotransformation.Sci. Rep.2015,5, 10868.

14.Wu, C.; van Wezel, G. P.; Choi, Y. H. Identification of novel endophenaside antibiotics produced byKitasatospora sp. MBT66.J. Antibiot. (Tokyo).2015,68, 445–452.

15. Zheng, L.; Wang, M.; Ibarra-Estrada, E.; Wu, C.; Wilson, E.; Verpoorte, R.; Klinkhamer, P.; Choi, Y. H. Investigation of Chemomarkers of Astragali Radix of Different Ages and Geographical Origin by NMR Profiling. Molecules2015,20, 3389–3405.

16. Yuan, C.; Li, G.;Wu, C.; Wang, H.; Zhao, Z.; Lou, H. A New Fatty Acid from the Endolichenic FungusMassarina sp.Chem. Nat. Compd.2015,51, 415–417.

17. Zhu, H.; Swierstra, J.;Wu, C.; Girard, G.; Choi, Y. H.; Van Wamel, W.; Sandiford, S. K.; van Wezel, G. P. Eliciting antibiotics active against the ESKAPE pathogens in a collection of actinomycetes isolated from mountain soils. Microbiology2014,160, 1714–1726.

18. Yuan, C.; Wang, H.;Wu, C.; Jiao, Y.; Li, M.Wang, Y.; Wang, S.; Zhao, Z.; Lou, H.Austdiol, fulvic acid and citromycetin derivatives from an endolichenic fungus,Myxotrichum sp.Phytochem. Lett.2013,6, 662–666.

19.Wu, C.; Lin, Z.; Wang, L.; Guo, D. Phenolic Compounds with NF-κB Inhibitory Effects from the FungusPhellinus baumii.Bioorg. Med. Chem. Lett. 2011,21, 3261–3267.

20. Wang, L.; Guo, D.; Wang, S.; Wu, C.; Rehman, M. U.; Lou, H. Phenolic Glycosides from the Chinese LiverwortReboulia hemisphaerica.Helv. Chim. Acta 2011,94, 1146–1152.


Wu, C.; Choi, Y. H.; van Wezel, G. P. Methods of preparation and use of novel polyketides. EuropeanPatentApplication.WO 2016195495

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