Tingting Guo

Release date:2019-06-24    Author:     Editor: liyuan    Click:








Shandong University




Shandong University

Biological science

Research Experience





Microbial technology institute, Shandong University

Associate Professor


Microbial technology institute, Shandong University



School of life science, Shandong University


Research Interests

1. Bacteriophage of lactic acid bacteria and the potential application

2. Physiological genetics research of lactic acid bacteria

3 Gut lactic acid bacteria

Research Projects

1. 2017.7-2020.12Exploitation of intestinal probiotics resource based on Chinese people and dietary features.National Key Research and Development Program of China. Participant

2. 2015.01-2017.12 Genome editing technology in lactic acid bacteria using CRISPR/Cas system.National Science Foundation for Young Scientists of China. Host

3. 2015.07-2017.12 Construction and potential application of highly active and broad-spectrum antimicrobial developed from phage endolysin.China Postdoctoral Science FoundationSpecial Project. Host

4. 2014.07-2016.12 Oligomeric state and lysis control mechanism of holin protein ofLactobacillus bacteriophage.China Postdoctoral Science Foundation Funded GeneralProject. Host

Representative Publications

1. Yongping Xin#, Yingli Mu, Jian Kong, Tingting Guo*. 2019. Targeted and repetitive chromosomal integration enables high yield of heterologous gene expression inLactobacillus casei,Appl Environ Microbiol 85:e00033-19.

2.Tingting Guo#, Yongping Xin#, Yi Zhang, Xinyi Gu, Jian Kong*. 2019. A rapid and versatile tool for genomic engineering inLactococcus lactis.Microb Cell Fact 18:22.

3.Tingting Guo#, Yongping Xin, Chenchen Zhang, Jian Kong*. 2018. A cytoplasmic antiholin is embedded in-frame with the holin in aLactobacillus fermentum bacteriophage.Appl Environ Microbiol 84:e02518-17.

4.Tingting Guo#, Li Zhang, Yongping Xin, Zhenshang Xu, Huiying He, Jian Kong*. 2017 Oxygen-Inducible Conversion of Lactate to Acetate in HeterofermentativeLactobacillus brevis ATCC 367. Appl Environ Microbiol 83:e01659-17.

5.Tingting Guo#, Xudong Ouyang, Yongping Xin, Yue Wang, Susu Zhang, Jian Kong*. 2016. Characterization of a New Cell Envelope Proteinase PrtP from Lactobacillus rhamnosus CGMCC11055.J Agric Food Chem, 2016, 64(37): 6985-6992.

6. Tingting Guo#, Chenchen Zhang, Yongping Xin, Min Xin, Jian Kong*. 2016. A novel chimeric prophage vB_LdeS phiJB from commercial Lactobacillus delbrueckii subsp. bulgaricus.J Ind Microbiol Biotechnol 43(5):681-689.

7.Tingting Guo#, Yongping Xin, Chechen Zhang, Xudong Ouyang, Jian Kong*. 2016. The potential of the endolysin Lysdb fromLactobacillus delbrueckii phage for combatingStaphylococcus aureus during cheese manufacture from raw milk.Appl Microbiol Biotechnol 100(8):3545-54.

8. Tingting Guo#, Chenchen Zhang, Wei Liu, Shaohua Wang, Jian Kong*. 2015. Functional analysis of the N-terminal region of endolysin Lyb5 encoded byLactobacillus fermentum bacteriophage φPYB5.Int J Food Microbiol 203:1-7.


1 Jian Kong, Tingting Guo, Chenchen Zhang, Liying Han, Ting Wang;The invention relates to a preparation method, product and application of a liquid yogurt starter;patent number: ZL201410475760.8

2 Jian Kong, Tingting Guo, Ting Wang, Xiaotong Gao;AStreptococcus thermophilus withγ-aminobutyric acid and glutathione synthesis ability and its application;patent number: ZL201410480097.0

3 Jian Kong, Tingting Guo, Xudong Ouyang, Yongping Xin;ALactobacillus rhamnosus with cell membrane protease and its application; patent number: ZL20151064605.5.

Adress:State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China

Tel: (86)-0532-58631501  (86)-0532-58631597  Post Code: 266237

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