Pingyi Li

Release date:2019-06-24    Author:     Editor: liyuan    Click:








Sep. 2006-Dec. 2011

Shandong University



Sep. 2002-July 2006

Shandong University


Research Experience




Jun. 2018-present

State Key Laboratory of Microbial Technology, Shandong University

Associate Professor

Jul. 2016-May2018

Institute of Marine Science and Technology,Shandong University

Associate Professor

Feb. 2012-Dec. 2015

School of Chemistry and Chemical Engineering, Shandong University

Post doctor


Research Interests

1.Structural and functional analysesof new enzymes involved inmarine organic carbon degradation

2.Physiological and genetic analyses of marine unculturable microorganisms


Research Projects

1. Jan. 2018-Dec. 2020, The catalytic mechanism of phospholipase PlcP and the role of PlcP in marine carbon and phosphorus cycles, National Natural Science Foundation of China (91751101),principal investigator.

2. Jan. 2017-Dec. 2020, Catalytic mechanism and physiological function of a novel two-domain esterase containing an OsmC domain, National Natural Science Foundation of China (41676180),principal investigator.

3. Aug. 2013-Aug. 2015, Carbon sources and energy metabolism of theunculturableMCG crenarchaea revealed by analysis of BAC libraries,China postdoctoral science foundation(2013M53158), principal investigator.


Representative Publications

1.Yue Wang1,Ping-Yi Li1, Yi Zhang, Hai-Yan Cao, Yan-Jun Wang, Chun-Yang Li, Peng Wang, Hai-Nan Su, Yin Chen, Xiu-Lan Chen*, Yu-Zhong Zhang*.3,6-anhydro-L-galactose dehydrogenase VvAHGD is a member of a new aldehyde dehydrogenase family and catalyzes by a novel mechanism with conformational switch of two catalytic residues cysteine 282 and glutamate 248. Journal of Molecular Biology, 2020, doi: 10.1016/j.jmb.2020.02.008

2.Ping-Yi Li1, Yan-Qi Zhang1, Yi Zhang1, Wen-Xin Jiang, Yan-Jun Wang, Yi-Shuo Zhang, Zhong-Zhi Sun, Chun-Yang Li, Yu-Zhong Zhang, Mei Shi, Xiao-Yan Song,Long-Sheng Zhao*, Xiu-Lan Chen*.Study on a novel cold-active and halotolerant monoacylglycerol lipase widespread in marine bacteria reveals a new group of bacterial monoacylglycerol lipases containing unusual C(A/S)HSMG catalytic motifs.Frontiers in Microbiology, 2020, 11:9

3.Yan-Jun Wang1, Wen-Xin Jiang, Yi-Shuo Zhang, Hai-Yan Cao, Yi Zhang,Xiu-Lan Chen, Chun-Yang Li, Peng Wang, Yu-Zhong Zhang, Xiao-Yan Song*,Ping-Yi Li*. Structural insight into chitindegradation and thermostability of anovel endochitinase from theglycoside hydrolase family 18. Frontiers in Microbiology, 2019, 10:2457

4. Xiu-Lan Chen1, Fang Zhao1, Yong-Sheng Yue, Xi-Ying Zhang, Yu-Zhong Zhang,Ping-Yi Li*.A new group of modular xylanases in glycoside hydrolasefamily 8 from marine bacteria. Applied and Environmental Microbiology, 2018, 84: e01785-18

5.Ping-Yi Li1, Qiong-Qiong Yao1, Peng Wang, Yi Zhang, Yue Li, Yan-Qi Zhang, Jie Hao, Bai-Cheng Zhou, Xiu-Lan Chen*, Mei Shi, Yu-Zhong Zhang, Xi-Ying Zhang*. A novel subfamily esterase with a homoserine transacetylase-like fold but no transferase activity. Applied and Environmental Microbiology, 2017, 83:e00131~17

6.Ping-Yi Li1, Yi Zhang1, Bin-Bin Xie*, Yan-Qi Zhang, Jie Hao, Yue Wang, Peng Wang,Chun-Yang Li, Qi-Long Qin, Xi-Ying Zhang, Hai-Nan Su, Mei Shi, Yu-Zhong Zhang, Xiu-Lan Chen*. Structural andmechanisticinsights into theimprovement of thehalotolerance of amarinemicrobialesterase byincreasingintra- andinterdomainhydrophobicinteractions. Applied and Environmental Microbiology, 2017, 83: e01286~17

7. Yi Zhang1, Jie Hao, Yan-Qi Zhang, Xiu-Lan Chen, Bin-Bin Xie, Mei Shi, Bai-Cheng Zhou, Yu-Zhong Zhang,Ping-Yi Li*. Identification and characterization of a novel salt-tolerant esterase from the deep-sea sediment of the South China Sea, Frontiers in Microbiology, 2017, 8: 441

8. Fei Xu1, Fang Dong, Peng Wang, Hai-Yan Cao,Chun-Yang Li,Ping-Yi Li, Xiu-Hua Pang, Yu-Zhong Zhang, Xiu-Lan Chen*. Novel molecular insights into the catalytic mechanism of marine bacterial alginate lyase AlyGC from polysaccharide lyase family 6.Journal of Biological Chemistry, 2017, 292: 4457~4468

9.Ping-Yi Li1, Xiu-Lan Chen, Peng Ji, Chun-Yang Li, Peng Wang, Yi Zhang, Bin-Bin Xie, Qi-Long Qin, Hai-Nan Su, Bai-Cheng Zhou, Yu-Zhong Zhang, Xi-Ying Zhang*. Interdomain hydrophobic interactions modulate the thermostability of microbial esterases from the hormone-sensitive lipase family, Journal of Biological Chemistry, 2015, 290(17): 11188~11198

10.Ping-Yi Li1, Peng Ji, Chun-Yang Li, Yi Zhang, Guang-Long Wang, Xi-Ying Zhang, Bin-Bin Xie, Qi-Long Qin, Xiu-Lan Chen, Bai-Cheng Zhou, Yu-Zhong Zhang*. Structural basis for dimerization and catalysis of a novel esterase from the GTSAG motif subfamily of the bacterial hormone-sensitive lipase family, Journal of Biological Chemistry, 2014, 289(27): 19031~19041

11. Bing Guo1,Ping-Yi Li1, Yong-Sheng Yue, Hui-Lin Zhao, Sheng Dong, Xiao-Yan Song, Cai-Yun Sun, Wei-Xin Zhang, Xiu-Lan Chen, Xi-Ying Zhang*. Bai-Cheng Zhou, Yu-Zhong Zhang, Gene cloning, expression and characterization of a novel xylanase from the marine bacterium,Glaciecola mesophilaKMM241, Marine Drugs, 2013, 11(4): 1173~1187

12.Ping-Yi Li1, Bin-Bin Xie*, Xi-Ying Zhang, Qi-Long Qin, Hong-Yue Dang, Xu-Min Wang, Xiu-Lan Chen, Jun Yu, Yu-Zhong Zhang*. Genetic structure of three fosmid-fragments encoding 16S rRNA genes of the Miscellaneous Crenarchaeotic Group (MCG): implications for physiology and evolution of marine sedimentary archaea, Environmental Microbiology, 2012, 14(2): 467~479



1. 一种海洋适冷酯酶及其编码基因E40与应用,ZL201510025698.7,第二位。

2. 一种海洋酯酶及其编码基因E32与应用,ZL201510216087.0,第二位。

Adress:State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China

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