Education

Degree	Date	Affiliation	Major
PhD	September 2000-July 2004	Shandong University	Developmental biology
Master	September 1991-July 1994	Shandong Normal University	Molecular genetics
Bachelor	September 1987-July1991	Shandong Normal University	Biology

Research Experience

Date	Affiliation	Position
September 2014-present	Shandong University	Professor
September 2006-August 2013	Shandong University	Associate professor
September 1996-August 2006	Shandong University	Lecturer

Research Interests

1. Gastrointestinal dysbacteriosis and tumorigenesis: The process involved ininfection of pathogenic bacteria and their roles in carcinogenesis

2. Gastrointestinal bacteria and tumor immunity: the inflammatory microenvironment and microbiome in development of gastric and colorectal carcinoma

3. Gut microbiota-associated metabolic disease: the interactions between gut microbiota and host metabolism, and the biological properties of these metabolites with impact on the human health

Research Projects

1. National key research and development program "The mechanism of marine biogenic gas cycle involved in microorganism".(2016-2020,(NO. 2016YFA0601303, RMB:3800,000). Role: PI.

2. National Natural Science Foundation of China:“Catalytic properties of a novel deep-sea esterase EstD and its mechanism to adapt to the deep sea cold environment”. (2017-2021,NO.31670497, RMB:620,000).Role: PI.

3. National Natural Science Foundation of China:“Classification and diversity of the protease-producing bacteria and diversity of their extracellular proteases and ecological adaptation”. (2015-2018,NO. 31470541, RMB:800,000).Role: PI.

4. National Natural Science Foundation of China:“The nano-scale superamolecular structure of the cell wall of antibiotic resistantStaphylococcus aureus and the antimicrobial mechanism of pseudoalterin”. (2013-2016,NO. 81271896, RMB:700,000). Role: PI.

5. National Natural Science Foundation of China:“The mechanism of target therapy involved in autophagic programmed cell death induced by antimicrobial peptaibols”. (2011-2013,NO. 81071804, RMB:330,000).Role: PI.

6. National Natural Science Foundation of China:“The structure, properties and antitumor mechanisminvolved in antimicrobial peptaibols”. (2009-2011,NO. 30870047, RMB:330,000).Role: PI.

7.National High-tech R&D Program of China (863 Program) China (863 Program): “Pilot-scale Study onpeptaibols, aantimicrobial peptideSecreted byTrichoderma koningii”. (2007-2010, NO. 2007AA091504,RMB:1910,000). Role:PI.

Representative Publications

1.Li DD, Peng M, Wang N, Wang XJ, Zhang XY, Chen XL, Su HN, Zhang YZ,Shi M*. Arcticibacterium luteifluviistationis gen. nov., sp. nov., isolated from Arctic seawater. Int J Syst Evol Microbiol, 2017, 67:664-669.

2.Li DD, Liu C, Zhang YQ, Wang XJ, Wang N, Peng M, Song XY, Su HN, Zhang XY, Zhang YZ,Shi M*. Flavobacterium arcticum sp. nov., isolated from Arctic seawater. Int J Syst Evol Microbiol, 2017, 67:1070-1074.

3. Wang N, Xu F, Zhang XY, Chen XL, Qin QL, Zhou BC, Zhang YZ,Shi M*. Changchengzhania lutea gen. nov., sp. nov., a new member of the family Flavobacteriaceae isolated from Antarctic intertidal sediment. Int J Syst Evol Microbiol, 2017,67:5187-5192.

4. Zhang XY, Han XX, Chen XL, Dang HY, Xie BB, Qin QL,Shi M*, Zhou BC, Zhang YZ. Diversity of cultivable protease-producing bacteria in sediments of Jiaozhou Bay, China. Front Microbiol, 2015, 6:1021.

5. Liu C, Zhang XY, Song XY, Su HN, Qin QL, Xie BB, Chen XL, Zhang YZ,Shi M*. Algimonas arctica sp. nov., isolated from intertidal sand, and emended description of the genus Algimonas. Int J Syst Evol Microbiol, 2015, 65:3256-3261.

6. Xu Z, Zhang XY, Su HN, Yu ZC, Liu C, Li H, Chen XL, Song XY, Xie BB, Qin QL, Zhou BC,Shi M*, Huang Y, Zhang YZ. Oceanisphaera profunda sp. nov., a marine bacterium isolated from deep-sea sediment, and emended description of the genus Oceanisphaera. Int J Syst Evol Microbiol, 2014, 64(Pt 4):1252-1256

7. Liu C, Zhang XY, Su HN, Zhou MY, Chen B, Li H, Chen XL, Zhao DL, Zhou BC,Shi M*, Zhang YZ. Puniceibacterium antarcticum gen. nov., sp. nov., isolated from seawater. Int J Syst Evol Microbiol, 2014, 64(Pt 5):1566-1572.

8. Li H, Zhang XY, Liu C, Lin CY, Xu Z, Chen XL, Zhou BC,Shi M*, Zhang YZ. Polaribacter huanghezhanensis sp. nov., isolated from Arctic fjord sediment, and emended description of the genus Polaribacter. Int J Syst Evol Microbiol, 2014, 64(Pt 3):973-978.

9. Shi M, Zhang T, Sun L, Luo Y, Liu DH, Xie ST, Song XY, Wang GF, Chen XL, Zhou BC, Zhang YZ. Calpain, Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium. Apoptosis, 2013, 18:435-451.

10. Shi M, Chen L, Wang XW, Zhang T, Zhao PB, Song XY, Sun CY, Chen XL, Zhou BC, Zhang YZ. Antimicrobial peptaibols from Trichoderma pseudokoningii induce programmed cell death in plant fungal pathogens. Microbiology,2012, 158(Pt 1):166-175.

11. Shi M, Wang HN, Xie ST, Luo Y, Sun CY, Chen XL, Zhang YZ. Antimicrobial peptaibols, novel suppressors of tumor cells, targeted calcium-mediated apoptosis and autophagy in human hepatocellular carcinoma cells.Mol Cancer, 2010,9:26-41.

12.Luo Y, Zhang DD, Dong XW, Zhao PB, Chen LL, Song XY, Wang XJ, Chen XL,Shi M*, Zhang YZ. Antimicrobial peptaibols induce defense responses and systemic resistance in tobacco against tobacco mosaic virus. FEMS Microbiol Lett, 2010, 313:120-126.

13. Shi M, Yan SG, Xie ST, Wang HN. Tip30-induced apoptosis requires translocation of Bax and involves mitochondrial release of cytochrome c and Smac/DIABLO in hepatocellular carcinoma cells.Biochim Biophys Acta, 2008, 1783:263-274.