Education
Degree |
Date |
Affiliation |
Major |
PhD |
2000.9-2003.6 |
School of Life Science, Shandong University |
Microbiology |
Master |
1997.9-2000.6 |
School of Life Science,Shandong University |
Microbiology |
Bachelor |
1993.9-1997.6 |
Department of Microbiology,Shandong University |
Microbiology |
Research Experience
Date |
Affiliation |
Position |
2010.12- present |
State Key Laboratory of Microbial Technology,Shandong University |
Professor, PhD supervisor |
2008.01-2009.01 |
Division of Pharmaceutical Sciences,University of Wisconsin-Madison |
Postdoctoral Fellow, |
2005.09-2010.11 |
State Key Laboratory of Microbial Technology, Shandong University |
Associate Professor |
2003.07-2005.08 |
State Key Laboratory of Microbial Technology, Shandong University |
Assistant Professor |
Research Interests
1. Molecular evolution and synthetic biology of edible and medicinal microbiology, especialy pharmacology and toxicology evaluation for anticancer and anti-infective products from fungi.
2. Exploitation of environmental microorganisms and microbial products for environmental pollution control and bioremediation; Novel biological technologies for organic pollutants control; Theory and technology for biodegradation and bioremediation of environmental pollutants; Harmful microorganisms control for safety- reuse of reclaimed water;
3. Structure-activity relationship of functional food factor, safety evaluation, and separation and detection technology; Safety and quality control of fermented food;
Research Projects
1.Evaluation of germplasmresource of Cordyceps kyushuensis based on metabonomicstechnology and transcriptomics, proteomic research of Cordycepinbiosynthesis. NSFC
2. Fundamental research on germ plasm resources of Cordyceps kyushuensis by somatic hybridization and mutation breeding method. NSFC
3. Study on theidentification ofanamorph and thematerialbase ofanti-tumor of Cordyceps kyushuensins. NSFC
4.Development of functional probiotics for the intestinal health and nutrient regulation of chicken. National Sci-Tech Support Program of China:
5.Evaluation of germplasmresource of Cordyceps kyushuensis based on metabonomicstechnology. Science Foundation of Shandong Province
6.Research on detection technology of heavy metal and pesticide residues in Chinese herbal medicine. DevelopmentProjects of ShandongProvinceScience andTechnology.
7.Study on degradation of azo dyes wastewater by combined use of microbial and immobilized nanomete TiO2. InterdisciplineCultivationProject of Shandong University
8. Bioinformatics research on TIPE2 key regulation gene of HBV infection and molecular mechanism. Interdiscipline cultivation project of Shandong University
9. Process research and development of healthy drink series of Cordyceps. Crossing research project.
10.Industrialization of Flammulin protein products. Crossing research project.
Representative Publications
1. Cordycepin and pentostatinbiosynthesis gene identified through transcriptome and proteomics analysis of Cordyceps kyushuensisKob. Microbiological Research.2018,https://doi.org/10.1016/j.micres. 2018.09.005.
2. Aqueous extracts of CordycepskyushuensisKobinduce apoptosis to exert anticancer activity.BioMed Research International.2018, https://doi.org/10.1155/2018/8412098.
3.Cordycepin induces autophagy-mediated c-FLIPL degradation and leads to apoptosis in human non-small cell lung cancer cells.Oncotarget. 2017, 8(4): 6691-6699.
4.Genome shuffling improved the nucleosides production in Cordycepskyushuensis. Journal of Biotechnology. 2017, 260 (1): 42-47.
5. Antioxidant property prediction of methanol extracts of crude drug based on near infrared spectroscopy. Spectroscopy and Spectral Analysis. 2017, 37(8): 2402 -2405.
6.Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic. PNAS2015, 112 (49): 15084-15089.
7. Purification and antioxidant effect of novel fungal polysaccharides from the stroma of Cordyceps kyushuensis. Industrial Crops and Products 2015, (69): 485-491.
8. Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells. Cell Cycle. 2015, 14(5):761-771.
9. Physicochemical characteristics of epichlorohydrin, pyridine and trimethylamine functionalized cotton stalk and its adsorption/desorption properties for perchlorate. Journal of Colloid and Interface Science. 2015, (440):219-228.
10. Photocatalyis of THM precursors in reclaimed water: the application of TiO2 in UV irradiation. Desalination and Water Treatment 10.1080/19443994. 2015. 1030710.
11. Column adsorption of perchlorate by amine-crosslinked biopolymer based resin and its biological, chemical regeneration properties.Carbohydrate Polymers. 2015, (115): 432-438.
12.Determination of essential and toxic elements in Cordyceps kyushuensis Kawam by inductively coupled plasma mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2013, (72):172-176.
13. Isolation and characterization of a novel pyrene-degrading Bacillus vallismortis strain JY3A. Science of the Total Environment. 2011, 09(10):1994-2000.
14. Analysis and evaluation of different radial parts of Cordyceps kyushuensis by fourier transform infrared spectroscopy. Spectroscopy and Spectral Analsis. 2011, 31 (9): 2420-2423.
15. Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate. Journal of the American Chemical Society. 2010, (132): 12534-12536.
Honors and awards
1. Science andtechnologyprogressaward of ShandongProvince in 2014, 2nd class. First winner
2. The innovative and entrepreneurial talent of Jiangsu Province in 2017
3. The 5150 Program Talents of Jinan City in 2017
4.The innovative and entrepreneurial talent of Xuzhou City in 2016
Patents
Linget al. A method for extractingpolysaccharide-grifolin from Grifola frondosa.
No. 201610802778.3.
