Shengying Li

Release date:2020-03-31    Author:     Editor: liyuan    Click:










University of Michigan

Medicinal Chemistry



Xiamen University




Xiamen University



Research Experience





State Key Laboratory of Microbial Technology, Shandong University



Shandong Provincial Key Laboratory of Synthetic Biology



Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences



Life Sciences Institute, University of Michigan

Postdoctoral Research Fellow


Alluvium Biosciences Inc.

Research Scientist


Research Interests

Biosynthetic P450 enzymes;

Natural product biosynthesis;

Industrial Strain Improvement.


Research Projects

1. 01/2020-12/2024 Screening and identification of plastic-degrading bacteria/enzymes (合成塑料高效生物降解的关键技术-课题一-合成塑料降解菌/酶的筛选及鉴定), The Ministry of Science and Technology of China (国家重点研发计划项目,2019YFA0706901)

2. 12/2019-12/2024 Rational design of cytochrome P450 enzymes for selective oxidation of C-H bonds (碳-氢键选择性氧化P450酶的人工设计), Department of Science and Technology, Shandong Province (山东省自然科学基金重大基础研究项目,ZR2019ZD20)

3. 01/2019-12/2022Construction of Artificial Yeast Liver to accurately mimic the physiological behaviors of human liver cytochrome P450 monooxygenases (创建精准模拟人类肝脏CYPs生理行为的酵母人工肝),National Natural Science Foundation of China (面上项目,NSFC 31872729)

4. 03/2018-02/2020Microbial cell factories for fatty acid derivatives by cytochrome P450 enzymes coupled to unnatural cofactors (耦合非天然辅酶的P450脂肪酸衍生细胞工厂,大连化物所—青岛能源所融合基金, DICP&QIBEBT UN201706)

5. 08/2017-07/2019Biosynthetic Pathway Reconstruction ofHigh-value Natural ProductBased onP450CatalyticElements (基于P450催化元件的高值天然产物生物合成途径重构), Department of Science and Technology, Shandong Province (山东省自然科学基金重大基础研究项目, ZR2017ZB0207)

6. 09/2017-09/2019Proof of Concept of Pathway Integration forα-Olefin Biosynthesis in Photosynthetic Microorganisms, TOTAL, Research Program Agreement between TOTAL Marketing Services and QIBEBT(国际合作项目)

7. 01/2018-12/2018Deep Mining of Bioactive Natural Products from a Tropical Marine Streptomyces Strain (一株热带海洋链霉菌活性天然产物资源的深度挖掘),National Natural Science Foundation of China (应急管理项目,NSFC81741155)

8. 01/2016-12/2020Rational design of cytochrome P450 enzymes for selective oxidation of C-H bonds (碳-氢键选择性氧化P450酶的人工设计研究, 中科院前沿科学重点研究计划, QYZDB-SSW-SMC042)

9. 10/2015-03/2017Improving C12 activity of new decarboxylase encoding sequences, TOTAL, Research Program Agreement between TOTAL Marketing Services and QIBEBT(国际合作项目)

10. 01/2015-12/2017Biosynthesis of Microbial Secondary Metabolites (微生物次级代谢产物生物合成), National Natural Science Foundation of China (优秀青年基金项目,NSFC 31422002)

11. 01/2015-12/2018Biosynthetic Mechanisms and Synthetic Biology of Fungal Alkaloid Brevianamides (真菌生物碱Brevianamides的生物合成机制与合成生物学研究), National Natural Science Foundation of China (面上项目,NSFC 21472204)

12. 01/2015-12/2017Microbial Biosynthesis (微生物生物合成), Department of Science and Technology, Shandong Province (山东省杰出青年基金项目, JQ201407)

13. 10/2013-09/2014Production of α-alkenes with aviation fuel properties inEscherichia coli, BOEING, QIBEBT Collaboration Agreement for a Joint Research Laboratory for Sustainable Aviation Biofuels(国际合作项目)

14. 01/2013-12/2016Studies on Enzymology, Bioengineering and Combinatorial Biosynthesis of A P450 Fatty Acid Decarboxylase (一种P450脂肪酸脱羧酶的酶学、酶工程及组合生物合成研究), National Natural Science Foundation of China (面上项目,NSFC 31270855)


Representative Publications


1. Ye, Y.#, Du, L.#, Zhang, X.,Newmister, S. A.,McCauley, M.,Alegre-Requena, J. V., Zhang, W., Mu, S.,Minami, A.,Fraley, A. E.,Adrover-Castellano, M. L.,Carney, N. A., Shende, V. V., Qi, F.,Oikawa, H., Kato, H.,Tsukamoto, S., Paton, R. S.,Williams, R. M.*, Sherman, D. H.*, andLi, S.* Fungal-derived Brevianamide assembly by a stereoselective semi-pinacolase.Nat. Catal.(Accepted)

2.Li, S.*, Du, L., and Bernhardt, R.* Redox partners: Function modulators of bacterial P450 enzymes.Trends Microbiol.2020, doi.org/10.1016/j.tim.2020.02.012.

3. Jiang, Y., Li, Z., Zheng, S., Xu, H., Zhou, Y. J., Gao, Z., Meng, C. *, andLi, S.* Establishing an enzyme cascade for one-pot production of α-olefns from low-cost triglycerides and oils without exogenous H2O2addition.Biotechnol. Biofuels2020, 13, 52.

4. Yang, S., Cao, X., Yu, W.,Li, S., Zhou, Y. J. * Efficient targeted mutation of genomic essential genes in yeastSaccharomyces cerevisiae.Appl. Microbiol. Biotechnol.2020, 104(7):3037-3047.

5. Li, Z.#, Jiang, Y.#, Guengerich, F. P., Ma, L.,Li, S., and Zhang, W. * Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications.J. Biol. Chem.2020,295(3), 833-849.

6. Xu, H., Liang, W., Ning, L., Jiang, Y., Yang, W., Wang, C., Qi, F., Ma, L., Du, L., Fourage, L., Zhou, Y. J. andLi, S.* Directedevolution of P450fattyaciddecarboxylases viahigh-throughputscreening towardsimprovedcatalyticactivity.ChemCatChem2019, 12(1),80-84.

7. Jia, K., Zhu, L., Qu, X.,Li, S., Shen, Y., Qi, Q., Zhang, Y., Li, Y., and Tang, Y.* Enzymatic o‑glycosylation of etoposide aglycone by exploration of the substrate promiscuity for glycosyltransferases.ACS Synth. Biol.2019, 8(12), 2718-2725.

8. Duan, X.#, Ma, X.#,Li, S., and Zhou, Y.* Free fatty acids promote transformation eficiency of yeast.FEMS Yeast Res.2019, 19(7), foz069.

9. Liu, K., andLi, S.* Biosynthesis of fatty acid derived hydrocarbons: perspectives on enzymology and enzyme engineering,Curr.Opin.Biotechnol.2019, 62, 7-14.

10. Zhang, W., Du, L., Qu, Z., Zhang, X., Li, F., Li, Z., Qi, F., Wang, X., Jiang, Y., Men, P., Sun, J., Cao, S., Geng, C., Qi, F., Wan, X., Liu, C., andLi, S.* Compartmentalized Biosynthesis of Mycophenolic Acid.Proc. Natl. Acad. Sci. U.S.A.2019, 116(27),13305-13310.

11. Jiang, Y., Li, Z., Wang, C., Zhou, Y. J., Xu, H.*, andLi, S.*Biochemical characterization of three newα-olefn-producing P450 fatty acid decarboxylases with a halophilic property.Biotechnol. Biofuels2019, 12, 79.

12. Zhang, W.#, Du, L.#, Li, F., Zhang, X., Qu, Z., Han, L., Li, Z., Sun, J., Qi, F., Yao, Q., Sun, Y., Geng, C.,Li, S.* Mechanistic insights into interactions between bacterial class I P450 enzymes and redox partners.ACS Catal.2018, 8, 9992-10003.

13. Zhang, X.#, Li, P.#, Qin, G.,Li, S., Voogd, J. N., Tang, X.*, and Li, G.* Isolation and absolute configurations of diversiform C17, C21 and C25terpenoids from themarinespongeCacospongiasp.Mar. Drugs2018, 17(1), 14.

14. Huang, Y., Zheng, X., Pilgaard, B., Holck, J.,Muschiol, J.,Li, S., andLange, L.* Identification and characterization of GH11 xylanase and GH43 xylosidase from the chytridiomycetous fungus,Rhizophlyctis rosea.Appl. Microbiol. Biotechnol.2018, 103(2), 777-791.

15. Li, Q.*, Ding, W., Yao, Z., Tu, J., Wang, L., Huang, H.,Li, S., and Ju, J.* AbmV catalyzes tandem ether installation and hydroxylation during neoabyssomicin/abyssomicin biosynthesis.Org. Lett.2018, 20, 4854-4857.

16. Jiang, Y.,Li, S.* The catalytic function and application of cytochrome P450 enzymes in biosynthesis and organic synthesis.Chin. J.Org.Chem.2018,38(9), 2307-2323.

17. Qi, F.#, Lei, C.#, Li, F., Zhang, X., Wang, J., Zhang, W., Fan, Z., Li, W., Tang, G., Xiao, Y.*, Zhao, G.,Li, S.* Deciphering the late steps of rifamycin biosynthesis.Nat. Commun.2018, 9,2342.

18. Chen, H., Meng, X., Xu, X., Liu, W.,Li, S.*The molecular basis for lipase stereoselectivity.Appl. Microbiol. Biotechnol.2018,102(8),3487-3495.

19. Xu, H., Ning, L., Yang, W., Fang, B., Wang, C., Wang, Y., Xu, J., Colin, S., Laeuffer, F., Fourage, L., andLi, S.*In vitrooxidative decarboxylation of free fatty acids to terminal alkenes by two new P450 peroxygenases.Biotechnol. Biofuels2017, 10,208.

20. Zhang,W.#,Huffman, J.#,Li, S.,Shen, Y. *,and Du,L.,* Unusual acylation of chloramphenicol in Lysobacter enzymogenes, a biocontrol agent with intrinsic resistance to multiple antibiotics.BMCBiotechnol.2017, 17, 59.

21. Zhang, X., andLi, S.* Expansion of chemical space for natural products by uncommon P450 reactions.Nat. Prod. Rep.2017, 34(9), 1061-1089.

22. Du, L.#, Dong, S.#, Zhang, X., Jiang, C., Chen, J., Yao, L., Wang, X., Wan, X., Liu, X., Wang, X., Huang, S., Cui, Q., Feng, Y. *, Liu, S.*, andLi, S.* Selective oxidation of aliphatic C–H bonds in alkylphenols by a chemomimetic biocatalytic system.Proc. Natl. Acad. Sci. U.S.A.2017,114(26), E5129-E5137.

23. Li, Z., Du, L., Zhang, W., Zhang, X., Jiang, Y., Liu, K., Men, P., Xu, H., Fortman, J. L., Sherman, D. H., Yu, B., Gao, S.,Li,S.*Complete elucidation of the late steps of bafilomycin bios ynthesis inStreptomyces lohii.J. Biol. Chem.2017, 292(17), 7095-7104.

24. Yao, Q.#, Ma, Li.#, Liu, L., Ikeda, H., Fushinobu, S.,Li, S., and Xu, L.* Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) fromStreptomyces avermitilis.J. Microbiol. Biotechnol.2017, 27(5), 956–964.

25. Fang, B.#, Xu, H.#, Liu, Y., Qi, F., Zhang, W., Chen, H., Wang, C., Wang, Y., Yang, W., andLi, S.* Mutagenesis and redox partners analysis of the P450 fatty acid decarboxylase OleTJE.Sci. Rep.2017, 7, 44258.

26. Sun, Y.#, Ma, L.#, Han, D.#, Du, L., Qi, F., Zhang, W., Sun, J., Huang, S., Kim, E.-S.,* andLi, S.*In vitroreconstitution of the cyclosporine specific P450 hydroxylases using heterologous redox partner proteins.J. Ind. Microbiol. Biotechnol.2016, 44(2),161-166.

27. Zhang, X., Li, Z., Du, L., Chlipala, G. E., Lopez, P. C., Zhang, W., Sherman, D. H.*, andLi, S.*Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis.Tetrahedron Lett.2016, 57(52), 5919-5923.

28. Zheng, X., Fang, B., Han, D., Yang, W., Qi,F., Chen, H., andLi, S.*Improving the Secretory Expression of anα-Galactosidase fromAspergillus nigerinPichia pastoris.PLoS ONE2016,11(8), e0161529.

29. Du, L., Ma, L., Qi, F., Zheng, X., Jiang, C., Li, A., Wan, X., Liu, S.-J.*, andLi, S.*Characterization of a unique pathway for 4-cresol catabolism initiated by phosphorylation inCorynebacterium glutamicum.J. Biol. Chem.2016, 291(12), 6583-6594.

30. Ma, L., Du, L., Chen, H., Sun, Y., Huang, S., Zheng, X., Kim, E.-S.*, andLi, S.* Reconstitution of the in vitro activity of the cyclosporine-specific P450 hydroxylase fromSebekia benihanaand development of a heterologous whole cell biotransformation system.Appl. Environ. Microbiol.2015, 81(18), 6268-6275.

31. Woo, M. W., Lee, B. R., Nah, H.J., Choi, S. S.,Li, S., and Kim, E.-S.* Domain characterization of cyclosporin regio-specific hydroxylases in rare actinomycetes.J. Microbiol. Biotechnol.2015, 25(10), 1634-1639.

32. Qi, G.#*, Wang, D.#, Yu, L., Tang, X., Chai, G., He, G., Ma, W.,Li, S., Kong, Y., Fu, C. *, and Zhou, G.* Metabolic engineering of 2-phenylethanol pathway producing fragrance chemical and reducing lignin inArabidopsis.Plant Cell Rep.2015, 34(8), 1331-1342.

33. Bernard, S. M., Akey, D. L., Tripathi, A., Park, S. R., Konwerski, J. R., Anzai, Y.,Li, S., Kato, F., Sherman, D. H., and Smith, J. L.* Structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugarO-methyltransferases.ACS Chem. Biol.2015, 10(5), 1340-1351.

34. Yan, J.*, Liu, Y., Wang, C., Han, B., andLi, S.*Assembly of lipase and P450 fatty acid decarboxylase to constitute a novel biosynthetic pathway for production of 1-alkenes from renewable triacylglycerols and oils.Biotechnol. Biofuels2015, 8, 34.

35. Zhang, W., Cao, S., Qiu, L., Qi, F., Li, Z., Yang, Y., Huang, S., Bai, F., Liu, C., Wan, X.,* andLi, S.* Functional characterization of MpaG’, theO-methyltransferase involved in the biosynthesis of mycophenolic acid.Chembiochem2015, 16(4), 565-569.

36. Huang, S.*, Gao, J., Wu, R.,Li, S.and Bai Z.* Polydimethylsiloxane: A General Matrix for High-Performance Chromatographic NMR Spectroscopy.Angew. Chem. Intl. Ed.2014, 53, 11592-11595.

37. Zhang, W.#, Xu, L.#, Yang, L., Huang, Y.,Li, S., and Shen. Y.* Phomopsidone A, a novel depsidone metabolite from the mangrove endophytic fungusPhomopsis sp. A123.Fitoterapia2014, 96, 146-151.

38. Yan, J.*, Zheng, X., Du, L., andLi, S.*Integrated lipase production and in situ biodiesel synthesis in a recombinant Pichia pastoris yeast: an efficient dual biocatalytic system composed of cell free enzymes and whole cell catalysts.Biotechnol. Biofuels2014, 7, 55.

39. Wang, Q.#, Huang, X.#, Zhang, J., Lu, X.,Li, S., and Li, J.-J.*Engineering self-sufficient aldehyde deformylating oxygenase fused to alternative electron transfer systems for efficient conversion of aldehydes into alkanes.Chem. Comm.2014, 50(33), 4299-4301.

40. Zhang, W., Liu, Y., Yan, J., Cao, S., Bai, F., Yang, Y., Huang, S., Yao, L., Anzai, Y., Kato, F., Podust, L. M., Sherman, D. H.*, andLi, S.*New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners.J. Am. Chem. Soc. 2014, 136(9), 3640-3646. (Faculty of 1000 Prime: http://f1000.com/prime/718276150)

41. Liu, Y., Wang, C., Yan, J., Zhang, W., Guan, W., Lu, X., andLi, S.*Hydrogen peroxide-independent production ofα-alkenes by OleTJEP450 fatty acid decarboxylase.Biotechnol. Biofuels2014, 7, 28.

42. Yan, J.*, Zheng, X., andLi, S.*A novel and robust recombinantPichia pastorisyeast whole cell biocatalyst with intracellular overexpression of aThermomyces lanuginosuslipase: preparation, characterization and application in biodiesel production.Bioresour. Technol.2014, 151, 43-48.

43. Zhang W., Fortman, J. L., Carlson, J. C., Yan, J., Liu, Y., Bai, F., Guan, W., Jia, J., Matainaho, T., Sherman, D. H.*, andLi, S.* Characterization of the bafilomycin biosynthetic gene cluster fromStreptomyces lohii.Chembiochem, 2013, 14(3), 301-306.

44. Sunderhaus, J. D., McAfoos, T. J., Finefield, J. M., Kato, H.,Li, S., Tsukamoto, S., Sherman, D. H., and Williams, R. M.* Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin A and notoamide B.Org. Lett.2013, 15(1), 22-25.

45.Li, S., Tietz, D. R., Rutaganira, F. U., Kells, P. M., Anzai, Y., Kato, F., Pochapsky, T. C., Sherman, D. H., and Podust, L. M.* Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions.J. Biol. Chem.2012, 287(45), 37880-37890.

46. Anzai, Y. *, Tsukada, S. I., Sakai, A., Masuda, R., Harada, C., Domeki, A.,Li, S.,Kinoshita, K., Sherman, D. H., and Kato, F. Function of the cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicin.Antimicrob. Agents Chemother.2012, 56(7), 3648-3656.

47.Li, S., Anand, K., Tran, H., Yu, F., Finefield, J. M., Sunderhaus, J. D., McAfoos, T. J., Tsukamoto, S., Williams, R. M.*, and Sherman, D. H.*Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways.MedChemComm2012, 3(8), 987-996.

48.Li, S., Finefield, J. M., Sunderhaus, J. D., McAfoos, T. J., Williams, R. M.*, and Sherman, D. H.*Biochemicalcharacterization of NotB as an FAD-dependentoxidase in thebiosynthesis ofnotoamideindolealkaloids.J. Am. Chem. Soc.2012, 134(2), 788-791.

49. Akey, D. L.,Li, S., Konwerski, J., Confer, L., Bernard, S. M., Anzai, Y., Kato, F., Sherman, D. H., and Smith, J. A.* Newstructuralform in the SAM/metal-dependentO-methyltransferasefamily: MycE from themycinamycinbiosyntheticpathway.J. Mol. Biol.2011, 413(2), 438-450.

50. Carlson, J. C.#,Li, S.#, Gunatilleke, S. S., Anzai, Y., Burr, D. A., Podust, L. M., and Sherman, D. H.* Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes.Nat. Chem.2011, 3(8), 628-633.

51. Ding, Y., de Wet, J. R., Cavalcoli, J.,Li, S., Greshock, T. J., Miller, K. A., Finefield, J. M., Sunderhaus, J. D., McAfoos, T. J., Tsukamoto, S., Williams, R. M.*, and Sherman, D. H.* Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derivedAspergillussp.J. Am. Chem. Soc.2010, 132(36), 12733-12740.

52. McAfoos, T. J.,Li, S., Tsukamoto, S., Sherman, D. H., and Williams, R. M.* Studies on the Biosynthesis of the stephacidins and notoamides. Total synthesis of notoamides.Heterocycles2010, 82(1), 461-472.

53. Tsukada, S., Anzai, Y.,Li, S., Kinoshita, K., Sherman, D. H., and Kato, F.* Gene targeting for O-methyltransferase genes, mycE and mycF, on the chromosome ofMicromonospora griseorubidaproducing mycinamicin with a disruption cassette containing the bacteriophage φC31attB attachment site.FEMS Microbiol. Lett.2010, 304(2), 148-156.

54. Carlson, J. C., Fortman, J. L., Anzai, Y.,Li, S., Douglas, A. B., and Sherman, D. H.*Identification of the tirandamycin biosynthetic gene cluster fromStreptomycessp. 307-9.Chembiochem2010, 11(4), 564-572.

55.Li, S., Chaulagain, M. R., Knauff, A. R., Podust, L. M., Montgomery, J.*, and Sherman, D. H.* Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 monooxygenase.Proc. Natl. Acad. Sci. U.S.A.2009, 106(44), 18463-18468.

56. Carlson, J. C.#,Li, S.#, Douglas, A. B., and Sherman, D. H.*Isolation and characterization of tirandamycins from a marine-derivedStreptomycessp.J. Nat. Prod.2009, 72(11), 2076-2079.

57.Li, S.,Anzai, Y., Kinoshita, K., Kato, F., Sherman, D. H.* Functional analysis of MycE and MycF, twoO-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics.Chembiochem2009, 10(8), 1297-1301.

58.Li, S., Ouellet, H.,Sherman, D. H., Podust, L. M.* Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC fromStreptomyces venezuelae.J. Biol. Chem.2009, 284(9), 5723-5730.

59. Anzai, Y.#,Li, S.#,Chaulagain, M. R., Kinoshita, K., Kato, F., Montgomery, J., Sherman, D. H.*Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics.Chem. Biol.2008, 15(9), 950-959.

60.Li, S., Podust, L. M., Sherman, D. H.*Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain.J. Am. Chem. Soc.2007, 129(43), 12940-12941.

61.Li, S., Grüschow, S., Dordick, J. S., Sherman, D. H.*Molecular analysis of the role of tyrosine 224 in the active site ofStreptomyces coelicolorRppA, a bacterial type III polyketide synthase.J. Biol. Chem.2007, 282(17), 12765-12772.

62. Sherman, D. H.*,Li, S., Yermalitskaya, L. V., Kim, Y., Smith, J. A., Waterman, M. R., Podust, L. M*.The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC fromStreptomyces venezuelae.J. Biol. Chem.2006, 281(36), 26289-26297.

63.Li, S., Wang, J., Zheng, Z., Xu, Q., Huang, Y., Zhao, Y., Su, W.*1-(2,4-Dihydroxy-3,5-Dimethylphenyl)-ethanone (Clavatol).Acta. Cryst.2003, E59, o1649-o1650.


1. Dai, Z., Wang, Y., Zhou, Z.,Li, S., Zhang, X*.Synthetic Biology for Production of Plant-derived Natural Products.Bull. Chin. Acad. Sci.2018, 33(11), 1228-1238.

2. Zhong,.B., Du, L., Li, Z., Zhang, W., Zhang, X., Li, J., Huang, S., Hu, X.*,Li, S., Liu, K.* Biosynthesis of Gastrodin Based on the Cytochrome P450-Mediated Oxidative Biodegradation of 4-Cresol.J.HunanNormalUniv.(Natural Science)2018, 41(4), 33-40.

3. Sun, Y., Ma, L., Chen, H., Xu, H., Zheng, X., Qi, F.,Li, S.* Production of α-alkenes catalyzed by the fused lipase and P450fatty acid de-carboxylase.Chin.Sci.Bull.2017, 62(31), 3576-3582.

4. Sun, J., Liu, C., Li, R., Zhang, W. *,Li, S., Functional characterization of PbPT, a prenyltransferase fromPenicillium BrevicompactumNRRL 864.J. Qingdao Univ. (E&T), 2016, 31(2),107-115.

5. Li, Z., Zhang, W., andLi, S.* Cytochrome P450 enzymes and microbial drug development – A review.Acta Microbiol.Sin.2016, 56(3), 496-515.

6. Zhang, J., Zheng, Z.*, Huang, Y.,Li, S., Su, W. Preliminary research on antitumor activities of natural products from algal fungi.J. Xiamen Univ. (Natural Science)2004, 43 (4), 551-556.

7.Li, S., Zheng, Z.* Discovery and development of marine antitumor natural products.Mar. Sci. Bull.2003, 22(2), 76-82.


Honors and awards

1. Nov. 2019 ICBS-2019 Young Chemical Biologist Award

2. Aug. 2014The National Science Fund for Excellent Young Scholars (优青)

3. Sept. 2011Michigan Memorial Phoenix Energy Institute (MMPEI) Postdoctoral Fellowship

4. Apr. 2010National Award for Outstanding Chinese PhD Student Abroad 2009

5. Dec. 2005NR-BLAKE,MR. AND MRS. EDWARD Fellowship, College of Pharmacy, The University of Michigan



1. Chimeric Cytochrome P450 Proteins and Methods of Use.LI, Shengying, and SHERMAN, David H. (US 20090081758A1)

2. A Method for Selective Oxidation of C-H Bonds by an Engineered P450 Enzyme.LI, Shengying, SHERMAN, David H., CHAULAGAIN, Mani Raj, MONTGOMERY, John, and KNAUFF, Allison R. (WO 2011038313A2)

3. Biosynthetic Systems Producing Fungal Indole AlkaloidsLI, Shengying, David H. Sherman, Krithika Anand, and Robert M. Williams(AuthorizationNo.: US 9650656 B2)

4. 阎金勇,李盛英。一种利用偶联生产脂肪酶的方式催化生产生物柴油的方法(申请号:201410138507.3,申请公布号:CN103923954A)

5. 李盛英,刘奕,吕雪峰,刘旭峰。一种生产脂肪端烯的方法及其应用(申请号:201410660346.4)

6. 阎金勇,李盛英。一种基于脂肪酶与P450脂肪酸脱羧酶偶联催化的脂肪烯烃催化合成方法(申请号:201510003451.5,申请公布号:CN104561152A,授权号:ZL201510003451.5)

7. 李盛英,马莉,Eung-Soo Kim。一种制备毛发生长促进剂的生物转化方法(申请号:201510346350.8,申请公布号:CN106319007A,授权号:ZL201510346350.8)

8. 李盛英,杜磊,刘双江。一种酚类化合物催化氧化系统及其应用(申请号:201610015698.3)

9. 李盛英,郑贤良。高效分泌表达黑曲霉α-半乳糖苷酶AGA的工程菌及其构建和应用(申请号:2015107066150,申请公布号:CN105219791A)

10. 李盛英,房博,齐凤霞,张伟,杜磊。支撑P450脂肪酸脱羧酶活性的还原伴侣蛋白组合及其应用(申请号:201610151612.X,申请公布号:CN107201356A)

11. Production of Alpha-Olefins. Fourage Laurent, Laeuffer Frederie, Strub Henri, Wang Yun, Xu Jian, Xu Huifang, Li Shengying.( AuthorizationNo.: US 10407638B2)

12. Method for detecting hydrogen peroxide conversion activity of an enzyme. Li Shengying, Xu Huifang, Ning Linlin.( EP17290115.9)

13. Improved cytochrome P450 fatty acid decarboxylases. Li Shengying, Xu Huifang, Ning Linlin.( EP18290089.4)

14. 李盛英,李众,杜磊,张兴旺,张伟。一种巴弗洛霉素高产工程菌及其构建和应用(申请号:201811634377.7)

15. 李盛英,李众。一类四环二萜类化合物及其制备方法与应用(申请号:201911072144.7)

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