Education
Degree |
Date |
Affiliation |
Major |
PhD |
2004-06-20 |
Shandong University |
Microbiology |
Master |
1999-05-01 |
Shandong University |
Microbiology |
Bachelor |
1982-07-01 |
Fudan University |
Microbiology |
Research Experience
Date |
Affiliation |
Position |
1992-present |
Microbial Technology Institution , Shandong University |
Professor |
1982-1992 |
JiangSu Institute of Microbiology |
Assistant Professor |
Research Interests
Prof. Xu directs research programs focusing on understanding and linking genetic traits with phenotypic behavior of antimicrobial resistant bacteria, especially his laboratory is interested in identifying the prevalence, occurrence, and sources of antimicrobial resistant genes/microorganisms that occur within the aquatic system and are of consequence to human therapeutic treatment. He aims to better identify reservoirs of and mechanisms of horizontal transferring of antibiotic resistance genes and the functions of those genes from environmental bacteria.
Research Projects
1. The National Natural Science Foundation of China (31881230740)”China-UK AMR Partnership Hubs 2018 Panel meeting”, 2018.10-2018.12.
2. The National Natural Science Foundation of China (31781220657)”China-New Zealand Workshop on Noncommunicable Diseases“, 2017.12-2017.12.
3. The National Natural Science Foundation of China (31770042)”The regulatory mechanism on the expression of antibiotic resistance genes in Class 1 integrons by the cAMP-CRP pathway in Escherichia coli”, 2018.01-2021.12.
4. The National Science and Technology Major Project (2013ZX10004217-003) “Analysis of drug resistance genes and their transfer from super resistant bacteria in the broiler industry chain”, 2013.01-2015.12.
5. The National Natural Science Foundation of China (31170112)”Study on Dissemination of Plasmid-Mediated Quinolone Resistance Genes in Environmental Wastewaters and Genetic Structures of Relevant Drugs-Resistant Enterobacteriaceae”, 2012.01-2015.12.
6. The National Natural Science Foundation of China (30870084)”Isolation of antibiotic resistance bacteria and characterization integrons in aquatic environments”, 2009.01-2011.12.
7. The National Natural Science Foundation of China (30470018)”Molecular and Genetic Characterization of Novel Synthetic Pathway of Isoleucine in Leptospira Interrogans”, 2005.01-2007.12.
Representative Publications
1) Li L, Yu T, Ma Y, Yang Z, Wang W, Song X, Shen Y, Guo T, Kong J, Wang M *,Xu H*. 2019. The genetic structures of an Extensively Drug Resistant (XDR)Klebsiella pneumoniaeand its plasmids. Front Cell Infect Microbiol 8:446.
2) Wang M #, Ma Y #, Li L, Wang B, Wei X, Zhang M, Wang J, Cui Q, Li Z *,Xu H*. 2019. The diversity of glycosylation of cellobiohydrolase I fromTrichoderma reesei determined with mass spectrometry. Biochem Biophys Res Commun 508(3):818-824.
3) Bie L, Fang M, Li Z, Wang M *,Xu H*. 2018. Identification and characterization of new resistance-conferring SGI1s (Salmonellagenomic island 1) inProteus mirabilis. Front Microbiol 9:3172.
4) Wang M #, Shen W #, Yan L, Wang X,Xu H*. 2017. Stepwise impact of urban wastewater treatment on bacterial community structure, content of antibiotics, and prevalence of antimicrobial resistance. Environ Pollut 231(P2):1578-1585.
5) Yuan S, Gao M, Zhu F, Afzal MZ, Wang Y,Xu H, Wang M, Wang S, Wang X*. 2017. Disintegration of aerobic granules during prolonged operation. Environ Sci: Water Res Technol 3:757.
6) Guo N, Wang Y*, Yan L, Wang X, Wang M,Xu H, Wang S*. 2017. Effect of bioelectrochemical system on the fate and proliferation of antibiotic resistance genes during the treatment of chloramphenicol wastewater. Water Res 117:95-101.
7) Yan L, Liu D, Wang X, Wang Y, Wang M*,Xu H*. 2017. Bacterial plasmid-mediated quinolone resistance genes in aquatic environments in China. Sci Rep 7:40610.
8) Hao, Wu., Mingyu Wang, Yuqing Liu,Xinhua Wang,Yunkun Wang, Jinxing Lu, Hai Xu*. 2016.Characterization of antimicrobial resistance in Klebsiella species isolated from chicken broilers.Int. J. Food Microbiol.232: 95-102.
9) Hao, Wu., Shibo, Xia., Fanyun, Bu., Jing, Qi., Yuqing, Liu.,Hai, Xu*. 2015. Identification of integrons and phylogenetic groups of drug-resistant Escherichia coli from broiler carcasses in China. Int. J. Food Microbiol. 211: 51–56.
10) Xia, R., Y. Ren, X. H. Guo andH. Xu*. 2013. Molecular diversity of class 2 integrons in antibiotic-resistant gram-negative bacteria found in wastewater environments in China. Ecotoxicology. 22: 402-414.
11) Xia, R., Y. Ren andH. Xu*. 2013. Identification of Plasmid-Mediated Quinolone Resistance qnr Genes in Multidrug-Resistant Gram-Negative Bacteria from Hospital Wastewaters and Receiving Waters in the Jinan Area, China. Microb Drug Resist. 19: 446-456.
12) Liu, G., L. Zhang, Y. Qin, G. Zou, Z. Li, X. Yan, X. Wei, M. Chen, L. Chen, K. Zheng, J. Zhang, L. Ma, J. Li, R. Liu,H. Xu, X. Bao, X. Fang, L. Wang, Y. Zhong, W. Liu, H. Zheng, S. Wang, C. Wang, L. Xun, G. P. Zhao, T. Wang, Z. Zhou and Y. Qu. 2013. Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes. Sci Rep. 3:1569.
13) Kevin J. Allen*, Chad R. Laing, Ana Cancarevic, Yongxiang Zhang, Lili R. Mesak,Hai Xu, Ana Paccagnella, Victor P. J. Gannon, and Linda Hoang . 2013. Characteristics of Clinical Shiga Toxin-Producing Escherichia coli Isolated from British Columbia. BioMed Research International 2013: 1-11.
14) Ning, H., D. H. Sheng andH. Xu*. 2012. Role of Escherichia coli strain subgroups, integrons, and integron-associated gene cassettes in dissemination of antimicrobial resistance in aquatic environments of Jinan, China. Water Sci Technol. 66: 2385-2392.
15) Guo ¹, X. H., R. Xia ¹, N. Han andH. Xu*. 2011. Genetic diversity analyses of class 1 integrons and their associated antimicrobial resistance genes in Enterobacteriaceae strains recovered from aquatic habitats in China. Lett Appl Microbiol. 52: 667–675.
16) Xu, H*., K. Broersma, V. Miao and J. Davies. 2011. Class 1 and Class 2 integrons in multidrug resistant Gram-negative bacteria isolated from the Salmon River, British Columbia. Can J Microbiol. 57: 460-467.
17) Xu*, H., V. Miao, W. Kwong, R. Xia and J. Davies. 2011. Identification of a Novel Fosfomycin Resistance Gene (fosA2) in Enterobacter cloacae from the Salmon River, Canada. Lett Appl Microbiol. 52: 427–429
18) Xia R, Guo XH, Zhang YZ,Xu* H. qnrVC-Like Gene Located in a Novel Complex Class 1 Integron Harboring the ISCR1 Element in an Aeromonas punctata Strain from an Aquatic Environment in Shandong Province, China. Antimicrob Agents Chemother. 2010; 54(8): 3471-3474.
19) Xu, H., J. Davies and M. Vivian*. 2007. Molecular Characterization of Class 3 Integrons from Delftia spp. J Bacteriol. 189: 6276-6283.
20) Zhang, P., J. Ma, Z. L. Zhang, M. W. Zha,H. Xu, G. P. Zhao and J. P. Ding. 2009. Molecular basis of the inhibitor selectivity and insights into the feedback inhibitionmechanism of citramalate synthase from Leptospira interrogans. Biochem J. 421:133-143.
21) Ma, J. P., Zhang, Z. L. Zhang, M. W. Zha, H. Xu, G. P. Zhao and J. P. Ding. 2008. Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans. Biochem J. 415: 45–56.
22) Zou, Y., X. Guo, M. Picardeau,H. Xu and G. P. Zhao. 2007. A comprehensive survey on isoleucine biosynthesis pathways in seven epidemic Leptospira interrogans reference strains of China. FEMS Microbiol Lett. 269: 90-96. .
23) Xu, H., Y. Z. Zhang, X. K. Guo, S. X. Ren, A. A. Staempfli, J. S. Chiao, W. H. Jiang, G. P. Zhao. 2004. Isoleucine biosynthesis in Leptospira interrogans serotype lai strain #56601 proceeds via a threonine-independent pathway J Bacteriol. 183: 5400-5409.
24) Ren, S. X., G. Fu, X. G. Jiang, R. Zeng, Y. G. Miao,H. Xu, Y. X. Zheng, H. Xiong, G. Lu, L. F. Lu, et al. 2003. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 422: 888-893.
25) Wu, H., M.Y. Wang, Y.Q. Liu, X.H. Wang, Y.K. Wang, J.X. Lu,H. Xu*. 2016. Data on the phylogenetic typing, integron gene cassette array analysis, multi-drug resistance analysis and correlation between antimicrobial resistance determinants inKlebsiellastrains. Data in Brief.8: 1289-1294.
Honors and awards
1. Shandong Province Higher invention Excellence Award (1995)
2. State Board of Education Science and Technology progress Award, first class (1997)
3. National Invention Award, fourth class (1998)
Patents
1. Xu, H., X. H. Guo, R. R. Xia. 2013. Method of detection of bacterial integron arrays using EcoRII enzyme, patent number:01110080541.6; 2013.09.18
