Education
Degree |
Date |
Affiliation |
Major |
PhD |
1997-2000 |
Central China Agricultural University, China |
Biochemistry and Molecular Biology |
Master |
1994-1997 |
Shandong University, China |
Microbiology |
Bachelor |
1990-1994 |
Shandong University, China |
Microbiological Engineering |
Research Experience
Date |
Affiliation |
Position |
2014-Present |
Shandong University, China |
Associate Professor, Professor |
2006-2014 |
Central China Normal University, China |
Associate Professor |
2003-2005 |
The University of Tokyo, Japan |
Postdoctoral Researcher, JSPS foreign Researcher |
2001-2003 |
Max-Planck Institute for Chemical Ecology, Germany |
DAAD Postdoctoral Researcher |
Research Interests
Mining and biosynthesis of microbial secondary metabolites: Screening bioactive natural products (NPs) from microorganisms; Identifying genes involved in the regulation and biosynthesis of NPs
Research Projects
National Natural Science Foundation of China (32270088)
National Key Research and Development Program of China (2019YFA0905700)
National Key Research and Development Program of China (2018YFA0900400)
National Natural Science Foundation of China (31170050)
National Natural Science Foundation of China (30770036)
Representative Publications
1. Yiming Zhao, Boopathi Seenivasan, Ruijuan Li, Caiyun Li, Youming Zhang*, Vinothkannan Ravichandran*, Lin Zhong*, Aiying Li*. Exploring daidzein dimethyl ether from Albizzia lebbeck as a novel quorum sensing inhibitor against Pseudomonas aeruginosa: Insights from in vitro and in vivo studies. Bioorganic Chemistry. 2025;156(2025):108168.
2. Khorshed Alam , Md. Sawkat Hossain , Yiming Zhao , Zhiheng Zhang , Shouying Xu ,Jinfang Hao , Qing Yang , Aiying Li*. Tryptanthrins as multi-bioactive agents: discovery, diversity distribution and synthesis. Bioorganic Chemistry. 2025:154(2025):108071
3. Khorshed Alam, Jinfang Hao, Lin Zhong, Guoqing Fan, Qing Ouyang, Md Mahmudul Islam, Saiful Islam, Hongluan Sun, Youming Zhang*, Ruijuan Li*, Aiying Li*. Complete genome sequencing and in-silico genome mining reveals the promising metabolic potential in streptomyces species in CS-7. Frontiers in Microbiology. 2022;13:939919
4. Khorshed Alam, Jinfang Hao, Youming Zhang*, Aiying Li*. Synthetic biology-inspired Strategies and tools for engineering of microbial natural product biosynthetic pathways. Biotechnology Advances. 2021;49 (2021) :107759
5. Xiaofeng Cai, Takaaki Taguchi, Huili Wang, Megumi Yuki, Megumi Tanaka, Kai Gong, Jinghua Xu, Yiming Zhao, Koji Ichinose* and Aiying Li*. Identification of a C-glycosyltransferase involved in medermycin biosynthesis. ACS Chemical Biology. 2021;16(6):1059-1069
6. Xiaofeng Cai, Caiyun Li, Koji Ichinose, Yali Jiang, Ming Liu, Huili Wang, Caixia Gong, Le Li, Juan Wan, Yiming Zhao, Qing Yang, Aiying Li*. A single-domain small protein Med-ORF10 regulates the production of antitumor agent medermycin in Streptomyces. Microbial Biotechnology. 2021; 14(5):1918-1930
7. Muhammad Nazeer Abbasi, Jun Fu, Xiaoying Bian, Hailong Wang*, Youming Zhang*, Aiying Li*. Recombineering for genetic engineering of natural product biosynthetic pathways. Trends in Biotechnology. 2020;38(7): 715-728
8. Lin Zhong, Vinothakannan Ravichandran, Na Zhang, Hailong Wang, Xiaoying Bian *, Youming Zhang *, Aiying Li *. Attenuation of Pseudomonas aeruginosa quorum sensing by natural products: Virtual screening, evaluation and biomolecular interactions. International Journal of Molecular Sciences. 2020;21(6):2190
Honors and awards
1. 2019, Natural Science Award, by Ministry of Education, China, Grade: second prize; Certificate No: 2019-100-R05
Patents
1. Aiying Li, Xiaofeng Cai, Ming Liu, Ruijuan Li, Caiyun Li, Youming Zhang. A Novel Streptomyces-Derived Regulatory Factor and the Construction and Application of Its Native and Heterologous Expression Engineered Strains. Patent No.: ZL2020110178561, Grant Date: November 9, 2023
2. Aiying Li, Jin Lyu, Jinghua Xu, Youming Zhang, Ruijuan Li, Caiyun Li. A Heterologous Expression Engineered Strain of an Extremophilic Alkaline Protease and Its Application. Patent No.: ZL201711459372.0; Grant Date: February 19, 2021
3. Aiying Li, Juan Wan, Huili Wang. A Genetically Engineered Strain for Enhancing Medermycin Biosynthesis and Its Application. Patent No.: ZL201210120018.6, Grant Date: April 16, 2014
4. Aiying Li, Huili Wang, Xiaofeng Cai. Construction and Application of a Multi-Gene Co-Expression System for Angolosamine Glycosyltransferase and Glycosyl Synthetase. Patent No.: ZL200910063347.X, Grant Date: May 11, 2011
5. Aiying Li, Jinfang Hao, Ruijuan Li, Yiming Zhao, Caiyun Li. A Sesquiterpene Synthase-Encoding Gene Derived from Streptomyces, Genetically Engineered Strain and Applications Thereof. Application No.: 2023111099838, Filing Date: August 30, 2023
6. Aiying Li, Caiyun Li, Jinghua Xu, Huanyun Zhang, Ruijuan Li, Jinfang Hao, Youming Zhang. Regulatory Factor Derived from Streptomyces, Regulatory Factor Interaction System, Genetically Engineered Strain and Applications Thereof. Application No.: 2024117811676, Filing Date: December 5, 2024
