Education
Degree |
Date |
Affiliation |
Major |
PhD |
2016.06 |
Shanghai institute of Organic Chemistry, Chinese Academy of Sciences |
Organic chemistry |
Bachelor |
2011.06 |
Shandong University |
Chemistry |
Research Experience
Date |
Affiliation |
Position |
2019.02-Now |
Shandong University |
Assistant professor |
2018.06-2019.02 |
Shandong University |
Assistant professor |
2017.06-2018.05 |
Zhejiang Universityof Technology |
Assistant professor |
2016.07-2017.05 |
Shanghai institute of Organic Chemistry, Chinese Academy of Sciences |
Assistant professor |
Research Interests
Mainly focus on the natural products biosynthesis. Compounds with unique chemical structures or vital physiological activities are chosen to analyze the biosynthetic pathways and uncover novel enzymatic mechanisms.
Research Projects
1. 2020.01-2022.12, The biosynthesis and enzymatic mechanism of polyyne natural products from bacteria. Youth Program of National Natural Science Foundation of China (Grant No. 21907057). Host
2. 2019.07-2022.06, The biosynthetic mechanism of cepacins.Youth Program of Natural Science Foundation ofJiangsu Province (Grant No. BK20190201). Host
3. 2019.03-2021.12, The biosynthesis and enzymatic mechanism of polyyne natural products from bacteria.The Fundamental Research Funds of Shandong University (Grant No. 2019GN032). Host
Representative Publications
1.Guannan Zhong, Hua Chen,Wen Liu, Recent advances in the biosynthesis of lincosamide antibiotics.Chinese Science Bulletin, 2019, 64, 13-27.
2.Guannan Zhong, Hua Chen, Wen Liu. Reply to ‘C-C bond cleavage in biosynthesis of 4-alkyl-L-proline precursors of lincomycin and anthramycin cannot precede C-methylation’.Nature Communications, 2018, 9, 3168.
3.Guannan Zhong, Qunfei Zhao, Qinglin Zhang, Wen Liu. 4-Alkyl-L-(dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage.Nature Communications, 2017, 8, 16109.
4.Guannan Zhong, Ming Chen,Wen Liu. Structural diversity research of natural products based on biosynthetic mechanism.SCIENTIA SINICA Vitae, 2017, 47, 482-495
