Xin Song

Release date:2019-07-02    Author:     Editor: liyuan    Click:








School of Life Science, Shandong University




School of Life Science, Shandong University

Botany Virology



School of Life Science, Shandong University


Research Experience





Scientific and Developing Center nce and Technology exchange center



Department of Biological Engineering,Inha University



State key lab of Mirobial Technology,Shandong University

Associate professor


Research Interests

Microbial enzymology; Metabolic engineering and synthetic biology; Genomics, transcriptomics and proteomics; Fermentation engineering

Research Projects

(1) Applications of bioactivity of Sophorolipids in anti-biofilms in medical intubation 2018-2020

(2) National Natural Science foundation of China, Genomics used as tools for the investigation for sophorolipid synthesis enzymes and regulation mechanism No.31270089. 2013-2016

(3) Analysis and identification ofmicrobial biosurfactants 201401-201412

(4) Research on Endogenous Microbial OilExtractionTechnology Based on Functional Activator 2014-2015

(5) National Key Technology R&D Program in the 11th Five year Plan of china 2008BAI63B08,key technique of fermentation,separation and refinery of of saccharides 2008.01-2010.12, PI of subsubject

(6) National Key Technology R&D Program in the 12th Five year Plan of china, 2011BAC02B04,High-valued applications and clean production technique demonstration ofHelianthus tuberosus, 2012.01-2014.12, PI of subsubject

(7) National Natural Science foundation of China, Synthesis regulation and mechanism involved in sophorolipid synthesis ofWickerhamiella domercqiae var. sophorolipidsNo.30970052,2010-2012

(8) National Natural Science foundation of China, Enzyamatic modification of sophorolipid, construction ofmetabolism engineering microorganism and studies of bioactivity. PI,No. 30870048, 2009-2011

(9) Key project of Scientific and Technological of Shandong Province,Optimaization of fermentation process and studies of inhibition of microorganisms by sophorolipids (PI), 2007, No.,2007GG10002002

(10) National 863 Plan foundation, Studies of high active degrading enzymes for cellulose materials (Co-PI), 2007

(11) Foundation for excellent young scientist of Shandong Province,Optimaization of fermentation process and application of sophorolipid-producingWickerhamiella domercqiae (PI), 2006,No. 2006BS02010

(12) National Natural Science Foundation, Inhibition Mechanism of Yellowing of High Yield Pulps by biological methods, (Co-PI), 2006,No.30400338

(13) National 863 Plan foundation, Green New Biotechnology for Paper Making (Co-PI), 2004

(14) Doctoral Post Foundation of Ministry of Education, Construction of engineeringBeauveriaandapplication of high efficient and stable insecticide (Co-PI), 2004

(15) Foundation of Ministry of Education, Melanin decoration by enzymatic methods (PI), 2004

(16) Natural Science Foundation of Shandong Province, Biodiesel production from plant oil by enzymatic method (PI), 2003,No. 032040107

(17) Foundation for excellent young scientist of Shandong Province, Production and application of new sophorolipids (PI), 2002

(18) Natural Science Foundation of Shandong Province, Studies on new-type lipases (PI), 1997

Representative Publications

1 Chen Jing, Song Xin*, Qu Yin-bo, Screening of strains producing new sophorolipids and determination of their stucture. Enzyme and Microbial Technology, 2006, 39: 501~506(IF 2.287)

2 Xianyun Sun, Ziyong Liu, Kai Zheng,Xin Song*, Yinbo Qu, The composition of basal and induced cellulase systems inPenicillium decumbensunder induction or repression conditions,Enzyme and Microbial Technology,June 2008, 42(7): 560~567 (IF 2.287) (cited: 70)

3 Yuqi Qin, Xiaomin Wei,Xin Song*, Yinbo Qu*, Engineering endoglucanase II fromTrichoderma reeseito improve the catalytic efficiency at a higher pH optimum,Journal of Biotechnology, June 2008, 135:190-195(IF 3.045)cited: 80)

4 Yuqi Qin, Xiaomin Wei, Xin Song; Yinbo Qu, The role of the site 342 in catalytic efficiency and pH optima of endoglucanase II fromTrichoderma reesei as probed by saturation mutagenesis, Biocatalysis and Biotransformation, 2008, 26(5): 378 – 382 (SCI, IF 1.475)

5 Yan LIU, Peng YU,Xin SONG*, Yinbo QU,Hydrogen production from cellulose by co-culture ofClostridium thermocellum JN4andThermoanaerobacterium thermosaccharolyticum GD17, International Journal of hydrogen energy, June 2008, 33: 2927-2933(IF 4.054)(cited: 103)

6 Xin Song*, Xiaoyu Qi, Bin Hao, Yinbo Qu,Studies of Substrate Specificities of Lipases From Different Sources, Europe Journal of Lipid Science and Technology, 2008, 110(12): 1095-1101(IF 1.487)(ctied: 20)

7 Xin Song*, Xiaoyu Qi, Yinbo Qu, Resolution of (R,S)-(±)-glycidyl butyratewith Immobilized Trichosporoncapitatum Y-11 Lipase in gelatin-containing microemulsion-based organogels,Colloids and Surfaces B: Biointerfaces, 15 Nov 2008, 67(1): 127–131(IF 3.456)(cited: 6)

8 Yanliang Lin, Xin Song*,1, Juan Fu Jianqiang Lin Yinbo QuMicrobial transformation of phytosterol in corn flour and soybean flour to 4-androstene-3,17-dione byFusarium moniliforme Sheld. Bioresource Technology, 19 Jan 2009, 100(5): 1864-1867 ( IF 4.980) (cited:16)

9 Yanliang Lin, Xin Song*, Juan Fu,Jianqiang Lin Yinbo Qu Microbial transformation of androst-4-ene-3, 17-dione by Bordetella sp. B4CGMCC 2229, J of Chemical Technol Biotechnol. Jan 2009, 84(5):789-793(IF 2.168)(cited: 13)

10 Yanfei Cheng, Xin Song*, Yuqi Qin, YinboQu*.Genome shuffling improves production of cellulase by Penicillium decumbens JU-A10. Journal of Applied Microbiology, Apr 2009, 107(6): 1837-46 (IF 2. 337)(cited: 81)

11 Yanliang Lin,Juan Fu,Xin Song*. Purification and Characterization of an extracellular cholesterol oxidasefrom aBordetella species, Process Biochem. June 2010, 45: 1563-1569 (IF 2.627)

12 Xiaojing Ma, Hui Li, Lingjian Shao, Jing Shen, X Song*, Effects of nitrogen sources on production and composition of sophorolipids by Wickerhamiella domercqiae var. sophorolipid CGMCC 1576. Appl. Microbiol. Biot. May 2011, 91: 1623-1632 (SCI, IF 3.425) (cited: 26)

13 Lingjian Shao, Xin Song*, Xiaojing Ma, Hui Li, Yinbo Qu*. Bioactivties of Sophorolipid with Different Structures against Human Esophageal Cancer Cells, J Surgical Research, 2012, 173: 286-291 (IF 2.198)

14 Xiaojing Ma, Lingjian Shao, Hui Li, Jing Shen, Xin Song*,Surface and biological activity of sophorolipid molecules produced by Wickerhamiella domercqiae var. sophorolipid CGMCC 1576, Colloids and Surfaces B: Biointerfaces, Mar 2012, 376: 165-172 (SCI, IF 3.902)(cited:15次)

15 Hui Li, Xiaojing Ma, Lingjian Shao, Jing Shen, Xin Song* Enhancement of Sophorolipid Production ofWickerhamiella domercqiae var. sophorolipid CGMCC 1576 by Low-Energy Ion Beam Implantation Appl. Biochem. Biotechnol. June 2012, 167(3): 510~523 (IF 1.606) (cited:10)

16 Yanliang Lin, Jinglei Liu, Yibo Hu,Xin Song*, Yueran Zhao*. An antioxidant exopolysaccharide devoid of pro-oxidant activity produced by the soil bacterium Bordetella sp. B4. Bioresource Technology. Nov 2012, 124: 245-251(IF 4.917) (cited: 6次)

17 Hui Li, Xiaojing Ma, Lingjian Shao, Jing Shen,Xin Song*, Production of sophorolipids with eicosapentaenoic acid and docosahexaenoic acid fromWickerhamiella domercqiae var. sophorolipid using fish oil as a hydrophobic carbon source. Biotechnol. Lett. 2013, 35: 901–908. (IF 1.683)(cited: 4)

18 Xiaojing Ma, Hui Li, Dongxue Wang,Xin Song*. Sophorolipid production from delignined corncob residue by Wickerhamiella domercqiae var. sophorolipid CGMCC 1576 and Cryptococcus curvatus ATCC 96219. Appl Microbiol Biotechnol, 2014, 98(1): 475-83 (IF 3.737 ) (cited: 4)

19 Xiaoyu Qi,Xin Song* and Youmin Sun.Enhanced Soil Washing of PCB by Sophorolipids from Transformer Oil Contaminated Soil. Applied Mechanics and Materials 2014(694) 450-454. (EI)

20 Yibo Hu; Guodong Liu; Zhonghai Li; Yuqi Qin; Yinbo Qu, Xin Song*. G protein-cAMP signaling pathway mediated by PGA3 plays different roles in regulating the expressions of amylases and cellulases in Penicillium decumbens. Fungal Genetics and Biology, 2013, 58-59 (62-70) (IF 3.737) (cited: 12)

21 Yibo, Hu, H, Xue, G, Liu, X, Song*, Y, Qu. Efficient production and evaluation of lignocellulolytic enzymes using a constitutive protein expression system in Penicillium oxalicum, J Ind Microbiol Biotechnol, 2015, 42(6): 877-887(IF 2.439)

22 Shuzhen Zhang, Wen He*, Xudong Zhang,*, Guihua Yang*, Jingyun Ma, Xuen Yang, Xin Song*, Fabricating Fe3O4/Fe/Biocarbon Fibers using Cellulose Nanocrystals for High-Rate Li-ion Battery Anode, Electrochimica Acta, 2015, 174: 1175–1184(IF 4.803)

23 Qiaohuan Cheng, Wen He,* Xudong Zhang,* Mei Li and Xin Song, Recent advances in composite membranes modified with inorganic nanoparticles for high performance lithium ion batteries, RSC Advances, Jan 1 2016, 6:10250-10265

24 Jiashan Li, Hui Li, Weiwei Li, Chengqiang Xia,Xin Song*,Identification,characterization of aflavin-containing monooxygenase MoA and its function in a specific sophorolipid molecules metabolism inStarmerella bombicola. Appl Microbiol Biotechnol, 2016, 100:1307-1318(IF 3.337)

25 Zhonghai Li, Guangshan Yao, Ruimei Wu, Liwei Gao, Qinbiao Kan, Meng Liu, Piao Yang, Guodong Liu, Yuqi Qin, Xin Song, Yaohua Zhong, Xu Fang, Yinbo Qu*.Synergistic and Dose-Controlled Regulation of Cellulase Gene Expression inPenicillium oxalicum, PLOS Genetics,DOI:10.1371/journal.pgen.1005509September 11, 2015

26 Jiashan Li, Chengqiang Xia, Xiaoran Fang, Haizhao Xue, Xin Song*, Identification and characterization of a long-chain fatty acid transporter in the sophorolipid-producing strain Starmerellabombicola, Appl Microbiol Biotechnol (2016) 100: 7137-7150. DOI 10.1007/s00253-016-7580-y(IF 3.337)

27 Weiwei Li, Jiashan Li, Xin Song*, Utilization, the expression and function of cytochrome P450 in sophorolipid synthesis in Starmerella bombicola CGMCC 1576, Research & Reviews: Journal of Microbiology and Biotechnology, 2016, 5(2): 58-63

28 Haizhao Xue,Yibo Hu1, Xiaoran Fang1,Xin Song*, High efficiency and stable RNA interference vector construction forPenicillium sp., Research & Reviews: Journal of Microbiology and Biotechnology, 2016, 5(2): 76-83

29 Jiashan Li, Chengqiang Xia, Piao Yang, Xin Song*, Enhancement of sophorolipids yields by overexpressing the sophorolipids synthesis gene cluster in Starmerella bombicola,New Biotechnology , 2016, 33: 108, doi: 10.1016/j.nbt.2016.06.1098

30 Liwei Gao, Zhonghai Li*, Chengqiang Xia, Meng Liu, Piao Yang, Lele Yu, Yinbo Qu, Xin Song*, Combining manipulation of transcription factors and overexpression of the target genes to enhance lignocellulolytic enzyme production inPenicillium oxalicum, Biotechnology for Biofeul, 2017, 10(1) :100, doi:10.1186/s13068-017-0783-3(IF 6.08)

31 Hui Li, Wei Guo, Xiao-jing Ma, Jia-shan Li, Xin Song, In Vitro and in Vivo Anticancer Activity of Sophorolipids to Human Cervical Cancer, Appl Biochem Biotechnol, (2017) 181:1372–1387, DOI 10.1007/s12010-016-2290-6

32 Liwei Gao, Chengqiang Xia, Jiadi Xu, Zhonghai Li, Lele Yu, Guodong Liu*, Xin Song*, Yinbo Qu, Constitutive expression of chimeric transcription factors confers cellulose-independent cellulase synthesis inPenicillium oxalicum, Biotechnology Journal, 2017, 12:11 DOI: 10.1002/biot.201700119 (IF 3.781)(2017-09-18)

33 Xiaoyu Qi, Xiaoming Xu, Chuanqing Zhong, Tianyi Jiang, Wei Wei, Xin Song*Removal of Cadmium and Lead from Contaminated Soils Using Sophorolipids from Fermentation Culture ofStarmerellabombicola CGMCC 1576 Fermentation. International Journal of Environmental Research and PublicHealth 2018, 15, 2334 doi: 10.3390/ijerph15112334

34 Chengqiang Xia, Zhonghai Li, Yanning Xu,Piao Yang, Liwei Gao, Guodong Liu, Qin Yan, Shiying Li, Yanan Wang,Yinbo Qu, Xin Song*, Introduction of heterologous transcription factors and their target genes into Penicillium oxalicum leads to increased lignocellulolytic enzyme production,Appl Microbiol Biotechnol. 2019,doi.org/10.1007/s00253-018-09612-y

35 Liwei Gao, Shiying Li, Yanning Xu, Chengqiang Xia, Jiadi Xu, Jun Liu, Yuqi Qin, Xin Song*, Guodong Liu*, Yinbo Qu,Mutation of a conserved alanine residue in transcription factor AraR leads to hyper-production ofa-L-arabinofuranosidases in Penicillium oxalicum, Biotechnology Journal , 2019, DOI: 10.1002/biot.201800643 (IF 3.781)


Editor-in-Chief, Biotransformation by Microbial Enzymes, Chemical Industry Press, Beijing, June, 2004

Main Editor, Biotransformation in organic Chemistry, Chemical Industry Press, Beijing:Jan., 2006

Main Editor,English-Chinese Dictionary, Science Press, Beijing: Jan 2009

Honors and awards

Tianda Scholarship for excellent graduate students, 1999

Guanghua Scholarship for excellent graduate students, 1998

Production and applications of new sophorolipids,Shandong Science and Technology Award (Technology and Invention Award) The third prize(First Researcher)


Issued patents (14)

ZL 200610042190.9; ZL 200710114218.x; ZL 200710114837.9; ZL 200710114796.3

ZL 200810014833.8;ZL 200910230625.6; ZL 200610042181.x; ZL 201110403823.5;

ZL 201310500652.7; ZL201310239943.5; ZL201310239674.2; ZL201310239416.4;

ZL201410222903.4; ZL201310239942.0

Adress:State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China

Tel: (86)-0532-58631501  (86)-0532-58631597  Post Code: 266237

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