Education
Degree |
Date |
Affiliation |
Major |
PhD |
1983. - 1986. |
Shandong University |
Microbiology |
Master |
1978.– 1981. |
Shandong University |
Microbiology |
Bachelor |
|
|
|
Research Experience
Date |
Affiliation |
Position |
1974.8.– 1978.8. |
Jining distillery, Shandong |
Technician |
1981.10.– 1982.9. |
Osaka University/University of Tokyo |
Postgraduate |
1981.9. - 1988.8. |
Shandong University |
Assistant, Lecturer |
1988.8. - Now |
Shandong University |
Associate Professor/Professor |
1993.12. - 1994.4. |
Lund University, Sweden |
Visiting scholar |
1998.10.– 1999.9. |
Kyoto University, Japon |
Visiting scholar |
Research Interests
Fungalphysiology, enzymatic biochemistry and molecular microbiology.
Biodegradation and bioconversion of lignocellulosic biomass resources by microorganisms.
Cellulases and cellulosic ethanol production, and biorefinery of lignocellulosics.
Research Projects
As the Chief Scientist, his research on fundamentals underlying bioconversion of lignocellulosic biomass was granted by the National Basic Research Program (973 Program, 2011CB707400, 2011-2015).
Representative Publications
1. Purification and characterization of a novel cellobiohydrolase (PdCel6A) fromPenicillium decumbensJU-A10 for bioethanol production,Bioresource Technology, 2011, 102: 8339-8342.
2. N-Glycoform Diversity of Cellobiohydrolase I fromPenicillium decumbens and Synergism of Nonhydrolytic Glycoform in Cellulose Degradation, 2012,J Biol Chem, 287（19)；15906–15915.
3. Genomic and Secretomic Analyses Reveal Unique Features of the Lignocellulolytic Enzyme System ofPenicillium decumbens. 2013,PLoS ONE 8(2): e55185.
4. Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes.Scientific Reports, 2013,3: 1569 | DOI: 10.1038/srep01569.
5. Development of highly efficient, low-cost lignocellulolytic enzyme systems in thepost-genomic era,Biotechnology Advances, 2013, 31 (6)962-975.
6. Promotion of extracellular lignocellulolytic enzymes production by restraining the intracellularβ-glucosidase inPenicillium decumbens,Bioresource Technology, 2013,137 (2013) 33-40
7. Cellodextrin transporters play important roles in cellulase induction in the cellulolytic fungusPenicillium oxalicum.Appl Microbiol Biotechnol. 2013 Dec; 97(24):10479-88.
8. Functional characterization of protein kinase CK2 regulatory subunit regulating Penicillium oxalicum asexual development and hydrolyticenzyme production,Fungal Genetics and Biology, 2014, 66: 44-53.
9. Redesigning the regulatory pathway to enhance cellulase production in Penicillium oxalicum. Biotechnol Biofuels, 2015, 8:71.
10. Synergistic and Dose-controlled Regulation of Cellulase Gene Expression in Penicillium oxalicum.PLoS Genet, 2015. DOI: 10.1371/journal.pgen.1005509.
11. Penicillium oxalicum PoFlbC regulates fungal asexual development and is important for cellulase gene expression.Fungal Genet Biol. 2015 Dec 23; 86: 91-102.
12. Proteomic analysis of the biomass hydrolytic potentials ofPenicillium oxalicum lignocellulolytic enzyme system.Biotechnol Biofuels, 2016, 9: 68.
13. Expression and chromatin structures of cellulolytic enzyme gene regulated by heterochromatin protein 1，Biotechnol Biofuels, 2016, 9:206.
14. Production of a high-efficiency cellulase complex via β-glucosidase engineering in Penicillium oxalicum. Biotechnol Biofuels,2016,9:78.
15. Putative methyltransferase LaeA and transcription factor CreA are necessary for proper asexual development and controlling secondary metabolic gene cluster expression.Fungal Genet Biol. 2016, 94: 32-46.
16. The Different Roles ofPenicillium oxalicum LaeA in the Production of Extracellular Cellulase and β-xylosidase，Frontiers in Microbiology, 2016, 7: 2091.
17. Improving cellulase productivity ofPenicillium oxalicum RE-10 by repeated fed-batch fermentation strategy，Bioresource Technology 227 (2017) 155-163.
18. Identifying and overcoming the effect of mass transfer limitation on decreased yield in enzymatic hydrolysis of lignocellulose at high solid concentrations，Bioresource Technology 229 (2017): 88–95.
19. An aldonolactonase AltA fromPenicillium oxalicum mitigates the inhibition ofβ-glucosidase during lignocellulose biodegradation,Appl Microbiol Biotechnol, 2017, 101: 3627-3636.
20. Improvement of cellulolytic enzyme production and performance by rational designing expression regulatory network and enzyme system composition, Bioresource Technology 245 (2017) 1718-1726.
21. Continuous feeding of spent ammonium sulphite liquor improves the production and saccharification performance of cellulase by Penicillium oxalicum. Bioresource Technology 245 (2017): 984-992.
22. Combining manipulation of transcription factors and overexpression of the target genes to enhance lignocellulolytic enzyme production in Penicillium oxalicum,Biotechnol Biofuels, (2017) 10:100.
23. Production of sodium gluconate from delignified corn cob residue by on-site produced cellulase and co-immobilized glucose oxidase and catalase. Bioresource Technology 248 (2017): 248-257.
24. Constitutive Expression of Chimeric Transcription Factors Enables Cellulase Synthesis under Non-Inducing Conditions inPenicillium oxalicum.Biotechnol. J. 2017, DOI: 10.1002/biot.201700119
25. Production of highly efficient cellulase mixtures by genetically exploiting the potentials ofTrichoderma reeseiendogenous cellulases for hydrolysis of corncob residues. Microbial Cell Factories, 2017, 16:207.
26. Production of the versatile cellulase for cellulose bioconversion and cellulase inducer synthesis by genetic improvement of Trichoderma reesei.Biotechnology for Biofuels, 2017, 10:272.
27. Differential reinforcement of enzymatic hydrolysis by adding chemicals and accessory proteins to high solid loading substrates with different pretreatments. Bioproc Biosyst Eng, 2018, 41:1153–1163.
28. Consolidated bioprocessing for sodium gluconate production from cellulose using Penicillium oxalicum，Bioresour Technol, 2018, 251: 407-410.
29. The cellulose binding region in Trichoderma reesei cellobiohydrolase I has a higher capacity in improving crystalline cellulose degradation than that ofPenicillium oxalicum,Bioresource Technology 2018,266:19-25.
30. 非粮生物质炼制技术—木质纤维素生物降解机理及其酶系合成调控，2017，化学工业出版社.
Honors and awards
“Biological bleaching and Enzymatic Modification of Wheat Straw Pulp”was awarded“Second Prize of National Science and TechnologyProgress”in 2005.
“Technology and application of cellulosic ethanol production by corn cob residue”was awarded“Second Prize of National Technology Invention”in 2011.
Patents
The manufacturing method of high activity cellulase，ZL 96 1 16049.7
The process of improving the performance of straw pulp by xylanase，ZL 95 1 12261.4
The method of producing cellulosic alcohol by fermentation of corn cob residue，ZL 2006 1 0131965.X
APenicillium oxalicum strain which can increase the activity of cellulase and hemicellulase，ZL 201410160118.0
Akind of extracellular aldonolactonase PoALAC and its application, ZL2016 1 1056999.7
