Phone number：+86-15069110069
Fax number：
E-mail：xiayongzhen2002@sdu.edu.cn
Title: Assoicate Professor
EDUCATION
2008-2012，Ph.D Shandong University ,
2006-2008，Master Shandong University
2002-2006，Bachelor Shandong Unversity
WORK EXPERIENCE
2012.07-2018.09 Assistant professor in life science school of Shandong Unversity
2018.09-until now Associated professor in life science school of Shandong Unversity
RESEARCH INTERESTS
1. Bacterial Recombination System
2. Biotechnology Methods Development
3. Sulfur Oxidation of Heterotrophic Bacteria
RESEARCH PROGRAMS
1. Molecular Mechanism of a Novel Sulfide Oxidation Pathway in Heterotrophic Bacteria for Its Regulation and Metabolism,31870085,2019/01-2022/12, National Natural Science Foundation of China, Presiding, Being researching
2. Synthetic biology of natural products of microorganisms based on the characteristics of drug resistance, 2018YFA0902002, 2019/07-2024/06, National key research and development program, Participation, International (regional) cooperation and exchange program of the national nature foundation of China, Being researching
3. Synthetic plastics degradation and transformation microbial flora, Just approved, 2021/01-2025/12, Participation, Being researching
4. The formation of linear DNA molecule with homologous ends in QuikChangeTM site-directed mutagenesis, 31500047, 2016/01-2018/12, Natural Science Foundation Youth Fund, Presiding, Finished
5. The strand displacement of DNA polymerase in QuikChangeTM site-directed mutagenesis and its applications, BS2015SW003, 2015/07-2017/07, Shangdong Province Young and Middle-Aged Scientists Research Awards Fund, Presiding, Finished
SELECTED PUBLICATIONS
1. Yongzhen Xia, Li Kai, Li Jingjing, Wang Tianqi, Gu Lichuan*#, Xun Luying*#. T5 exonuclease-dependent assembly offers a low-cost method for efficient cloning and site-directed mutagenesis, Nucleic Acids Res., 2019, 47(3):e15 (5 year IF=10.235,独立一作)
2. Yongzhen Xia, Chuanjuan Lü, Ningke Hou,Yufeng Xin,Jihua Liu, Honglei Liu*#, Luying Xun*#, Sulfide production and oxidation by heterotrophic bacteria under aerobic conditions. ISME J., 2017, Dec;11(12):2754-2766.
3. Yongzhen Xia, Wenqiao Chu, Qingsheng Qi, Luying Xun*, New insights into the QuikChangeTM process guide the use of Phusion DNA polymerase for site-directed mutagenesis, Nucleic Acids Res., 2015, 43(2):e12
4. Chen Zhigang, Zhang Xi, Li Huanjie, Liu Huaiwei,Xia Yongzhen*#, Xun Luying*#, The Complete Pathway for Thiosulfate Utilization in Saccharomyces cerevisiae. Appl Environ Microbiol. 2018 Oct 30;84(22).
5. Kai Li, Yufeng Xin, Guanhua Xuan, Rui Zhao, Huaiwei Liu,Yongzhen Xia*#, Luyng Xun*#. Escherichia coli uses different enzymes to produce H2S and reactive sulfane sulfur from L-cysteine. Front Microbiol. 2019 Feb 20;10:298.
6. Yongzhen Xia, Jan Hendrik Wübbeler, Qingsheng Qi, Alexander Steinbüchel*, Employing a recombinant strain of Advenella mimigardefordensis for biotechnical production of Homopolythioesters from 3,3'-dithiodipropionic acid., Appl. Environ. Microbiol. 2012, 78, 3286-3297
