Education
Degree |
Date |
Affiliation |
Major |
PhD |
2007.9-2012.6 |
Shandong University |
Microbiology |
Bachelor |
2003.9-2007.6 |
Shandong University |
Biotechnology |
Research Experience
Date |
Affiliation |
Position |
2018.9- |
Shandong University |
Associate Professor |
2016.6-2018.8 |
Shandong University |
Assistant Professor |
2013.8-2016.6 |
Chalmers University of Technology, Sweden |
Post-doc Researcher |
2012.7-2013.6 |
Shandong University |
Research Assistant |
Research Interests
1. Mechanisms for transcriptionalregulation in fungi
2. Systems biology and synthetic biology of fungi
3. Development of highly efficient lignocellulolytic enzyme systems
Research Projects
1. National Natural Science Foundation of China, No.31700062,2018.1-2020.12, PI
2. Young Scholars Program of Shandong University,2018.7-2023.6, PI
3. Open Funding Project of the State Key Laboratory of Bioreactor Engineering, 2018.9-2020.8, PI
4. Shandong Provincial Natural Science Foundation, No.ZR2017BC088, 2017.8-2019.12, PI
5. China Postdoctoral Science Foundation, No.2017M612260,2017.6-2018.12, PI
6. Shandong Postdoctoral Innovation Project, No.201701008,2017.9-2018.12, PI
7. Fundamental Research Funds of Shandong University, No. 2016GN022,2016.7-2018.12, PI
Representative Publications
(* Corresponding authors)
1. Liu G, Qu Y*. Engineering of filamentous fungi for efficient conversion of lignocellulose: Tools, recent advances and prospects.Biotechnol Adv, 2019, 37:519–529.
2. Gao L, Li S, Xu Y, Xia C, Xu J, Liu J, Qin Y, Song X*,Liu G*, Qu Y. Mutation of a conserved alanine residue in transcription factor AraR leads to hyper‐production of α‐L‐arabinofuranosidases inPenicillium oxalicum.Biotechnol J, 2019, 14:1800643.
3. Bergenholm D,Liu G, Holland P, Nielsen J*. Reconstruction of a global transcriptional regulatory network for control of lipid metabolism in yeast by using chromatin immunoprecipitation with lambda exonuclease digestion.mSystems, 2018, 3:e00215-17.
4. Du J, Zhang X, Li X, Zhao J,Liu G*, Gao B, Qu Y. The cellulose binding region inTrichoderma reesei cellobiohydrolase I has a higher capacity in improving crystalline cellulose degradation than that ofPenicillium oxalicum. Bioresour Technol, 2018, 266:19–25.
5. Qu J, Zhu J,Liu G*, Qu Y. Identification of key components for the optimization of cellulase mixtures using a proteomic strategy. In: Lübeck M. (eds) Cellulases. Methods Mol Biol, 2018, 1796. Humana Press, New York, NY (Book Chapter)
6. Hu Y, Qin Y,Liu G*. Collection and curation of transcriptional regulatory interactions inAspergillus nidulans andNeurospora crassa reveal structural and evolutionary features of the regulatory networks. Front Microbiol, 2018, 9:27.
7. Gao L, Xia C, Xu J, Li Z, Yu L,Liu G*, Song X*, Qu Y. Constitutive expression of chimeric transcription factors enables cellulase synthesis under non-inducing conditions inPenicillium oxalicum. Biotechnol J, 2017, 12(11):1700119.
8. Peng S, Cao Q, Qin Y, Li X,Liu G*, Qu Y. An aldonolactonase AltA fromPenicillium oxalicum mitigates the inhibition of β-glucosidase during lignocellulose biodegradation. Appl Microbiol Biotechnol, 2017, 101(9):3627–3636.
9. Liu G, Chen Y, Færgeman NJ, Nielsen J*.Elimination of the last reactions in ergosterol biosynthesis alters the resistance ofSaccharomyces cerevisiae to multiple stresses, FEMS Yeast Res, 2017, 17(6): fox063.
10. Liu G, Bergenholm D, Nielsen J*. Genome-wide mapping of binding sites reveals multiple biological functions of the transcription factor Cst6p inSaccharomyces cerevisiae. mBio, 2016, 7(3):e00559-16.
11. Rajkumar AS,Liu G, Bergenholm D, Arsovska D, Kristensen M, Nielsen J, Jensen MK*, Keasling JD. Engineering of synthetic, stress-responsive yeast promoters. Nucleic Acids Res, 2016, 30;44(17):e136.
12. Liu G, Marras A, Nielsen J*. The future of genome-scale modeling of yeast through integration of a transcriptional regulatory network. Quant Biol, 2014, 2(1):30–46.
13. Li J,Liu G*, Chen M, Li Z, Qin Y, Qu Y*. Cellodextrin transporters play important roles in cellulase induction in the cellulolytic fungusPenicillium oxalicum. Appl Microbiol Biotechnol, 2013, 97(24):10479–10488.
14. Liu G, Qin Y, Li Z, Qu Y*. Development of highly efficient, low-cost lignocellulolytic enzyme systems in the post-genomic era. Biotechnol Adv, 2013, 31(6):962–975.
15. Liu G, Qin Y, Li Z, Qu Y*. Improving lignocellulolytic enzyme production withPenicillium: from strain screening to systems biology. Biofuels, 2013, 4(5):523–534.
16. Liu G, Zhang L, Wei X, Zou G, Qin Y, Ma L, Li J, Zheng H, Wang S, Wang C, Xun L, Zhao GP, Zhou Z*, Qu Y*. Genomic and secretomic analyses reveal unique features of the lignocellulolytic enzyme system ofPenicillium decumbens. PLOS ONE, 2013, 8(2): e55185.
17. Liu G, Qin Y, Hu Y, Gao M, Peng S, Qu Y*. An endo-1,4-β-glucanase PdCel5C from cellulolytic fungusPenicillium decumbens with distinctive domain composition and hydrolysis product profile. Enzyme Microb Technol, 2013, 52(3):190–195.
18. Liu G, Wei X, Qin Y*, Qu Y*. Characterization of the endoglucanase and glucomannanase activities of a glycoside hydrolase family 45 protein fromPenicillium decumbens 114-2. J Gen Appl Microbiol, 2010, 56(3):223–229.
Honors and awards
2018.7Young Scholars Program of Shandong University (YSPSDU)
2018.6Second Oral Presentation Award, National Postdoctoral Academic Forum, Shanghai
2016.10 Best Poster Presentation Award, the 13th International Symposium on the Genetics of Industrial Microorganisms, Wuhan
2015.12 Biotechnology Journal Best Poster Presentation Award, Metabolic Engineering Summit, Beijing
Patents
Qu Y, Peng S,Liu G, Li X. An extracellular aldonolactonase PoALAC and its application.2017.9, Patent No.ZL 2016 1 1056999.7
