Education
Degree |
Date |
Affiliation |
Major |
Ph.D |
2006.09-2011.06 |
Shandong university Max Planck Institute of Biophysics |
Microbiology |
Bachelor |
2002.09-2006.06 |
Shandong normal university |
Biology |
Research Experience
Date |
Affiliation |
Position |
2012.2-2017.8 |
Shandong university |
lecturer |
2017.9-present |
Shandong university |
Vice professor |
Research Interests
1) Molecular mechanism of efficient protein synthesis and secretion in the filamentous fungusTrichoderma reesei
2) Engineering of the filamentous fungusTrichoderma reesei for high-yield production of heterologous proteins
3) Regulatory network of cellulase gene expression inTrichoderma reesei
ResearchProjects
National natural science foundation of China,Structural and functional characterization of a cellobiose transporter from Trichoderma reeseias well as its role in the regulation of cellulase gene expression, 2014.1-2016.12
National natural science foundation of China, Study on the role of the transcriptional corepressor Cyc8-Tup1 in the transcriptional activation of cellulase genes inTrichoderma reesei, 2018.1-2021.12
Publication
1. WangL, Lv X, Cao Y, Zheng F, Meng X, Shen Y, Chen G, Liu W*, Zhang W*. A novel transcriptional regulator RXE1 modulates the essential transactivator XYR1 and cellulase gene expression inTrichoderma reesei, Applied Microbiology and Biotechnology (2019) 103:4511–4523.
2. Wang X(#), Zhang W(#), Zhou H, Chen G*, Liu W*. An extracytoplasmic function sigma factor controls cellulose utilization by regulating the expression of an outer membrane protein inCytophaga hutchinsonii. Applied and Environmental Microbiology. 2019, 85(5).
3. Wang X, Han Q, Chen G, Zhang W*, Liu W.A Putative Type II Secretion System Is Involved in Cellulose Utilization in Cytophaga hutchisonii. Frontiers in Microbiology.8, 1482
4. Cao Y, Zheng F, Wang L, Zhao G, Chen G, Zhang W*, Liu W*. Rce1, a novel transcriptional repressor, regulates cellulase gene expression by antagonizing the transactivator Xyr1 inTrichoderma reesei. Molecular Microbiology. 105(1):65-83
5. Zhang W, Cao Y, Chen G, Liu W. Identification of the structural determinants for efficient glucose transport via segment swapping between two fungal glucose transporters. RSC advances. 2017 7:25109-25117.
6. Yang T, Bu X, Han Q, Wang X, Zhou H, Chen G, Zhang W*, Liu W. A small periplasmic protein essential for Cytophaga hutchinsonii cellulose digestion. Appl Microbiol Biotechnol. 2016 Feb;100(4):1935-44.
7. Zhang W, Cao Y, Gong J, Bao X, Chen G, Liu W*. Identification of residues important for substrate uptake in a glucose transporter from the filamentous fungusTrichoderma reesei. Scientific reports 2015, 5:13829.
8. Lv X(#), Zhang W(#), Chen G, Liu W*.Trichoderma reeseiSch9 and Yak1 regulate vegetative growth, conidiation, and stress response and induced cellulase production. Journal of Microbiology 2015，53(4):236-242
9. Kou Y, Xu J, Cao Y, Lv X, Zhao G, Chen G, Zhang W*, Liu W. 2014 Gluconolactone induces cellulase gene expression in cellulolytic filamentous fungusTrichoderma reesei. RSC advances 2014, 4, 36057-36063.
10. Zhang W, Kou Y, Xu J, Cao Y, Zhao G, Shao J, Wang H, Wang Z, Bao X, Chen G, Liu W*. Two Major Facilitator Superfamily Sugar Transporters from Trichoderma reeseiand Their Roles in Induction of Cellulase Biosynthesis. Journal of Biological Chemistry 2013, 288:32861-32872.
