Xia Wang

Release date:2019-06-21    Author:     Editor: liyuan    Click:









Shandong University

Fermentation engineering



Wuxi Universityof Light Industry

Fermentation engineering



Shandong Institute of Light Industry

Fermentation engineering

Research Experience





Shandong University



Washington State University

Visiting Scholar


Shandong University

Associate Professor


Shandong University



Shandong University


Research Interests

1.Bioremediation and utilization of environmental pollutants

Bioremediation and utilization of environmental pollutants include the application of nanotechnology inenvironmentalpollutants and heavy metals bioremediation, the biodegradation of environmental pollutants in microbial fuel cells,and the extracellular electron transport mechanism ofelectroactive microorganisms.

2. Construction of biosensor based on nanomaterials

The immobilization of enzymes, microbial cells, and using nanomaterials as supports;the construction of biosensors based on the biocomposites constructed by nanomaterials and enzyme, microbial cells orantigen/antibody; the application of resulted biosensors in environmentalpollutants monitoring, food safety detection, and medical diagnosis.

Research Projects

1.2017.01-2019.12, Study on theoperational characteristic and mechanism of microfiltration bioreactor,The Fundamental Research Funds of Shandong University.

2.2016.01-2019.12,Microbial biosensor construction based on the expression of sulfide:quinone oxidoreductase for sulfide detection, National Natural Science Foundation of China.

3.2014.01-2016.12,Biosensor constructionbased on horseradish peroxidase-nanoporous gold and selective determination of phenols and aromatic amines in wastewater, Shandong Science & Technology Fund Planning Project.

4.2012.01-2015.12,Biodegradation of organic pollutants by microbial cells/nanoparticles biocomposite, National Natural Science Foundation of China.

5.2010.10-2013.10, Study on degradation of hexavalent chromium by nanoparticle/microbial cells biocomposites, Excellent Middle-Aged and Youth Scientist Award Foundation of Shandong Province.

6.2008.01-2008.12,Structured kinetic study on the fermentation of gellan gum, National Natural Science Foundation of China.

7.2006.12-2010.12,Glutamine production byCorynebacterium glutamicum and optimization control of fermentation process, 863 Hi-Tech Research and Development Program of China.

Representative Publications

1. Zhang Yachao, Gao Yan, Zhang Xueli, Wang Huiming, Xia Tian, Bian Congcong, Liang Shuang, Tang Xiaozhi,Wang Xia*. Electrochemical immunosensor for HBe antigen detection based on a signal amplification strategy: The co-catalysis of horseradish peroxidase and nanoporous gold.Sens. Actuators B Chem., 2019, 284(4): 296-304.

2. Liu Zhuang, Zhang Yachao, Bian Congcong, Xia Tian, Gao Yan, Zhang Xueli, Wang Huimin, Ma Hanyue, Hu Yuan,Wang Xia*. Highly sensitivemicrobial biosensor based on recombinantEscherichia coli overexpressing catechol 2,3-dioxygenase for reliable detection of catechol.Biosens. Bioelectron., 2019, 126(2), 51-58.

3. Ma Hanyue, Xia Tian, Bian Congcong, Sun Huihui, Liu Zhuang, Wu Chao,Wang Xia*, Xu Ping.Bacterial electroactivity and viability depends on the carbon nanotube-coated sponge anode used in a microbial fuel cell.Bioelectrochemistry, 2018, 122(8): 26-31.

4. Liu Zhuang, Ma Hanyue, Sun Huihui, Gao Rui, Liu Honglei,Wang Xia*, Xu Ping, Xun Luying. Nanoporous gold-based microbial biosensor for direct determination of sulfide.Biosens. Bioelectron., 2017, 98(12), 29-35.

5. Sun Huihui, Ma Hanyue, Liu Zhuang, Li Yufei, Xu Ping,Wang Xia*. Effect of Fe3O4 nanoparticles onSphingobium yanoikuyae XLDN2-5 cells in carbazole biodegradation.Nanotechnol. Environ. Eng., 2017, 2(12): 5.

6. Sun Huihui, Liu Zhuang, Wu Chao, Xu Ping,Wang Xia*. Amperometric inhibitive biosensor based on horseradish peroxidase-nanoporous gold for sulfide determination.Sci. Rep., 2016, 6(9), 30905.

7.Wu Chao, Liu Zhuang, Sun Huihui,Wang Xia*, Ping Xu. Selective determination of phenols and aromatic amines based on horseradish peroxidase-nanoporous gold co-catalytic strategy.Biosens. Bioelectron., 2016, 79(3), 843-849.

8.Sattler Steven A,Wang Xia, Lewis Kevin M, DeHan Preston J, Park Chung-Min, Xin Yufeng, Liu Honglei, Xian Ming, Xun Luying*, Kang ChulHee*. Characterizations of two bacterial persulfide dioxygenases of the metallo-β-lactamase superfamily.J. Biol. Chem., 2015,290(31), 18914-18923.

9. Wu Chao, Sun Huihui, Li Yufei, Liu Xueying, Du Xiaoyu,Wang Xia*, Xu Ping. Biosensor based on glucose oxidase-nanoporous gold co-catalysis for glucose detection. Biosens. Bioelectron., 2015, 66(4), 350-355.

10. Wu Chao, Liu Xueying, Li Yufei, Du Xiaoyu,Wang Xia*, Xu Ping. Lipase-nanoporous gold biocomposite modified electrode for reliable detection of triglycerides.Biosens. Bioelectron., 2014, 53(3), 26-30.

11.Liu Xueying, Du Xiaoyu,Wang Xia*, Li Naiqiang, Xu Ping, Ding Yi. Improved microbial fuel cell performance by encapsulating microbial cells with a nickel-coated sponge.Biosens. Bioelectron.,2013, 41(3), 848-851.

12.Du Xiaoyu, Liu Xueying,Li Yufei,Wu Chao,Wang Xia*, Xu Ping. Efficient biocatalyst by encapsulating lipase into nanoporous gold.Nanoscale Res. Lett., 2013, 8(1), 180-185.

13. Li Yufei, Du Xiaoyu, Wu Chao, Liu Xueying,Wang Xia*, Xu Ping. An efficient magnetically modified microbial cell biocomposite for carbazole biodegradation.Nanoscale. Res. Lett., 2013, 8(1), 522-526.

14.Tao Fei#,Wang Xia#, Cuiqing Ma, Chunyu Yang, Tang Hongzhi, Gai Zhonghui, Xu Ping*. Genome Sequence ofXanthomonas campestris JX, anindustrially productivestrain forxanthangum.J. Bacteriol., 2012, 194(17), 4755-4756.(#these authors contributed equally to this work)

15. Gai Zhonghui,Wang Xia, Zhang Xiaoyun, Su Fei, Wang Xiaoyu, Tang Hongzhi, Tai Cui, Tao Fei, Ma Cuiqing, Xu Ping *. Genome sequence ofSphingomonas elodea ATCC 31461, a highly productive industrial strain of gellan gum.J. Bacteriol., 2011, 193(24), 7015-7016.

16.Wang Xia, Liu Xueying, Yan Xiuling, Zhao Peng, Ding Yi*, Xu Ping*. Enzyme-Nanoporous gold biocomposite: excellent biocatalyst with improved biocatalytic performance and stability.PLoS One, 2011, 6(9), e24207.

17.Wang Xia, Liu Xueying, Zhao Chuanming, Ding Yi*, Xu Ping*. Biodieselproduction in packed-bed reactors using lipase-nanoparticle biocomposite. Bioresour. Technol., 2011, 102(10), 6352-6355.

18.Wang Xia, Dou Peipei, Zhao Peng, Zhao Chuanming, Ding Yi*, Xu Ping*. Immobilization of lipases onto magnetic Fe3O4 nanoparticles for application in biodiesel production.ChemSusChem, 2009, 2(10), 947-950.

19.Wang Xia, Zhao Chuanming, Zhao Peng, Dou Peipei, Ding Yi, Xu Ping*.Gellan gel beads containing magnetic nanoparticles: An effective biosorbent for the removal of heavy metals from aqueous system.Bioresour. Technol., 2009, 100(7), 2301-2304.

20.Wang Xia, Gai Zhonghui, Yu Bo,Feng Jinhui, Xu Changyong, Yuan Yong, Lin Zhixin, Xu Ping*.Degradation of carbazole by microbial cells immobilized in magnetic gellan gum gel beads.Appl. Environ. Microbiol., 2007, 73(20), 6421-6428.

21.Wang Xia, Yuan Yong, Wang Kainan, Zhang Dezhong, Yang Zhengting, Xu Ping*. Deproteinization of gellan gum produced bySphingomonas paucimobilis ATCC 31461.J. Biotechnol., 2007, 128(2), 403-407.

22.Wang Xia,Xu Ping*, Yuan Yong, Liu Changlong, Zhang Dezhong, Yang Zhengting, Yang Chunyu, Ma Cuiqing.Modeling for gellan gum production bySphingomonas paucimobilis ATCC 31461 in a simplified medium.Appl. Environ. Microbiol., 2006, 72(5), 3367-3374.

Honors andAwards

1. Wang Xia,Shandong Excellent Master's Degree Thesis Guidance Award (2017)

2. Wang Xia,Shandong University Excellent Master's Degree Thesis Guidance Award (2017)

3. Wang Xia,National Excellent Doctoral Dissertation Nomination (2010)

4.Wang Xia,Excellent Doctoral Dissertations in Shandong Province (2009)


1.A method for rapid detection of aromatic pollutants in wastewater by using nano-porous gold/horseradish peroxidase sensor. Patent NoZL201510888274.3, China.

2. The application ofSphingomonas paucimobilis XLJ with high production in gellan gum fermentation.Patent No ZL200610068788.5, China.

3. A Deproteinization method for fermentation liquid in gellan gum fermentation.Patent NoZL200610068787.0, China.

Adress:State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China

Tel: (86)-0532-58631501  (86)-0532-58631597  Post Code: 266237

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