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Quanfeng Liang Professor PhD supervisor/Master's supervisor |
Tel：13573163779 E-mail：liangquanfeng@sdu.edu.cn
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Education
Degree |
Date |
Affiliation |
Major |
PhD |
2002.9–2005.7 |
Institute of Biotechnology, Chinese Academy of Agricultural Sciences |
Biotechnology |
Master |
1999.9–2002.7 |
State Key Laboratory of Microbial Technology, Shandong University |
Microbiology |
Research Experience
Date |
Affiliation |
Position |
2009–Present |
Institute of Biotechnology, Chinese Academy of Agricultural Sciences |
Professor, PhD Supervisor |
2007–2009 |
University of Auckland |
Postdoctoral Researcher |
2005–2007 |
SCION (Ensis) |
Postdoctoral Researcher |
Research Interests
Synthetic Biology and Metabolic Engineering
1.Biosynthesis of High-Value Bio-Based Compounds, Pharmaceuticals, and Materials
·Developed microbial cell factories (e.g., E. coli, Corynebacterium glutamicum, yeast) using metabolic engineering and synthetic biology techniques.
·Key Achievements: Achieved world-leading fermentation yields for engineered strains producing L-threonine, 3-hydroxypropionic acid, and ectoine.
2.Design of Novel Biological Systems and Mechanistic Studies in Synthetic Biology
·Engineered genetic circuits and created polyploid prokaryotic model organisms (e.g., E. coli) to construct high-performance chassis cells.
·Investigated fundamental mechanisms of chromosomal ploidy evolution.
·Key Achievements: Pioneered artificial polyploid strains of E. coli and C. glutamicum.
3.Design and Construction of Synthetic Biology Regulatory Elements and Devices
·Developed synthetic biology components (e.g., quorum sensing-based biosensors), genetic circuits, and logic gates systems.
·Key Achievements: Successfully designed and implemented synthetic biology tools including logic gates, cascade circuits, and population oscillators.
Representative Publications as Corresponding Author (Last Four Years)
Kang F, Gu F, Zhong Y, Cui Z, Liang Q, Qi Q.Expanding the genetic toolkit of Yarrowia lipolytica: Dynamic promoter engineering enables high-titer biosynthesis of 3-hydroxypropionic acid. Bioresour Technol. 2025 May 10;432:132656. doi: 10.1016/j.biortech.2025.132656.
Xin Jin, Sumeng Wang, Yaping Gao, Qingsheng Qi, Quanfeng Liang. Combinatorial metabolic engineering of Escherichia coli to efficiently produce L-threonine from untreated cane molasses. Bioresour Technol . 2025 Jan 10:419:132058. doi: 10.1016/j.biortech.2025.132058.
Xuejing Zhang , Feiyu Wang, Xueping Guo , Liping Qiao, Xiangrui Luo, Li Cui, Quanfeng Liang, Mengmeng Liu, Qingsheng Qi ; Developing a RecT-assisted endogenous CRISPR/SzCas9 system for precise genome editing in Streptococcus zooepidemicus. International Journal of Biological Macromolecules. ,2024 Dec 12;291:138758
Jin X, Wang S, Wang Y, Qi Q, Liang Q. Metabolic engineering strategies for L-Homoserine production in Escherichia coli.Microb Cell Fact. 2024 Dec 19;23(1):338.
Sumeng Wang; Xuanmu Chen; Xin Jin; Fei Gu; Wei Jiang; Qingsheng Qi; Quanfeng Liang; Creating PolyploidEscherichia coliand Its Application in Efficient L-Threonine Production, Advanced Science, 2023, 10(31):e2302417.
Xiaomeng Li; Qingsheng Qi; Quanfeng Liang; Construction of cascade circuits for dynamic temporal regulation and its application to PHB production, Biotechnology for Biofuels and Bioproducts , 2023, 27;16(1):158.
Fei Gu; Wei Jiang; Fangbing Kang; Tianyuan Su; Xiaoya Yang; Qingsheng Qi; Quanfeng Liang; A synthetic population-level oscillator in non-microfluidic environments, Communications Biology, 2023, 13;6(1):515.
Wei Jiang; Xiaoya Yang; Fei Gu; Xiaomeng Li; Sumeng Wang; Yue Luo; Qingsheng Qi; Quanfeng Liang; Construction of Synthetic Microbial Ecosystems and the Regulation of Population Proportion, ACS Synthetic Biology, 2022, 11:538-546.
Sumeng Wang; Wei Jiang; Xin Jin; Qingsheng Qi; Quanfeng Liang; Genetically encoded ATP and NAD(P)H biosensors: potential tools in metabolic engineering, Critical Reviews in Biotechnology, 2022,43(8):1211-1225.
Jiang Wei; He Xinyuan; Luo Yue; Mu Yunlan; Gu Fei; Liang Quanfeng; Qi Qingsheng; Two Completely Orthogonal Quorum Sensing Systems with Self-Produced Autoinducers Enable Automatic Delayed Cascade Control, ACS Synthetic Biology, 2020, 9(9):2588-2599.
Gu, Fei; Jiang, Wei; Mu, Yunlan; Huang, Hao; Su, Tianyuan; Luo, Yue; Liang, Quanfeng; Qi, Qingsheng; Quorum Sensing-Based Dual-Function Switch and Its Application in Solving Two Key Metabolic Engineering Problems, ACS Synthetic Biology, 2020, 9(2):209-217.
Sumeng Wang; Yue Luo; Wei Jiang; Xiaomeng Li; Qingsheng Qi; Quanfeng Liang; Development of Optogenetic Dual-Switch System for Rewiring Metabolic Flux for Polyhydroxybutyrate Production, Molecules, 2022,27(3):617.
Sumeng Wang; Ruxin Hao; Xin Jin; Xiaomeng Li; Qingsheng Qi; Quanfeng Liang; Dynamic Regulation of Transporter Expression to Increase L-Threonine Production Using L-Threonine Biosensors, Fermentation, 2022, 8(6):250-250.
Sumeng Wang; Xin Jin; Wei Jiang; Qian Wang; Qingsheng Qi; Quanfeng Liang; The Expression Modulation of the Key Enzyme Acc for Highly Efficient 3-Hydroxypropionic Acid Production, Frontiers in Microbiology, 2022, 11;13:902848.
Xiaomeng Li; Wei Jiang; Qingsheng Qi; Quanfeng Liang; A Gene Circuit Combining the Endogenous I-E Type CRISPR-Cas System and a Light Sensor to Produce Poly-β-Hydroxybutyric Acid Efficiently, Biosensors, 2022, 12(8):642-642.
Ruxin Hao; Sumeng Wang; Xin Jin; Xiaoya Yang; Qingsheng Qi; Quanfeng Liang; Dynamic and balanced regulation of thethrABCoperon gene for efficient synthesis of L-threonine, Frontiers in Bioengineering and Biotechnology, 2023, 11:1118948.
Xin Jin; Yaping Gao; Xuanmu Chen; Sumeng Wang; Qingsheng Qi; Quanfeng Liang; The Construction of the Self-Induced Sal System and Its Application in Salicylic Acid Production, Molecules, 2023,28(23):7825.
Honors and awards
1. International Gold Medal (Principal Investigator)
Gold Medal (Principal Investigator), International Genetic Engineering Machine (iGEM) Competition, 2018, 2019, and 2023
2. Provincial Science and Technology Award
Second Prize, Shandong Provincial Science and Technology Progress Award
3. National Competition Advisor Recognition
First Prize (Advisor), National College Students Innovation and Entrepreneurship Competition
4. Doctoral Dissertation Supervision Excellence
Outstanding Doctoral Dissertation Supervisor, Shandong University
