Education

Degree	Date	Affiliation	Major
PhD	2009	Shandong University	Microbiology
Bachelor	2004	Shandong University	Biology

Research Experience

Date	Affiliation	Position
2017.12-2018.12	Northeastern University, USA	Visiting scholar
2015-present	Shandong University	Professor
2009-2015	Shandong University	Lecturer

Research Interests

1. Evolution, speciation and adaption of microorganisms

2. Cultivation of “uncultivable” microorganisms and the mechanism underlying uncultivation

3. Discovery of novel enzymes

Research Projects

l 2018-2021, Differentiation in the utilization of polysaccharides byPseudoalteromonas and its genomic basis, the National Natural Science Foundation of China (PI)

l 2016-2021,the Young Scholars Program of Shandong University, Shandong University (PI)

l 2015-2016, Diversity, Classification and Genetic and Physiological Basis for Ecological Adaptation of Arctic Sea IcePseudoalteromonas, the National Natural Science Foundation of China (PI)

l 2014-2017, Assess the role of piezophilic bacteria in carbon cycle of the South China Sea, the National Natural Science Foundation of China (PI: Jisong Fang,Tongji University)

l 2011-2014,A pilot-scale study of a novel elastase, the National High-tech R&D Program of China (863 Program) (PI)

l 2011-2013, Elastolytic mechanism of a novel elastase Pseudoalterin from deep-sea,theNational Natural Science Foundation of China (PI)

l 2011-2013, Discovery of a novel elastase, Specialized Research Fund for the Doctoral Program of Higher Education of China (PI)

l 2010-2012, Study on the structure and function of a novel elastase Pseudoalterin, Research Award Fund for Outstanding Young and Middle-aged Scientists of Shandong Province, China (PI)

l 2010-2011, Evolution of protein intra-molecular interaction networks, Special Funds for Postdoctoral Innovative Projects of Shandong Province, China (PI)

l 2010-2011,Detecting co-evolution of proteins, Innovation Fund of Shandong University (PI)

Representative Publications

15.Liu Q, Fang J*, Li J, Zhang L*, Xie BB*, Chen XL, Zhang YZ (2018) Depth-Resolved Variations of Cultivable Bacteria and Their Extracellular Enzymes in the Water Column of the New Britain Trench.Front Microbiol. 9:135. (*corresponding author)

14.Li, P. Y., Zhang, Y. (Co-first author),Xie, B. B.*, Zhang, Y. Q., Hao, J., Wang, Y., Wang, P., Li, C. Y., Qin, Q. L., Zhang, X. Y., Su, H. N., Shi, M., Zhang, Y. Z., Chen, X. L* (2017) Structural and mechanistic insights into the improvement of the halotolerance of a marine microbial esterase by increasing intra- and interdomain hydrophobic interactions.Appl Environ Microbiol 83, e01286-17. (*corresponding author)

13.Su, H. N., Wang, Q. M., Li, C. Y., Li, K., Luo, W., Chen, B., Zhang, X. Y., Qin, Q. L., Zhou, B. C., Chen, X. L., Zhang, Y. Z., andXie, B. B.* (2017) Structural insights into the cold adaptation of the photosynthetic pigment-protein C-phycocyanin from an Arctic cyanobacterium.Biochim Biophys Acta1858, 325-335 (*corresponding author)

12.Chen, X. L., Dong, S., Xu, F., Dong, F., Li, P. Y., Zhang, X. Y., Zhou, B. C., Zhang, Y. Z., andXie, B. B.* (2016) Characterization of a New Cold-Adapted and Salt-Activated Polysaccharide Lyase Family 7 Alginate Lyase fromPseudoalteromonas sp. SM0524.Frontiers in Microbiology 7, 1120 (*corresponding author)

11.Xie, B. B., Li, D., Shi, W. L., Qin, Q. L., Wang, X. W., Rong, J. C., Sun, C. Y., Huang, F., Zhang, X. Y., Dong, X. W., Chen, X. L., Zhou, B. C., Zhang, Y. Z., and Song, X. Y. (2015) Deep RNA sequencing reveals a high frequency of alternative splicing events in the fungusTrichoderma longibrachiatum.BMC Genomics 16, 54

10.Yang, J., Zhao, H. L., Tang, B. L., Chen, X. L., Su, H. N., Zhang, X. Y., Song, X. Y., Zhou, B. C.,Xie, B. B.*, Weiss, A. S., and Zhang, Y. Z. (2015) Mechanistic insight into the elastin degradation process by the metalloprotease myroilysin from the deep-sea bacteriumMyroides profundi D25.Marine Drugs 13, 1481-1496 (*corresponding author)

9.Li, H., Zhang, X. Y., Liu, C., Liu, A., Qin, Q. L., Su, H. N., Shi, M., Zhou, B. C., Chen, X. L., Zhang, Y. Z., andXie, B. B.* (2015)Bizionia arctica sp. nov., isolated from Arctic fjord seawater, and emended description of the genusBizionia.International Journal of Systematic and Evolutionary Microbiology 65, 2925-2930 (*corresponding author)

8.Xie, B. B., Qin, Q. L., Shi, M., Chen, L. L., Shu, Y. L., Luo, Y., Wang, X. W., Rong, J. C., Gong, Z. T., Li, D., Sun, C. Y., Liu, G. M., Dong, X. W., Pang, X. H., Huang, F., Liu, W., Chen, X. L., Zhou, B. C., Zhang, Y. Z., and Song, X. Y. (2014) Comparative genomics provide insights into evolution ofTrichoderma nutrition style.Genome Biology and Evolution 6, 379-390

7.Su, H. N., Ran, L. Y., Chen, Z. H., Qin, Q. L., Shi, M., Song, X. Y., Chen, X. L., Zhang, Y. Z., andXie, B. B.* (2014) The ultrastructure of type I collagen at nanoscale: large or small D-spacing distribution?Nanoscale 6, 8134-8139 (*corresponding author)

6.Sun, M. L., Liu, S. B., Qiao, L. P., Chen, X. L., Pang, X., Shi, M., Zhang, X. Y., Qin, Q. L., Zhou, B. C., Zhang, Y. Z., andXie, B. B.* (2014) A novel exopolysaccharide from deep-sea bacteriumZunongwangia profunda SM-A87: low-cost fermentation, moisture retention, and antioxidant activities.Applied Microbiology and Biotechnology 98, 7437-7445 (*corresponding author)

5.Zhao, H. L., Yang, J., Chen, X. L., Su, H. N., Zhang, X. Y., Huang, F., Zhou, B. C., andXie, B. B.* (2014) Optimization of fermentation conditions for the production of the M23 protease Pseudoalterin by deep-seaPseudoalteromonas sp. CF6-2 with artery powder as an inducer.Molecules 19, 4779-4790 (*corresponding author)

4.Qin, Q. L.,Xie, B. B.*, Yu, Y., Shu, Y. L., Rong, J. C., Zhang, Y. J., Zhao, D. L., Chen, X. L., Zhang, X. Y., Chen, B., Zhou, B. C., and Zhang, Y. Z.* (2014) Comparative genomics of the marine bacterial genusGlaciecola reveals the high degree of genomic diversity and genomic characteristic for cold adaptation.Environmental Microbiology 16, 1642-1653 (*corresponding author)

3.Li, P. Y.,Xie, B. B.*, Zhang, X. Y., Qin, Q. L., Dang, H. Y., Wang, X. M., Chen, X. L., Yu, J., and Zhang, Y. Z.* (2012) Genetic structure of three fosmid-fragments encoding 16S rRNA genes of the Miscellaneous Crenarchaeotic Group (MCG): implications for physiology and evolution of marine sedimentary archaea.Environmental Microbiology 14, 467-479 (*corresponding author)

2.Xie, B. B.¹, Bian, F.¹, Chen, X. L., He, H. L., Guo, J., Gao, X., Zeng, Y. X., Chen, B., Zhou, B. C., and Zhang, Y. Z. (2009) Cold adaptation of zinc metalloproteases in the thermolysin family from deep sea and arctic sea ice bacteria revealed by catalytic and structural properties and molecular dynamics: new insights into relationship between conformational flexibility and hydrogen bonding.The Journal of Biological Chemistry 284, 9257-9269 (¹co-first author)

1.Xie, B. B., Chen, X. L., Zhang, X. Y., He, H. L., Zhang, Y. Z., and Zhou, B. C. (2008) Predicting protein interaction interfaces from protein sequences: case studies of subtilisin and phycocyanin.Proteins 71, 1461-1474

Honors and awards

2009,Winner of the Shandong University Excellent Doctoral Thesis Award.

2016,Winner of the Young Scholars Program of Shandong University (2016-2021)

2016,Winner of the first prize in theSymposiumof Yong Scholars in the State KeyLaboratory of MicrobialTechnology, China, July 2016.