Pingyi Li Associate Professor Master Supervisor Tel：0532-58632590 E-mail：lipingyipeace@sdu.edu.cn

Education

09/2006-12/2011  PhD, Microbiology, Shandong University

09/2002-07/2006  Bachelor, Biotechnology, Shandong University

Research Experience

06/2018-present   Associate Professor, State Key Laboratory of Microbial Technology, Shandong University

07/2016-05/2018  Associate Professor, Institute of Marine Science and Technology, Shandong University

02/2012-12/2015  Post doctor, School of Chemistry and Chemical Engineering, Shandong University

Research Interests

1.Research on the degradation process of high molecular weight organic matter and underlying mechanism

2.Structural and functional analyses of new enzymes involved in marine organic carbon degradation

3.Physiological and genetic analyses of marine unculturable microorganisms

Research Projects

1. National Natural Science Foundation of China, 42176229, Jan. 2022-Dec. 2025, principal investigator.

2. National Natural Science Foundation of China, 91751101, Jan. 2018-Dec. 2020, principal investigator.

3. National Natural Science Foundation of China, 41676180, Jan. 2017-Dec. 2020, principal investigator.

4. Pilot National Laboratory for Marine Science and Technology (Qingdao), QNLM2016ORP0310, Apr. 2017-Mar. 2020, principal investigator.

5. The Fundamental Research Funds of Shandong University, 2016TB010, July 2016-Dec. 2018, principal investigator.

6. China postdoctoral science foundation, 2013M53158, Aug. 2013-Aug. 2015, principal investigator.

7. Postdoctoral innovation program of Shandong province, Oct. 2013-Oct. 2015, principal investigator.

Representative Publications

1. Jiang WX^#, Li PY^#*, Chen XL, Zhang YS, Wang JP, Wang YJ, Sheng Q, Sun ZZ, Qin QL, Ren XB, Wang P, Song XY, Chen Y, Zhang YZ*. A pathway for          chitin oxidation in marine bacteria. Nat Commun, 2022, 13:5899

2. Qin QL^#, Wang ZB^#, Cha QQ, Liu SS, Ren XB, Fu HH, Sun ML, Zhao DL, McMinn A, Chen Y, Chen XL, Zhang YZ*, Li PY*. Biogeography of culturable      marine bacteria from both poles reveals that ‘everything is not everywhere’ at the genomic level. Environ Microbiol, 2022, 24:98-109

3. Zhang Y^#, Ding HT^#, Jiang WX, Zhang X, Cao HY, Wang JP, Li CY, Huang F, Zhang XY, Chen XL, Zhang YZ*, Li PY*. Active site architecture of an acetyl      xylan esterase indicates a novel cold adaptation strategy. J Biol Chem, 2021, 297:100841

4. Wang Y^#, Li PY^#, Zhang Y, Cao HY, Wang YJ, Li CY, Wang P, Su HN, Chen Y, Chen XL*, Zhang YZ*. 3,6-anhydro-L-galactose dehydrogenase VvAHGD is a member of a new aldehyde dehydrogenase family and catalyzes by a novel mechanism with conformational switch of two catalytic residues cysteine 282 and        glutamate 248. J Mol Biol, 2020, 432:2186-2203

5. Wang YJ, Jiang WX, Zhang YS, Cao HY, Zhang Y, Chen XL, Li CY, Wang P, Zhang YZ, Song XY*, Li PY*. Structural insight into chitin degradation and            thermostability of a novel endochitinase from the glycoside hydrolase Family 18. Front Microbiol, 2019, 10:2457

6. Chen XL^#, Zhao F^#, Yue YS, Zhang XY, Zhang YZ, Li PY*. A new group of modular xylanases in glycoside hydrolase family 8 from marine bacteria. Appl        Environ Microbiol, 2018, 84: e01785-18

7. Li PY^#, Zhang Y^#, Xie BB*, Zhang YQ, Hao J, Wang Y, Wang P, Li CY, Qin QL, Zhang XY, Su HN, Shi M, Zhang YZ, Chen XL*. Structural and mechanistic    insights into the improvement of the halotolerance of a marine microbial esterase by increasing intra- and interdomain hydrophobic interactions. Appl Environ  Microbiol, 2017, 83: e01286~17

8. Li PY^#, Yao QQ^#, Wang P, Zhang Y, Li Y, Zhang YQ, Hao J, Zhou BC, Chen XL*, Shi M, Zhang YZ, Zhang XY*. A novel subfamily esterase with a homoserine transacetylase-like fold but no transferase activity. Appl Environ Microbiol, 2017, 83：e00131~17

9. Li PY, Chen XL, Ji P, Li CY, Wang P, Zhang Y, Xie BB, Qin QL, Su HN, Zhou BC, Zhang YZ, Zhang XY*. Interdomain hydrophobic interactions modulate the  thermostability of microbial esterases from the hormone-sensitive lipase family. J Biol Chem, 2015, 290: 11188~11198

10. Li PY, Ji P, Li CY, Zhang Y, Wang GL, Zhang XY, Xie BB, Qin QL, Chen XL, Zhou BC, Zhang YZ*. Structural basis for dimerization and catalysis of a novel esterase from the GTSAG motif subfamily of the bacterial hormone-sensitive lipase family. J Biol Chem, 2014, 289: 19031~19041

11. Li PY, Xie BB*, Zhang XY, Qin QL, Dang HY, Wang XM, Chen XL, Yu J, Zhang YZ*. Genetic structure of three fosmid-fragments encoding 16S rRNA genes of the Miscellaneous Crenarchaeotic Group (MCG): implications for physiology and evolution of marine sedimentary archaea. Environ Microbiol, 2012, 14: 467~479

Honors and Awards

Young Scholars Program of Shandong University (2017WLJH57)

Patents

1. 一种海洋适冷酯酶及其编码基因E40与应用，第二位。

2. 一种海洋酯酶及其编码基因E32与应用，第二位。