Yuzhong Zhang

Release date:2019-07-01    Author:     Editor: liyuan    Click:








Institute of Oceanology, Chinese Academy of Sciences

Marine botany



Nanjing Agricultural University




Shandong Normal University


Research Experience





The State Key Lab of Microbial Technology, Shandong University



The State Key Lab of Microbial Technology, Shandong University

Associate professor


The State Key Lab of Microbial Technology, Shandong University

Postdoctoral fellow

Research Interests

1. Marine microbiology

l Physiology, biochemistry, diversity, ecology and biotechnology of marine bacteria in the oceanic extreme environments.

l Photosynthesis and evolution of cyanobacteria and red algae.

2. Marine biotechnology

l Application of novel enzymes and exopolysaccharides from marine bacteria.

3. Agricultural Microbiology

l Biology of filamentous fungiTrichoderma spp.

l Biocontrol of plant pathogens byTrichoderma spp. and interaction between plant andTrichoderma spp.

Research Projects

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项 目 名 称
























Representative Publications

1. Qi-Long Qin, Yi Li, Lin-Lin Sun, Zhi-Bin Wang, Shi Wang, Xiu-Lan Chen,Aharon Oren*, Yu-Zhong Zhang*, Trophic specialization results in genomic reduction in free-living marineIdiomarina bacteria. mBio. 2019, 10: e02545-18.

2. Chun-Yang Li, Xiu-Lan Chen, Dian Zhang, Peng Wang, Qi Sheng, Ming Peng, Bin-Bin Xie, Qi-Long Qin, Ping-Yi Li, Xi-Ying Zhang, Hai-Nan Su, Xiao-Yan Song, Mei Shi, Bai-Cheng Zhou, Lu-Ying Xun, Yin Chen,Yu-Zhong Zhang*, Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide.Molecular Microbiology. 2017, 103(6):992–1003.

3. Chun-Yang Li#, Dian Zhang#, Xiu-Lan Chen, Peng Wang, Wei-Ling Shi, Ping-Yi Li, Xi-Ying Zhang, Qi-Long Qin, Jonathan D. Todd,Yu-Zhong Zhang*, Mechanistic Insights into Dimethylsulfoniopropionate Lyase DddY, a New Member of the Cupin Superfamily. Journal of Molecular Biology 2017, 429: 3850–3862.

4. Peng Wang#, Hai-Yan Cao#, Xiu-Lan Chen, Chun-Yang Li, Ping-Yi Li, Xi-Ying Zhang, Qi-Long Qin, Jonathan D. Todd, Yu-Zhong Zhang*, Mechanistic insight into acrylate metabolism and detoxification in marine dimethylsulfoniopropionate-catabolizing bacteria.Molecular Microbiology 2017, 105(5): 674–688.

5. Zhang Y-Z,Li Y, Xie B-B, Chen X-L, Yao Q-Q, Zhang X-Y, Kempher ML, Zhou J, Oren A, Qin Q-L (2016) Nascent Genomic Evolution and Allopatric Speciation of Myroides profundi D25 in Its Transition from Land to Ocean.mBio,7(1): e01946-15. doi:10.1128/mBio.01946-15.

6. Zi-Chao Yu, Xiu-Lan Chen, Qing-Tao Shen, Dian-Li Zhao, Bai-Lu Tang, Hai-Nan Su, Zhao-Yu Wu, Qi-Long Qin, Bin-Bin Xie, Xi-Ying Zhang, Yong Yu, Bai-Cheng Zhou, Bo Chen andYu-Zhong Zhang*,Filamentous phages prevalent inPseudoalteromonas spp. confer properties advantageous to host survival in Arctic sea ice,ISME Journal,2015, 9(4):871-81. doi: 10.1038/ismej.2014.185.

7. Peng Wang, Xiu-Lan Chen, Chun-Yang Li, Xiang Gao, Deyu Zhu, Bin-Bin Xie, Qi-Long Qin, Xi-Ying Zhang, Hai-Nan Su, Bai-Cheng Zhou, Luying Xun andYu-Zhong Zhang*. Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold.Molecular Microbiology.2015, 98(2): 289-301.

8. Zi-Hao Mi, Zi-Chao Yu, Hai-Nan Su, Lei Wang, Xiu-Lan Chen, Xiuhua Pang, Qi-Long Qin, Bin-Bin Xie, Xi-Ying Zhang, Bai-Cheng Zhou andYu-Zhong Zhang*,Physiological and genetic analyses reveal a mechanistic insight into the multifaceted lifestyles ofPseudoalteromonas sp. SM9913 adapted to the deep-sea sediment,Environmental Microbiology,2015 Oct;17(10):3795-806.

9. Li CY, Wei TD, Zhang SH, Chen XL, Gao X, Wang P,Xie BB, Su HN, Qin QL, Zhang XY, Yu J, Zhang HH, Zhou BC, Yang GP,Zhang YZ*. Molecular insight into bacterial cleavage of oceanic dimethylsulfoniopropionate into dimethyl sulfide.Proc Natl Acad Sci U S A. 2014,111: 1026-1031.

10. Xiang Gao, Jue Wang, Da-Qi Yu, Fei Bian, Bin-Bin Xie, Xiu-Lan Chen Bai-Cheng Zhou, Lu-Hua Lai, Zhi-Xin Wang, Jia-Wei Wu*,Yu-Zhong Zhang*, Structural Basis for the Autoprocessing of Zinc Metalloproteases in the Thermolysin Family.Proc Natl Acad Sci U S A 2010, 107(41): 17569-74.

11. Qi-Long Qin, Yang Li, Yan-Jiao Zhang, Zhe-Min Zhou, Wei-Xin Zhang, Xiu-Lan Chen, Xi-Ying Zhang, Bai-Cheng Zhou, Lei Wang andYu-Zhong Zhang*, Comparative genomics reveals a deep-sea sediment-adapted life style of Pseudoalteromonas sp. SM9913,The ISME Journal , 2011, 5(2): 274-84.

12. Ran LY, Su HN, Zhao GY, Gao X, Zhou MY, Wang P, Zhao HL, Xie BB, Zhang XY, Chen XL, Zhou BC,Zhang YZ*. Structural and Mechanistic Insights into Collagen Degradation by a Bacterial Collagenolytic Serine Protease in the Subtilisin Family.Molecular Microbiology, 2013, 90(5): 997-1010.

13. Xiang Gao, Tian-Di Wei, Nan Zhang, Bin-Bin Xie, Hai-Nan Su, Xi-Ying Zhang, Xiu-Lan Chen,Yu-Zhong Zhang*.Molecular insights into the terminal energy acceptor in cyanobacterial phycobilisome,Molecular Microbiology, 2012, 85(5): 907-915.

14. Xiang Gao, Nan Zhang, Tian-Di Wei, Hai-Nan Su, Bin-Bin Xie, Chuang-Chuang Dong, Xi-Ying Zhang, Xiu-Lan Chen, Bai-Cheng Zhou Zhi-Xin Wang, Jia-Wei Wu,Yu-Zhong Zhang*, Crystal Structure of the N-terminal Domain of Linker LR and the Assembly of Cyanobacterial Phycobilisome Rods.Molecular Microbiology, 2011, 82: 698-705.

15. Ping-Yi Li, Peng Ji, Chun-Yang Li, Yi Zhang, Guang-Long Wang, Xi-Ying Zhang,Bin-Bin Xie,Qi-Long Qin, Xiu-Lan Chen, Bai-Cheng Zhou, and Yu-Zhong Zhang*.Structural Basis for Dimerization and Catalysis of a Novel Esterase from the GTSAG Motif Subfamily of the Bacterial Hormone-sensitive Lipase Family.Journal of Biological Chemistry, 2014, 289: 19031-19041.

16. Ran LY, Su HN, Zhou MY, Wang L, Chen XL, Xie BB, Song XY, Shi M, Qin QL, Pang X, Zhou BC, Zhang YZ*, Zhang XY*. Characterization of a Novel Subtilisin-like Protease Myroicolsin from Deep sea bacterium Myroides profundi D25 and Molecular insight into its Collagenolytic Mechanism.Journal of Biological Chemistry, 2014, 289(9): 6041-6053.

17. Hui-Lin Zhao,Xiu-Lan Chen,Bin-Bin Xie,Ming-Yang Zhou,Xiang Gao,Xi-Ying Zhang,Bai-Cheng Zhou,Anthony S. Weiss andYu-Zhong Zhang*, Elastolytic mechanism of a novel M23 metalloprotease pseudoalterin from deep-sea Pseudoalteromonas sp. CF6-2: cleaving not only glycyl bonds in the hydrophobic regions, but also peptide bonds in the hydrophilic regions involved in crosslinking,Journal of Biological Chemistry, 2012, 2012 Nov 16;287(47):39710-20

18. Yu-Kai Wang, Guo-Yan Zhao (co-first author), Yang Li, Xiu-Lan Chen, Bin-Bin Xie, Hai-Nan Su, Yao-Hui Lv, Hai-Lun He, Hong Liu, Jun Hu, Bai-Cheng Zhou,Yu-Zhong Zhang*, Mechanistic insight into the function of the C-terminal PKD domain of the collagenolytic serine protease deseasin MCP-01 from deep-sea Pseudoalteromonas sp. SM9913: Binding of the PKD domain to collagen results in collagen swelling but does not unwind the collagen triple helix,Journal of Biological Chemistry, 2010, 285(19):14285-91

19. Bin-Bin Xie, Fei Bian, Xiu-Lan Chen, Hai-Lun He, Jun Guo, Xiang Gao, Yin-Xin Zeng, Bo Chen, Bai-Cheng Zhou, andYu-Zhong Zhang*, Cold adaptation of zinc metalloproteases in the thermolysin family from deep-sea and Arctic sea-ice bacteria revealed by catalytic and structural properties and molecular dynamics: New insights into relationship between conformational flexibility and hydrogen-bonding,Journal of Biological Chemistry, 2009, 284: 9257-9269.

20. Guo-Yan Zhao, Xiu-Lan Chen (co-first author), Hui-Lin Zhao, Bin-Bin Xie, Bai-Cheng Zhou,Yu-Zhong Zhang*, Hydrolysis of insoluble collagen by deseasin MCP-01 from deep-sea Pseudoalteromonas sp. SM9913: Collagenolytic characters, collagen-binding ability of C-terminal PKD domain and Implication for its novel role in deep-sea sedimentary particulate organic nitrogen degradation,Journal of Biological Chemistry,2008, 283 (52): 36100-36107.

Honors and awards

1. National Natural Science Outstanding Youth Fund of 2010

2. thefirst prize ofNatural Science in the Ministry of Education of 2018(thefirst winner).

3. Taishan scholar from 2009

4.the New Century Outstanding Talent ofthe Ministry of Education of 2005.


More than20 National Invention Patents have been authorized.

Adress:State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China

Tel: (86)-0532-58631501  (86)-0532-58631597  Post Code: 266237

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