Education
Degree |
Date |
Affiliation |
Major |
PhD |
1998.9-2002.6 |
Shandong University |
Microbiology |
Master |
1989.9-1992.6 |
Shandong Normal University |
Botany |
Bachelor |
1985.9-1989.6 |
Shandong Normal University |
Biology |
Research Experience
Date |
Affiliation |
Position |
2004.9-present |
The State Key Lab of Microbial Technology, Shandong University |
professor |
2002.9-2004.8 |
The State Key Lab of Microbial Technology, Shandong University |
Associate professor |
1998.10-2002.8 |
The State Key Lab of Microbial Technology, Shandong University |
Lecturer |
1992.7-1998.9 |
Cotton Research Center, Shandong Academy of Agricultural Sciences |
Assistant researcher |
Research Interests
1. Diversity of marine extracellular enzyme producing bacteria.
2. Structure, catalytic mechanism and application of marine bacterial enzymes.
3. Degradation mechanism of marine organic matters.
Research Projects
时 间 |
项 目 名 称 |
等级 |
位次 |
经费（万） |
2018-2021 |
深海热液区微生物功能基因与酶应用潜力评价 |
国家重点研发计划课题 |
1 |
405 |
2017-2020 |
诱导细菌胞外蛋白酶表达的胞外诱导物和细胞膜上的信号感应受体研究 |
国家自然基金 |
1 |
68 |
2019-2022 |
海洋细菌来源的PL14家族褐藻胶裂解酶的性质、结构与催化机制 |
国家自然基金 |
1 |
59 |
Representative Publications
1. Fei Xu, Peng Wang, Yu-Zhong Zhang, Xiu-Lan Chen*，Diversity of Three-Dimensional Structures and CatalyticMechanisms of Alginate Lyases.Appl Environ Microbiol,2018, 84: e02040-17.
2. Xiu-Lan Chen#, Fang Zhao#, Yong-Sheng Yue, Xi-Ying Zhang, Yu-Zhong Zhang, Ping-Yi Li*, A New Group of Modular Xylanases in Glycoside Hydrolase Family 8 from Marine Bacteria.Appl Environ Microbiol, 2018, 84: e01785-18.
3. Fei Xu, Fang Dong, Peng Wang, Hai-Yan Cao, Chun-Yang Li, Ping-Yi Li, Xiu-Hua Pang, Yu-Zhong Zhang, andXiu-Lan Chen*. Novel molecular insights into the catalytic mechanism of marine bacterial alginate lyase AlyGC from polysaccharide lyase family 6.J Biol Chem, 2017, 292:4457-4468.
4. Ping-Yi Li, Qiong-Qiong Yao, Peng Wang, Yi Zhang, Yue Li, Yan-Qi Zhang, Jie Hao, Bai-Cheng Zhou,Xiu-Lan Chen*, Mei Shi, Yu-Zhong Zhang, Xi-Ying Zhang*,A Novel Subfamily Esterase with a Homoserine Transacetylase-like Fold but No Transferase Activity.Appl Environ Microbiol, 2017, 83(9): e00131-17.
5. Ping-Yi Li#, Yi Zhang#, Bin-Bin Xie*, Yan-Qi Zhang, Jie Hao, Yue Wang,Peng Wang, Chun-Yang Li, Qi-Long Qin, Xi-Ying Zhang, Hai-Nan Su, Mei Shi,Yu-Zhong Zhang,Xiu-Lan Chen*, Structural and Mechanistic Insights intothe Improvement of the Halotoleranceof a Marine Microbial Esterase byIncreasing Intra- and InterdomainHydrophobic Interactions.Appl Environ Microbiol, 2017, 83: e01286-17.
6. Hai-Yan Cao#, Peng Wang #,Fei Xu,Ping-Yi Li,Bin-Bin Xie, Qi-Long Qin; Yu-Zhong Zhang,Chun-Yang Li*,Xiu-Lan Chen*, Molecular Insightinto the Acryloyl-CoA Hydration by AcuH for Acrylate Detoxification in Dimethylsulfoniopropionate-Catabolizing Bacteria.Front Microbiol, 2017, 8:2034.
7. Chun-Yang Li,Xiu-Lan Chen, D Zhang, P Wang, Qi Sheng, Ming Peng, Bin-Bin Xie, Qi-Long Qin, Ping-Yi Li, Xi-Ying Zhang, Hai-Nan Su, Xiao-Yan Song, Mei Shi, Bai-Cheng Zhou, Lu-Ying Xun, Yin Chen, and Yu-Zhong Zhang*. Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamineN-oxide.Mol Microbiol, 2017, 103:992-1003.
8. Peng Wang#, Hai-Yan Cao#,Xiu-Lan Chen, Chun-Yang Li, Ping-Yi Li, Xi-Ying Zhang, Qi-Long Qin, Jonathan D. Todd and Yu-Zhong Zhang*. Mechanistic insight into acrylate metabolism and detoxification in marine dimethylsulfoniopropionate-catabolizing bacteria.Mol Microbiol, 2017, 105:674–688.
9. Chun-Yang Li#, Dian Zhang#,Xiu-Lan Chen, Peng Wang, Wei-Ling Shi, Ping-Yi Li, Xi-Ying Zhang, Qi-Long Qin, Jonathan D. Todd, Yu-Zhong Zhang*, Mechanistic Insights into Dimethylsulfoniopropionate Lyase DddY, a New Member of the Cupin Superfamily.J Mol Biol, 2017, 429:3850–3862.
10. Yu-Zhong Zhang*, Yi Li, Bin-Bin Xie, Xiu-Lan Chen, Qiong-Qiong Yao, Xi-Ying Zhang, Megan L. Kempher, Jizhong Zhou, Aharon Oren, and Qi-Long Qin*. Nascent genomic evolution and allopatric speciation ofMyroides profundiD25 in its transition from land to ocean.mBio, 2016,7:e01946-15.
Honors and awards
1. the New Century Outstanding Talent of the Ministry of Education of 2006.
2. the second prize of Natural Science in Shandong Province of 2018 (the first winner).
3. the first prize of Natural Science in the Ministry of Education of 2018 (the second winner).
Patents
More than 10 National Invention Patents have been authorized.
