Education
Degree |
Date |
Affiliation |
Major |
PhD |
2016.06 |
Shanghai institute of Organic Chemistry, Chinese Academy of Sciences |
Organic chemistry |
Bachelor |
2011.06 |
Shandong University |
Chemistry |
Research Experience
Date |
Affiliation |
Position |
2019.02-Now |
Shandong University |
Assistant professor |
2018.06-2019.02 |
Shandong University |
Assistant professor |
2017.06-2018.05 |
Zhejiang University of Technology |
Assistant professor |
2016.07-2017.05 |
Shanghai institute of Organic Chemistry, Chinese Academy of Sciences |
Assistant professor |
Research Interests
My research focuses on natural product biosynthesis and enzymatic mechanisms, with specialized expertise in:
1. Post-translational modifications of ribosomally synthesized and post-translationally modified peptides (RiPPs)
2. Biosynthetic logic of non-proteinogenic amino acids
Research Projects
1. 2025.01-2027.12, Genome mining and biosynthetic investigation of Streptomyces-derived lasso peptides. Young Scientists Fund of Natural Science Foundation of Shandong Province (Grant No. ZR2024QC035). Host
2. 2020.09-2025.08, The Future Plan for Young Scholars of Shandong University.
3. 2020.01-2022.12, The biosynthesis and enzymatic mechanism of polyyne natural products from bacteria. Young Scientists Fund of National Natural Science Foundation of China (Grant No. 21907057). Host
4. 2019.07-2022.06, The biosynthetic mechanism of cepacins. Young Scientists Fund of Natural Science Foundation of Jiangsu Province (Grant No. BK20190201). Host
5. 2019.03-2021.12, The biosynthesis and enzymatic mechanism of polyyne natural products from bacteria. The Fundamental Research Funds of Shandong University (Grant No. 2019GN032). Host
Representative Publications
1. Zhong G.; Chen M.; Liu W.* Structural diversity research of natural products based on biosynthetic mechanism. SCIENTIA SINICA Vitae 2017, 47, 482-495.
2. Zhong G.; Zhao Q.; Zhang Q.; Liu W.* 4-Alkyl-l-(dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage. Nat. Commun. 2017, 8, 16109.
3. Zhong G.; Chen H.; Liu, W.* Reply to ‘C-C bond cleavage in biosynthesis of 4-alkyl-l-proline precursors of lincomycin and anthramycin cannot precede C-methylation’. Nat. Commun. 2018, 9, 3168.
4. Zhong G.; Chen H.; Liu, W.* Recent advances in the biosynthesis of lincosamide antibiotics. Chinese Science Bulletin 2019, 64, 13-27.
5. Pang L.; Niu W.; Duan Y.; Huo L.; Li A.; Wu J.; Zhang Y.; Bian X.*; Zhong G.* In vitro characterization of a nitro-forming oxygenase involved in 3-(trans-2’-aminocyclopropyl) alanine biosynthesis. Eng. Microbiol. 2022, 2, (1), 100007.
6. Duan Y.; Niu W.; Pang L.; Bian X.; Zhang Y.; Zhong G.* Unusual post-translational modifications in the biosynthesis of lasso peptides. Int. J. Mol. Sci. 2022, 23, (13), 7231.
7. Zhong G.#; Wang Z.#; Yan F.; Zhang Y.; Huo L.* Recent advances in discovery, bioengineering and bioactivity-evaluation of ribosomally synthesized and post-translationally modified peptides. ACS Bio Med Chem Au 2023, 3, (1), 1-31. (ACS Editors’ Choice).
8. Pang L.; Niu W.; Duan Y.; Zhang Y.; Bian X.; Zhong G.* Characterization of GvgD and GvgH encoded in the biosynthetic gene cluster of 4-formylaminooxyvinylglycine. Org. Chem. Front. 2023, 10, (11), 2782-2789.
9. Duan Y.; Niu W.; Pang L.; Mu D.; Du Z.; Zhang Y.;* Bian X.;* Zhong G.* Leader peptide removal in lasso peptide biosynthesis based on penultimate isoleucine residue. Front. Microbiol. 2023, 14, 1181125.
10. Zhong G.* Cytochromes P450 associated with the biosyntheses of ribosomally-synthesized and post-translationally modified peptides. ACS Bio Med Chem Au 2023, 3, (5), 371-388.
11. Pang L.#; Yao D.#; Gao F.#; Bian X.; Zhang Y.; Zhong G.* Biosyntheses of azetidine-containing natural products. Org. Biomol. Chem. 2023, 21, (36), 7242-7254.
Honors and awards
1. 2023.08, as supervisor for China undergraduate life sciences contest (2023, scientific exploration) and received second prize at the provincial level.
2. 2023.12, as supervisor for Shandong biology competition for college students and received second prize at the provincial level.
Patents
1. Zhong G., Bian X., Zhang Y., Pang L. A novel method to synthesis (S)-6-nitronorleucine. Application number: CN202110932368.1, Authorization number: CN113817785B.
2.Zhong G., Bian X., Zhang Y., Duan Y. A protein heterologous expression vector pColdDuet-1 and its application. Application number: 202510732703.1
