Dayong Shi Professor PhD Supervisor Tel：13698682786 E-mail：shidayong@sdu.edu.cn

Education

09/2002-05/2005   PhD, Marine Pharmacology, Institute of Oceanology, Chinese Academy of Sciences

09/1999-07/2002   Master, Biochemical Engineering, Qingdao University of Science and Technology

09/1995-07/1999   Bachelor, Fermentation Engineering, Qilu University of Technology

Research Experience

01/2019-present     Professor, PhD Supervisor, Shandong University

01/2013-12/2018   Professor, PhD Supervisor, Institute of Oceanology, Chinese Academy of Sciences

08/2008-12/2012   Associate Professor, Institute of Oceanology, Chinese Academy of Sciences

10/2006-07/2008   Research assistant, Institute of Oceanology, Chinese Academy of Sciences

07/2005-09/2009   Post doctor, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute

Research Interests

1.Halogenated Marine drugs

2.Biological products

Research Projects

1.National Program for Support of Top-notch Young Professionals;

2.Taishan scholar Youth Project of Shandong province;

3.Shandong Provincial Natural Science Foundation for Distinguished Young Scholars (No.JQ201722);

4.Joint fund of Shandong Natural Science Foundation (No. ZR2021LSW013);

5.Qingdao Science and Technology Benefit People Demonstration Guide Special Project  (No.20-3-4-20-nsh);

6.Qingdao Marine Biomedical Science and Technology Innovation Center project (No.2017-CXZX01-1-1, No.2017-CXZX01-3-9);

7.Key research and development project of Shandong province (No.2016GSF115002, No.2016ZDJS07A13);

8.Strategic Biological Resources Service Network Program of Chinese Academy of Sciences (No. ZSTH-026);

9.Aoshan Talents Program Supported by Qingdao National Laboratory for Marine Science and Technology (No.2015ASTP);

10.Key Research Program of Frontier Sciences, CAS (No.QYZDB-SSW-DQC014);

11.National Natural Science Foundation of China (No.41276167);

12.Research and Development Program of Shinan District of Qingdao (No.2012-5-007-SW ，No. 2009-2-14-HY);

13.National science and technology support project (No.2013BAB01B02-2);

14.National Major Research Program of China (No. 2009ZX09103-148);

15.National High Technology Research 863 Program（NO.2007AA09Z410）

Representative Publications

1.Xiaolin Shi, Zemin Wang, Yuxiu Li, Xiaowei Li, Xiangqian Li, and Dayong Shi*,Palladium-Catalyzed Remote C-H Phosphonylation of Indoles at the C4 and C6 Positions by a Radical Approach, Angew. Chem. Int. Ed. 2021, 60, 13871-13876

2.Xiangqian Li, Xiaowei Li, Fang Liu, Shuo Li, and Dayong Shi*, Rational Multitargeted Drug Design Strategy from the Perspective of a Medicinal Chemist,        J. Med. Chem. 2021, 64, 15, 10581-10605

3.Jiao Luo, Meiling Zheng, Bo Jiang, Chao Li, Shuju Guo, Lijun Wang, Xiangqian Li, Rilei Yu, Dayong Shi*. Antidiabetic activity in vitro and in vivo of BDB, a    selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides. Br J Pharmacol. 2020; 177(19):4464-4480

4.Xiangqian Li, Qi Xu, Chao Li , Jiao Luo, Xiuxue Li , Lijun Wang , Bo Jiang，Dayong Shi  *.Toward a treatment of diabesity: In vitro and in vivo evaluation of    uncharged bromophenol derivatives as a new series of PTP1B inhibitors. European Journal of Medicinal Chemistry. 2019,166,178-185

5.Qi Xu, Ning Wu, Xiangqian Li, Chuanlong Guo, Chao Li, Bo Jiang, Huaizhi Wang and Dayong Shi*.Inhibition of PTP1B blocks pancreatic cancer progression    by targeting the PKM2/AMPK/mTOC1 pathway. Cell Death and Disease. 2019,10:874

6.Chuanlong Guo, Lijun Wang, Xiuxue Li, Shuaiyu Wang, Xuemin Yu, Kuo Xu, Yue Zhao, Jiao Luo, Xiangqian Li, Bo Jiang, and Dayong Shi*.Discovery of Novel Bromophenol-thiosemicarbazone hybrids as potent selective inhibitors of Poly(ADP-ribose) Polymerase‑1 (PARP-1) for use in cancer. Journal of Medicinal        Chemistry. 2019, 62, 3051-3067.

7.Jiao Luo, Qi Xu, Bo Jiang, Renshuai Zhang, Xiaoling Jia, Xiangqian Li, Lijun Wang, Chuanlong Guo, Ning Wu, Dayong Shi *. Selectivity,cell permeability and oral availability studies of novel bromophenol derivative HPN as protein tyrosine phosphatase 1B inhibitor, British Journal of Pharmacology, 2018, 175(1): 140-153.

8.Ning Li, Lijun Wang, Bo Jiang, Xiangqian Li, Shuju Guo, Dayong Shi *. Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the                treatment of type 2 diabetes mellitus. Eur J Med Chem, 2018, 151, 145-157.

9.Qi Xu, Jiao Luo, Ning Wu, Renshuai Zhang, Dayong Shi*.BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes. International Journal of Biological Macromolecules, 2018, 106: 379-386.

10.Xiangqian Li, Qi Xu, Jiao Luo, Lijun Wang, Bo Jiang, Renshuai Zhang, Dayong Shi*. Design, synthesis and biological evaluation of uncharged catechol              derivatives as selective inhibitors of PTP1B. Eur. J. Med. Chem., 2017; 136:348-359.

Honors and Awards

1.Foreign academician of Russian Academy of Natural Sciences (2022)

2.Top-notch Young Professional (2015)

3.Distinguished Youth of Shandong Provincial National Science Fund (2017)

4.Shandong Province Taishan Scholar Young Expert (2016)

5.Young and middle-aged experts with outstanding contributions in Shandong Province (2018)

6.Shandong Province Excellent Science and Technology Workers Proposal Special prize(2019)

7.Post expert in Shandong Province high-end talent pool (2016)

8.Shandong Youth Science and Technology Award (2015)

9.Aoshan Talents for Qingdao National Laboratory of Marine Science and Technology (2015)

10.Second Prize of Shandong Science and Technology Award (2014，2011)

11.Second Prize of Marine Innovation Achievement Award (2011)

12.Second Prize of Ocean Engineering Science and Technology Award (2018)

13.Second prize of Qingdao Science and Technology Award (2011)

14.Third prize of Ningbo Science and Technology Award (2018)

Patents

1.Dayong Shi; Xiangqian Li; Xin Wang; Jinbo Yang; Bromophenol-pyrazoline compounds, synthesis thereof and application thereof (2022-4-1, CN, ZL202010773200.6)

2.Dayong Shi; Xiangqian Li; Xin Wang; Jinbo Yang; Feng Xu; Rong Zhang; Use of Bromophenol-pyrazoline compounds in the treatment of porcine coronavirus    disease (2022-2-18, CN, ZL202011506016.1)

3.Dayong Shi; Yang Tian; Ruihua Liu; Xiangqian Li; Method for Synthesizing Silver(Ⅰ) Trifluoromethanethiolate (2021-8-31,CN, ZL202011200750.5)

4.Dayong Shi; Chuanlong Guo; Lijun Wang; Yue Zhao; Bo Jiang; Xiangqian Li; Application of a piperidine-bromophenol-indolone hybrid compound in antitumor drugs (2020-6-19, CN, ZL201710304762.4 )

5.Dayong Shi; Chuanlong Guo; Lijun Wang; Bo Jiang; Xiangqian Li; Application of trialdehyde resorcinol carbathiourea heterozygous compound in antitumor        drugs (2020-5-15, CN,ZL201810753795.1)

6.Dayong Shi; Lijun Wang; Chuanlong Guo; Xiangqian Li; Bo Jiang; Xiaowei Li; Preparation and application of six PARP1 inhibitors (2020-4-24,CN, ZL201810812259.4)

7.Dayong Shi; Xiangqian Li; Lijun Wang; Bo Jiang; Ning Wu; Alginic plant-based softgel capsule capsule shell and preparation method (2020-3-10, CN, ZL201611150751.7)

8.Dayong Shi; Xiangqian Li; Lijun Wang; Bo Jiang; Oxadiazole compounds and their use in the preparation of drugs for the prevention and / or treatment of type 2 diabetes mellitus (2019-7-26,CN, ZL201611175726.4)

9.Dayong Shi; Bo Jiang; Lijun Wang; Ning Wu; Shuaiyu Wang; Xiangqian Li; Meng Yang; Nine PTP1B inhibitors and their synthesis and application (2018-4-17, CN, ZL201510278442.7)

10.Dayong Shi; Shuju Guo; Xiao Fan; Weishen Lu; Yongchao Cui;PTP1B inhibitors, synthesis thereof and application thereof in preparation of medicaments for      treating type 2 diabetes mellitus(2014-8-26, US, US8816129 B2 )