Zheng Zhang Researcher, PhD supervisor/ Master supervisor

Tel：0532-58631557 E-mail： zhangzheng@sdu.edu.cn

Education

Degree	Date	Affiliation	Major
PhD	2014.09-2018.06	Shandong University	Microbiology
Bachelor	2003.09-2007.06	Shandong University	Biology

Research Experience

Date	Affiliation	Position
2021.01-present	State Key Lab of Microbial Technology, Shandong University	Researcher
2020.08-2021.01	State Key Lab of Microbial Technology, Shandong University	Associate researcher
2018.07-2020.07	State Key Lab of Microbial Technology, Shandong University	Postdoctor
2007.07-2014.08	State Key Lab of Microbial Technology, Shandong University	Research assistant

Research Interests

1. Research on the evolution mechanism of microorganisms based on bioinformatics big data.

2. Mining of the antimicrobial toxin-immunity protein systems.

3. Global distribution of prokaryotes functional genes.

Research Projects

1. The National Natural Science Foundation of China, 2023-2026

2. The Science & Technology Fundamental Resources Investigation Program, 2022-2025

3. Qilu Young Scholar Talent Start Funding, 2021-2025

4. The Natural Science Foundation of Jiangsu Province, 2019-2022

5. China Postdoctoral Science Foundation, 2018-2020

Representative Publications

1.Liu, Y., Liu, S., Pan, Z., Ren, Y., Jiang, Y., Wang, F., Li, D., Li, Y. Z.*, & Zhang, Z.* (2023). PAT: a comprehensive database of prokaryotic antimicrobial toxins. Nucleic Acids Research, 51(D1): D452-D459. (5 Year Impact Factor: 17.210)

2.Li, D., Zhang, Z.*, Wang, J., Zhang, P., Liu, Y. & Li, Y. Z.* (2023) Estimate of the degradation potentials of cellulose, xylan, and chitin across global prokaryotic communities. Environmental Microbiology, 25(2): 397-409. (5 Year Impact Factor: 6.820)

3.Ding, P., Ming, Z., Liu, J., Erill, I., & Zhang, Z.* (2022). Microbiome and microbial informatics. Frontiers in Microbiology, 4278. (5 Year Impact Factor: 6.843)

4.Zhang, P., Zhang, L., Jiang, X., Diao, X. T., Li, S., Li, D. D., Zhang, Z., Fang, J., Tang Y. J., Wu, D. L., Wu, C., & Li, Y. Z. (2022). Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B. Communications Biology, 5(1): 1-11. (5 Year Impact Factor: 6.816)

5.Zhang, Z.¹*, Liu, Y.¹, Zhang, P., Wang, J., Li, D., & Li, Y. Z.* (2021). PAAR proteins are versatile clips that enrich the antimicrobial weapon arsenals of prokaryotes. mSystems, 6(6): e00953-21. (5 Year Impact Factor: 9.039)

6.Li, D. D., Wang, J. L., Liu, Y., Li, Y. Z.*, & Zhang, Z.* (2021). Expanded analyses of the functional correlations within structural classifications of glycoside hydrolases. Computational and Structural Biotechnology Journal, 19: 5931. (5 Year Impact Factor: 6.836)

7.Feng, Z.¹, Zhang, Z. ¹, Liu, Y., Gu, J., Cheng, Y., Hu, W., Li, Y. Z., & Han, W.* (2021). The second chromosome promotes the adaptation of the genus Flammeovirga to complex environments. Microbiology Spectrum, 9(3): e00980-21. (5 Year Impact Factor: 8.113)

8.Wang, J.¹, Wang, J.¹, Wu, S., Zhang, Z.*, & Li, Y. Z.* (2021). Global geographic diversity and distribution of the myxobacteria. Microbiology Spectrum, 9(1): e00012-21. (5 Year Impact Factor: 8.113)

9.Pan, Z., Zhang, Z., Zhuo, L., Wan, T., & Li, Y. Z.* (2021). Bioinformatic and functional characterization of Hsp70s in Myxococcus xanthus. mSphere, 6(3): e00305-21. (5 Year Impact Factor: 5.492)

10.Liu, Y., Wang, J., Zhang, Z., Wang, F., & Li, Y. Z.* (2021). Two PAAR proteins with different C-terminal extended domains have distinct ecological functions in Myxococcus xanthus. Applied and Environmental Microbiology, 87(9): e00080-21. (5 Year Impact Factor: 5.632)

11.Zhang, Z.¹*, Wang, J.¹, Wang, J., Wang, J., & Li, Y. Z.* (2020). Estimate of the sequenced proportion of the global prokaryotic genome. Microbiome, 8(1): 1-9. (5 Year Impact Factor: 19.813)

12.Liu, Y., Zhang, Z.*, Wang, F., Li, D. D., & Li, Y. Z.* (2020). Identification of type VI secretion system toxic effectors using adaptors as markers. Computational and Structural Biotechnology Journal, 18: 3723-3733. (5 Year Impact Factor: 6.836)

13.Zhang, P.¹, Zhang, Z.¹, Zhang, L., Wang, J., & Wu, C.* (2020). Glycosyltransferase GT1 family: Phylogenetic distribution, substrates coverage, and representative structural   features. Computational and Structural Biotechnology Journal, 18: 1383-1390. (5 Year Impact Factor: 6.836)

14.Wang, J., Wang, J., Zhang, Z., Li, Z., Zhang, Z., Zhao, D., ... & Li, Y. Z.* (2020). Shifts in the bacterial population and ecosystem functions in response to vegetation in the    Yellow River delta wetlands. mSystems, 5(3). (5 Year Impact Factor: 9.039)

15.Chen, X. J., Zhang, Z., Li, Y. J., Zhuo, L., Sheng, D. H., & Li, Y. Z.* (2020). Insights into the persistence and phenotypic effects of the endogenous and cryptic plasmid pMF1 in its host strain Myxococcus fulvus 124B02. FEMS Microbiology Ecology, 96(3): fiaa001. (5 Year Impact Factor: 5.780)

16.Li, D., Wang, J., Jin, Z., & Zhang, Z.* (2019). Structural and evolutionary characteristics of dynamin-related GTPase OPA1. PeerJ, 7: e7285. (5 Year Impact Factor: 3.369)

17.Zhang, P., Zhang, Z., Li, Z. F., Chen, Q., Li, Y. Y., Gong, Y., ... & Li, Y. Z.* (2019). Phylogeny‐guided characterization of glycosyltransferases for epothilone glycosylation.   Microbial Biotechnology, 12(4): 763-774. (5 Year Impact Factor: 7.412)

18.Zhang, Z., Wang, J., Gong, Y., & Li, Y. Z.* (2018). Contributions of substitutions and indels to the structural variations in ancient protein superfamilies. BMC Genomics, 19(1): 1-9. (5 Year Impact Factor: 4.930)

19.Gong, Y.¹, Zhang, Z.¹, Liu, Y., Zhou, X. W., Anwar, M. N., Li, Z. S., ... & Li, Y. Z.* (2018). A nuclease‐toxin and immunity system for kin discrimination in Myxococcus xanthus. Environmental Microbiology, 20(7): 2552-2567. (5 Year Impact Factor: 6.820)

20.Zhuo, L., Zhang, Z., Pan, Z., Sheng, D. H., Hu, W., & Li, Y. Z.* (2018). CIRCE element evolved for the coordinated transcriptional regulation of bacterial duplicate groELs. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1861(10): 928-937. (5 Year Impact Factor: 5.214)

21.Li, Y. J., Liu, Y., Zhang, Z., Chen, X. J., Gong, Y., & Li, Y. Z.* (2018). A post-segregational killing mechanism for maintaining plasmid pMF1 in its Myxococcus fulvus host. Frontiers in Cellular and Infection Microbiology, 8: 274. (5 Year Impact Factor: 6.340)

22.Gong, Y., Zhang, Z., Zhou, X. W., Anwar, M. N., Hu, X. Z., Li, Z. S., ... & Li, Y. Z.* (2018). Competitive interactions between incompatible mutants of the social bacterium Myxococcus xanthus DK1622. Frontiers in Microbiology, 9: 1200. (5 Year Impact Factor: 6.843)

23.Yue, X. J.¹, Cui, X. W.¹, Zhang, Z., Hu, W. F., Li, Z. F., Zhang, Y. M., & Li, Y. Z.* (2018). Effects of transcriptional mode on promoter substitution and tandem engineering for the production of epothilones in Myxococcus xanthus. Applied Microbiology and Biotechnology, 102(13): 5599-5610. (5 Year Impact Factor: 5.365)

24.Gao, X.*, Zhang, Z.*, Li, Y., Zhu, H., Wang, S., & Li, C. (2017). A newly determined member of the meso-diaminopimelate dehydrogenase family with a broad substrate spectrum. Applied and Environmental Microbiology, 83(11). (5 Year Impact Factor: 5.632)

25.Liu, L., Zhang, Z.*, Shao, C. L., & Wang, C. Y.* (2017). Analysis of the sequences, structures, and functions of product-releasing enzyme domains in fungal polyketide synthases. Frontiers in Microbiology, 8: 1685. (5 Year Impact Factor: 6.843)

26.Yue, X. J., Cui, X. W., Zhang, Z., Peng, R., Zhang, P., Li, Z. F., & Li, Y. Z.* (2017). A bacterial negative transcription regulator binding on an inverted repeat in the promoter  for epothilone biosynthesis. Microbial Cell Factories, 16(1): 1-12. (5 Year Impact Factor: 6.496)

27.Zhuo, L.¹, Wang, Y.¹, Zhang, Z., Li, J., Zhang, X. H., & Li, Y. Z.* (2017). Myxococcus xanthus DK1622 coordinates expressions of the duplicate groEL and single groES genes for synergistic functions of groELs and groES. Frontiers in Microbiology, 8: 733. (5 Year Impact Factor: 6.843)

28.Peng, R., Chen, J. H., Feng, W. W., Zhang, Z., Yin, J., Li, Z. S., & Li, Y. Z.* (2017). Error-prone DnaE2 balances the genome mutation rates in Myxococcus xanthus DK1622. Frontiers in Microbiology, 8: 122. (5 Year Impact Factor: 6.843)

29.Wang, J., Zhang, Z.*, Chang, F., & Yin, D.* (2016). Bioinformatics analysis of the structural and evolutionary characteristics for toll-like receptor 15. PeerJ, 4: e2079. (5 Year Impact Factor: 3.369)

30.Wang, J.¹, Zhang, Z.¹*, Liu, J., Zhao, J., & Yin, D.* (2016). Ectodomain architecture affects sequence and functional evolution of vertebrate toll-like receptors. Scientific Reports, 6(1): 1-10. (5 Year Impact Factor: 5.516)

31.Liu, L., Zhang, Z.*, Shao, C. L., Wang, J. L., Bai, H., & Wang, C. Y.* (2015). Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains. Scientific Reports, 5(1): 1-12. (5 Year Impact Factor: 5.516)

32.Wang, J.¹, Zhang, Z.¹*, Fu, H., Zhang, S., Liu, J., Chang, F., ... & Yin, D.* (2015). Structural and evolutionary characteristics of fish-specific TLR19. Fish & Shellfish Immunology, 47(1): 271-279. (5 Year Impact Factor: 4.799)

33.Wang, J., Zhang, Z.*, Liu, J., Li, F., Chang, F., Fu, H., ... & Yin, D.* (2015). Structural characterization and evolutionary analysis of fish-specific TLR27. Fish & Shellfish Immunology, 45(2): 940-945. (5 Year Impact Factor: 4.799)

34.Wang, Y.¹, Zhang, W. Y.¹, Zhang, Z., Li, J., Li, Z. F., Tan, Z. G., ... & Li, Y. Z.* (2013). Mechanisms involved in the functional divergence of duplicated GroEL chaperonins    in Myxococcus xanthus DK1622. PLoS Genet, 9(2): e1003306. (5 Year Impact Factor: 6.514)

35.Zhang, Z.¹, Xing, C.¹, Wang, L., Gong, B.*, & Liu, H. (2012). IndelFR: a database of indels in protein structures and their flanking regions. Nucleic Acids Research, 40(D1): D512-D518. (5 Year Impact Factor: 17.210)

36.Zhang, Z., Huang, J., Wang, Z., Wang, L.*, & Gao, P. (2011). Impact of indels on the flanking regions in structural domains. Molecular Biology and Evolution, 28(1): 291-301. (5 Year Impact Factor: 20.074)

37.Zhang, Z., Wang, Y., Wang, L.*, & Gao, P.* (2010). The combined effects of amino acid substitutions and indels on the evolution of structure within protein families. PLoS    One, 5(12): e14316. (5 Year Impact Factor: 4.069