Yuezhong Li Professor PhD Supervisor & Master Supervisor

Tel: 0532-58631539  E-mail：lilab@sdu.edu.cn

Education

Degree	Date	Affiliation	Major
PhD	1993	Shandong University	Microbiology
Master	1990	Shandong Agriculture University	Mycology
Bachelor	1987	Shandong University	Microbiology

Research Experience

Date	Affiliation	Position
1999-present	Shandong University	Professor
1995-1999	Shandong University	Associate Professor
1996	Gesellschaft für Biotechnologische Forschung (GBF)	Senior Visiting Scholar
1993-1995	Microbial Engineering, Institute of Applied Ecology,Chinese Academy of Science	Post-doctoral

Research Interests

1. Resources and diversity of myxobacteria, including cultured and uncultured myxobacteria taxa;

2. Cell behavior and evolution study based on the myxobacteria resources;

3. Fermentation engineering and metabolic engineering research, taking the antitumor compounds Epothilones as the main object;

4. To establish and improve genetic manipulation systems in myxobacteria, and to perform genetic analysis and modification.

Representative Publications (recent 5 years)

Tian-yu Wan, Li Zhuo*, Zhuo Pan, Rui-yun Chen, Han Ma, Ying Cao, Jianing Wang, Jing-jing Wang, Wei-feng Hu, Ya-jun Lai, Muhammad Hayat, Yue-zhong Li*. Dosage constraint of the ribosome-associated molecular chaperone drives the evolution and fates of its duplicates in bacteria. mBio. 2024. accepted.

Tian-yu Wan, Ying Cao, Ya-jun Lai, Zhuo Pan, Yue-zhong Li*, Li Zhuo*. Functional investigation of the two ClpPs and three ClpXs in Myxococcus xanthus DK1622. mSphere. 2024. e00363-24.

Hu W, Yang J, Wang J, Yuan S, Yue X, Zhang Z, Zhang Y, Meng J, Li Y*. Characteristics and immune functions of the endogenous CRISPR-Cas systems in myxobacteria. mSystems. 2024. 9: e01210-23.

Yue, X. J.*, Wang, J. R., Zhao, J. N., Pan, Z., Li, Y. Z.*. Determination of the chromosomal position effects for plug-and-play application in the Myxococcus xanthus chassis cells. Synthetic and Systems Biotechnology. 2024. 9(3), 540-548.

Li, D. D.#, Wang, J.#, Jiang, Y., Zhang, P., Liu, Y., Li, Y. Z.*, Zhang, Z.*. Quantifying functional redundancy in polysaccharide-degrading prokaryotic communities. Microbiome. 2024. 12(1), 120.

Wang, C. Y., Hu, J. Q., Wang, D. G., Li, Y. Z.*, Wu, C*. Recent advances in discovery and biosynthesis of natural products from myxobacteria: an overview from 2017 to 2023. Natural Product Reports. 2024. 41(6), 905–934.

Zhu, L. L.#, Yang, Q.#, Wang, D. G.#, Niu, L., Pan, Z., Li, S., Li, Y. Z.*, Zhang, W.*, Wu, C.*. Deciphering the Biosynthesis and Physiological Function of 5-Methylated Pyrazinones Produced by Myxobacteria. ACS Central Science. 2024. 10(3), 555-568.

Pan, Z.#, Li, D. D.#, Li, P., Geng, Y., Jiang, Y., Liu, Y., Li, Y. Z.*, Zhang, Z*. GDPF: a data resource for the distribution of prokaryotic protein families across the global biosphere. Nucleic Acids Research. 2024. 52(D1), D724-D731.

Pan, Z., Zhuo, L., Wan, T. Y., Chen, R. Y., Li, Y. Z.*. DnaK duplication and specialization in bacteria correlates with increased proteome complexity. mSystems. 2024. 9(4): e0115423.

Ran, Q., Du, X., Han, L., Wang, J.*, Li, Y. Z*. Three novel species of the genus Flavobacterium, Flavobacterium odoriferum sp. nov., Flavobacterium fragile sp. nov. and Flavobacterium luminosum sp. nov., isolated from activated sludge. International Journal of Systematic and Evolutionary Microbiology. 2024. 74(2), 10.1099/ijsem.0.006258.

Yuan, S. F., Yue, X. J.*, Hu, W. F., Wang, Y., Li, Y. Z.*. Genome-wide analysis of lipolytic enzymes and characterization of a high-tolerant carboxylesterase from Sorangium cellulosum. Frontiers in Microbiology. 2023. 14, 1304233.

Xinjing Yue*, Duohong Sheng, Li Zhuo, Yue-zhong Li*. Genetic manipulation and tools in myxobacteria for the exploitation of secondary metabolism. Engineering Microbiology. 2023, 3, 100075.

Jianing Wang*, Zhuo Pan, Jianshui Yu, Zheng Zhang, Yue-zhong Li*. Global assembly of microbial communities. mSystems. 2023, 8: e01289-22.

Degao Wang#, Chaoyi Wang#, Jiaqi Hu#, Jingjing Wang#, Wenchao Liu, Wenjuan Zhang, Xinran Du, Han Wang,Lele Zhu, Haiyan Sui, Yue-zhong Li*, Changsheng Wu*. Constructing a Myxobacterial Natural Product Database to Facilitate NMR-Based Metabolomics Bioprospecting of Myxobacteria. Analytical chemistry. 2023, 95, 5256-5266.

Dan-Dan Li, Zheng Zhang*, Jia-Ning Wang, Peng Zhang, Ya Liu, Yue-Zhong Li*. Estimate of the degradation potentials of cellulose, xylan, and chitin across global prokaryotic communities. Environmental Microbiology. 2022 Nov 29.

Ya Liu, Sheng Liu, Zhuo Pan, Yu Ren, Yiru Jiang, Feng Wang, Dan-Dan Li, Yue-Zhong Li*, Zheng Zhang*. PAT: a comprehensive database of prokaryotic antimicrobial toxins. Nucleic Acids Research. 2022 Oct 16: gkac879.

Xinran Du, Qi Ran, Jianing Wang, Hong Jiang, Jingjing Wang*, Yue-Zhong Li*. Microvirga roseola sp. nov. and Microvirga lenta sp. nov., isolated from Taklamakan Desert soil. International Journal of Systematic and Evolutionary Microbiology. 2022 Jun;72(6).

Li Zhuo, Tian-Yu Wan, Zhuo Pan, Jia-Ning Wang, Duo-Hong Sheng, Yue-Zhong Li*. A Dual-Functional Orphan Response Regulator Negatively Controls the Differential Transcription of Duplicate groELs and Plays a Global Regulatory Role in Myxococcus. mSystems. 2022 Apr 26; 7(2): e0105621.

Shuge Wu, Jingjing Wang*, Jianing Wang, Xinran Du, Qi Ran, Qi Chen, Duohong Sheng, Yue-Zhong Li*. Halalkalibacterium roseum gen. nov., sp. nov., a new member of the family Balneolaceae isolated from soil. International Journal of Systematic and Evolutionary Microbiology. 2022 Apr; 72(4).

Changsheng Wu*,#, Yinzhen Yin#, Le-Le Zhu, Youming Zhang, Yue-Zhong Li*. Metagenomic Sequencing Driven Multidisciplinary Approaches to Shed Light on The Untapped Microbial Natural Products. Drug Discovery Today 2022 Mar; 27(3): 730-742.

Li-Juan Zhang, De-Gao Wang, Peng Zhang, Changsheng Wu*, Yue-Zhong Li*. Promiscuity Characteristics of Versatile Plant Glycosyltransferases for Natural Product Glycodiversification. ACS Synthetic Biology. 2022 Feb 18; 11(2): 812-819.

Peng Zhang, Lijuan Zhang, Xukai Jiang, Xiao-Tong Diao, Shuang Li, Dan-Dan Li, Zheng Zhang, Junqiang Fang, Ya-Jie Tang, Da-Lei Wu, Changsheng Wu*, Yue-Zhong Li*. Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B. Communications Biology. 2022 Jan 27; 5(1): 100.

Zheng Zhang#,*, Ya Liu#, Peng Zhang, Jianing Wang, Dandan Li, Yue-zhong Li*. PAAR proteins are versatile clips that enrich the antimicrobial weapon arsenals of prokaryotes. mSystems 2021 Dec 21; 6(6): e0095321.

Dan-dan Li, Jin-lan Wang, Ya Liu, Yue-zhong Li*, Zheng Zhang*. Expanded analyses of the functional correlations within structural classifications of glycoside hydrolases. Computational and Structural Biotechnology Journal 2021 Nov 2; 19: 5931-5942.

Wei-Feng Hu#, Luo Niu#, Xin-jing Yue, Le-Le Zhu, Wei Hu, Yue-Zhong Li*, Changsheng Wu*. Characterization of Constitutive Promoters for The Elicitation of Secondary Metabolites in Myxobacteria. ACS Synthetic Biology 2021, 10, 2904−2909.

De-Gao Wang#, Luo Niu#, Zhao-Min Lin, Jing-Jing Wang, Dong-Fang Gao, Hai-Yan Sui, Yue-Zhong Li*, Changsheng Wu*. The Discovery and Biosynthesis of Nicotinic Myxochelins from an Archangium sp. SDU34. Journal of Natural Products 2021, 84, 2744−2748.

Ye Wang, Xin-jing Yue*, Shu-fei Yuan, Yu Hong, Wei-feng Hu, Yue-zhong Li*. Internal promoters and their effects on the transcription of operon genes for the epothilone production in Myxococcus xanthus. Frontiers in Bioengineering and Biotechnology 2021 Oct 27;9. doi: 10.3389/fbioe.2021.758561

Jingjing Wang, Qi ran, Xinran Du, Shuge Wu, Jianing Wang, Duohong Sheng, Qi Chen, Zongjun Du, Yue-zhong Li*. Two new Polyangium species, P. aurulentum sp. nov. and P. jinanense sp. nov., isolated from a soil sample. Systematic and Applied Microbiology 2021, 44, 126274.

Duohong Sheng#, Xiaojing Chen#, Yajie Li, Jingjing Wang, Li Zhuo, Yue-zhong Li*. ParC, a new partitioning protein, is necessary for the active form of ParA from Myxococcus pMF1 plasmid. Frontiers in Microbiology 2021, 11:623699.

Yuelan Li#, Li Zhuo#, Xiaobin Li, Yongqiang Zhu, Shuge Wu, Wei Hu, Tao Shen, Yue-Zhong Li*, changsheng Wu*. Myxadazoles, myxobacterium-derived isoxazole-benzimidazole hybrids with cardiovascular activities. Angewandte Chemie International Edition 2021, 60, 21679 –21684.

Jingjing Wang#, Jianing Wang#, Shuge Wu, Zheng Zhang*, Yue-zhong Li*. Global geographic diversity and distribution of the myxobacteria. Microbiology Spectrum 2021, 9: e00012-21.

Jianing Wang, Lidong Wang, Weifeng Hu, Zhuo Pan, Peng Zhang, Chuandong Wang, Jingjing Wang, Shuge Wu, Yue-zhong Li*. Assembly processes and source tracking of planktonic and benthic bacterial communities in the Yellow River estuary. Environmental Microbiology 2021, 23(5), 2578–2591.

Jia-Qi Hu#, Jing-Jing Wang#, Yue-Lan Li, Li Zhuo, Ai Zhang, Hai-Yan Sui, Xiao-Ju Li, Tao Shen, Yizhen Yin, Zhi-Hong Wu, Wei Hu, Yue-Zhong Li*, Changsheng Wu*. Combine NMR-basedmetabolic profiling andgenome mining for the accelerated discovery of archangiumide, an allenic macrolide from the myxobacteriumArchangium violaceum SDU8. Organic Letters 2021, 23, 2114−2119.

Ya Liu, Jianing Wang, Zheng Zhang, Feng Wang, Ya Gong, Duo-hong Sheng, Yue-zhong Li*. Two PAAR proteins with different C-terminal extended domains have distinct ecological functions in Myxococcus xanthus. Applied and Environmental Microbiology 2021, 87: e00080-21.

Duohong Sheng*, Ye Wang, Zhiwei Jiang, Dongkai Liu, Yuezhong Li*. ImuA facilitates SOS mutagenesis by inhibiting RecA-mediated activity in Myxococcus xanthus. Applied and Environmental Microbiology 2021, doi:10.1128/AEM.00919-21.

Zhuo Pan, Zheng Zhang, Li Zhuo, Tian-yu Wan, Yue-zhong Li*. Bioinformatic and functional characterization of Hsp70s in Myxococcus xanthus. mSphere 2021, 6: e00305-21.

Duo-hong Sheng#*, Ye Wang#, Shu-ge Wu, Rui-xin Duan, Yue-zhong Li*. The regulation of LexA on UV induced SOS response in Myxococcus xanthus based on transcriptome analysis. Journal of Microbiology and Biotechnology, 2021, 31(6).

Zheng Zhang#*, Jianing Wang#, Jinlan Wang, Jingjing Wang, Yuezhong Li*. Estimate of the sequenced proportion of the global prokaryotic genome. Microbiome. 2020 Sep 16;8(1):134.

Wang, J. N., Wang, J. J., Zhang, Z., Li, Z., Li, Y. Z*. Shifts in the Bacterial Population and Ecosystem Functions in Response to Vegetation in the Yellow River Delta Wetlands. mSystems, 2020, 5(3): e00412-20

Y Liu, Z Zhang, F Wang, DD Li, YZ Li*. Identification of type VI secretion system toxic effectors using adaptors as markers. Computational and Structural Biotechnology Journal, 2020, 18(6):3723-3733.

DH Sheng, YX Wang, M Qiu, JY Zhao, YZ Li*. Functional Division Between the RecA1 and RecA2 Proteins in Myxococcus xanthus. Frontiers in Microbiology, 2020, 11:140.

XJ Chen, Z Zhang, YJ Li, L Zhuo, DH Sheng, YZ Li*. Insights into the persistence and phenotypic effects of the endogenous and cryptic plasmid pMF1 in its host strain Myxococcus fulvus 124B02. FEMS Microbiology Ecology, 2020(3):3.

Peng Zhang, Lijuan Zhang, Xin-jing Yue, Ya-jie Tang, Changsheng Wu*, Yue-zhong Li*. Effects of glycosylation on the bioactivity of rapamycin. Applied Microbiology and Biotechnology, 2020, 104(21):9125–9134

SG Wu, JJ Wang, JN Wang, Q Chen, YZ Li*. Psychroflexus aurantiacus sp. nov. isolated from soil in the Yellow River Delta wetlands. International Journal of Systematic and Evolutionary Microbiology, 2020, 70(12).

SG Wu, JJ Wang, JN Wang, Q Chen, YZ Li*. Paucihalobacter ruber gen. nov. sp. nov. isolated from a haloalkaline lake sediment sample. International Journal of Systematic and Evolutionary Microbiology, 2020, 70(10).

JJ Wang, SG Wu, Q Chen, DH Sheng, YZ Li*. Deinococcus terrestris sp. nov. a gamma ray- and ultraviolet-resistant bacterium isolated from soil. International Journal of Systematic and Evolutionary Microbiology, 2020, 70(9).

Peng Zhang, Zheng Zhang, Zhi-feng Li, Qi Chen, Yao-yao Li, Ya Gong, Xin-jing Yue, Duo-hong Sheng, You-ming Zhang, Changsheng Wu*, Yue-zhong Li*. Phylogeny-guided characterization of glycosyltransferases for epothilone glycosylation. Microbial Biotechnology, 2019, 12(4), 763-774

Mian Nabeel Anwar, Zhi Feng Li, Gong Ya, Raghvendra Partap Singh, Yue-zhong Li*. Omics studies revealed the factors involved in the formation of colony boundary in Myxococcus xanthus. Cells, 2019, 8, 530.

Honors and Awards

1.Science and Technology Award of Shandong Province (Natural Science), second prize, 2021

2.Natural Science Award, Chinese Ministry of Education, first prize, 2016.

3.Talents Project national candidate, 2009.

4.National Distinguished Young Scholar, 2008.

5.Invention award, Shandong Province, second prize, 2006.

6.Government Subsidy Specialist, 2006.

7.New Century Excellent Talent, Chinese Minister of Education, 2004.

8.Excellent Skeleton Teacher, Chinese Minister of Education, 2002.

Patents

1.エポチロングリコシド類化合物とそれを活性成分とする配合物及びその応用.Inventors: Yue-zhong Li, Yue-mao Shen, Lin Zhao, Chun-hua Lu. Japanese patent:5462268. Application date: 2008-11-28. Authorization date: 2014-01-24.

2.Epothilone glycoside compound, compositions containing epothilone glycoside compound as active components and uses thereof. Inventors: Yue-zhong Li, Yue-mao Shen, Lin Zhao, Chun-hua Lu. European patent:EP2332950B1，Application date: 2008-06-10. Authorization date: 2011-06-15.