Education

Degree	Date	Affiliation	Major
PhD	2000.9-2005.6	Shandong University	Microbiology
Bachelor	1996.9-2000.6	Shandong University	Microbiology

Research Experience

Date	Affiliation	Position
2015.9-	Shandong University	Associate Professor
2009.6-2015.8	Shandong University	Lecturer
2009.9-2010.8	Chalmers University of Technology, Sweden	Postdoc
2006.7-2009.5	Henan Tianguan Group Co., Ltd.	Postdoc
2005.7-2006.6	Jiangnan University	Lecturer

Research Interests

1. Metabolic Engineering

2. Regulation of Carbon Metabolism inSaccharomyces cerevisiae

3. NutritionalControl of Growth and Development in Yeast

4. The Stress Response and Tolerance Mechanism of Yeast to Toxic Substance

Research Projects

1. Optimizing the ethanol fermentation performance of C5C6 co-utilizing yeast. The National Key Research and Development Program of China (Sub-topic), 2018YFB1501702-4，2019.1-2022.12，PI

2. Study on the role of protein acetylation in carbon metabolism regulation of Saccharomyces cerevisiae. The National Natural Science Foundation of China，31770046，2018.1-2021.12，PI

3. Construction and optimization of yeast cell factory for tyrosol production. The Major Program of Shandong Province Natural Science Foundation， ZR2018ZB0209，2018.6-2020.12，PI

4. Study of the xylose metabolic efficiency decisive factors relate on the glucose sensing network and glucose metabolism subsequent effect. The National Natural Science Foundation of China， 31470166，2015.1-2018.12，PI

5. Construction ofhigh efficient cellulase and xylitol production strain. The National High Technology Research and Development Program of China (863) (Sub-topic)， 2014AA021903，2014.1-2016.12，PI

6.Contructing industrialSaccharomyces cerevisiae with high stress tolerance and xylose utilizing capacity and modification its fermentationprocess. The Open subject ofState Key Laboratory of Motor Vehicle Biofuel Technology， 2014.7-2016.6，PI

7. Study on the effect of key metabolic enzymes to the xylose-utilizing yeast. The National Natural Science Foundation of China， 30970091，2010.1-2012.12，PI

8. Research and demonstration key technology for 10,000-ton level cellulose ethanol production. Research and demonstration of key technologies for 10,000 tons of cellulosic ethanol production.The Project of National Energy Administration of China，NY20130402，2013.1-2015.12，Cooperator

9. Study on the adaptability of the protein-host matching molecular mechanism for high xylose isomerase activity and effective xylose. The National Natural Science Foundation of China，31270151， 2012.01-2016.12，Cooperator

10. Integration of the technologies for the second generation bioethanol production.The International S&T Cooperation Program of China， 2010DFA32560，2010.01-2012.12，Cooperator

11. 酿酒酵母耐木质纤维素预处理原料毒性的机理研究Study on mechanism ofSaccharomyces cerevisiae resistant to lignocellulosic hydrolysate. The Independent Innovation Foundation of Shandong University, IIFSDU2010TS059， 2010.6-2012.12，PI

Representative Publications

1. Wei S, Liu Y, Wu M, Ma T, Bai X, Hou J, Shen Y*, Bao X.(2018). Disruption of the transcription factors Thi2p and Nrm1p alleviates the post-glucose effect on xylose utilization inSaccharomyces cerevisiae. Biotechnol Biofuels. 11:112. doi: 10.1186/s13068-018-1112-1. (IF 5.203)

2. Wang, X., Liang, Z., Hou, J., Shen, Y.*, & Bao, X.* (2017). The Absence of the Transcription Factor Yrr1p, Identified from Comparative Genome Profiling, Increased Vanillin Tolerance Due to Enhancements of ABC Transporters Expressing, rRNA Processing and Ribosome Biogenesis inSaccharomyces cerevisiae. Front Microbiol, 8, 367. doi: 10.3389/fmicb.2017.00367 (IF 4.165)

3. Hou, J.¹, Shen, Y.¹, Jiao, C., Ge, R., Zhang, X., & Bao, X.*. (2016). Characterization and evolution of xylose isomerase screened from the bovine rumen metagenome inSaccharomyces cerevisiae. J Biosci Bioeng, 121(2), 160-165. doi: 10.1016/j.jbiosc.2015.05.014 (IF 1.964)

4. Li, H.¹, Shen, Y.¹, Wu, M., Hou, J., Jiao, C., Li, Z., . . . Bao, X.*. (2016). Engineering a wild-type diploidSaccharomyces cerevisiae strain for second-generation bioethanol production. Bioresour Bioprocess, 3(1), 51. doi: 10.1186/s40643-016-0126-4 (新刊，虚拟IF 1.7)

5. Wang, X., Liang, Z., Hou, J., Bao, X.*, & Shen, Y.*. (2016). Identification and functional evaluation of the reductases and dehydrogenases fromSaccharomyces cerevisiae involved in vanillin resistance. BMC Biotechnol, 16(1), 31. doi: 10.1186/s12896-016-0264-y (IF 2.452)

6. Li, H., Wu, M., Xu, L., Hou, J., Guo, T., Bao, X., & Shen, Y.*. (2015). Evaluation of industrialSaccharomyces cerevisiae strains as the chassis cell for second-generation bioethanol production. Microb Biotechnol, 8(2), 266-274. doi: 10.1111/1751-7915.12245 (IF 3.991)

7. Wang, C., Bao, X., Li, Y., Jiao, C., Hou, J., Zhang, Q., . . . Shen, Y.*. (2015a). Cloning and characterization of heterologous transporters inSaccharomyces cerevisiae and identification of important amino acids for xylose utilization. Metab Eng, 30, 79-88. doi: 10.1016/j.ymben.2015.04.007 (IF 8.201)

8. Wang, C., Bao, X., Li, Y., Jiao, C., Hou, J., Zhang, Q., . . . Shen, Y.*. (2015b). Data set for cloning and characterization of heterologous transporters inSaccharomyces cerevisiae and identification of important amino acids for xylose utilization. Data Brief, 4, 119-126. doi: 10.1016/j.dib.2015.05.005

9. Shen, Y., Li, H., Wang, X., Zhang, X., Hou, J., Wang, L., . . . Bao, X*. (2014). High vanillin tolerance of an evolvedSaccharomyces cerevisiae strain owing to its enhanced vanillin reduction and antioxidative capacity. J Ind Microbiol Biotechnol, 41(11), 1637-1645. doi: 10.1007/s10295-014-1515-3 (IF 2.81)

10. Xu, L.¹, Shen, Y.¹ , Hou, J. , Tang, H., Wang, C., & Bao, X*. (2014). Promotion of extracellular activity of cellobiohydrolase I fromTrichoderma reesei by protein glycosylation engineering inSaccharomyces cerevisiae. Curr Synthetic Sys Biol 2(2), 1-6. doi: 10.4172/2332-0737.1000111

11. Wu Ho., Wu X., Zhao J., Bao X., Hou J., Wang L., Gao N, Shen Y*. (2014). Role and mechanism of protein quality control system in enhancing the thermotolerance ofSaccharomyces cerevisiae. Bioproces, 4, 7. (in Chinese)

12. Shen, Y., Hou, J., & Bao, X*. (2013). Enhanced xylose fermentation capacity related to an altered glucose sensing and repression network in a recombinantSaccharomyces cerevisiae. Bioengineered, 4(6), 435-437. doi: 10.4161/bioe.25542 (IF 1.87)

13. Wang, C.¹, Shen, Y.¹, Hou, J., Suo, F., & Bao, X*. (2013). An assay for functional xylose transporters inSaccharomyces cerevisiae. Anal Biochem, 442(2), 241-248. doi: 10.1016/j.ab.2013.07.041 (IF 2.243)

14. Peng, B.¹, Shen, Y.¹, Li, X., Chen, X., Hou, J., & Bao, X*. (2012). Improvement of xylose fermentation in respiratory-deficient xylose-fermentingSaccharomyces cerevisiae. Metab Eng, 14(1), 9-18. doi: 10.1016/j.ymben.2011.12.001 (IF 8.201)

15. Shen, Y.¹, Chen, X.¹, Peng, B., Chen, L., Hou, J., & Bao, X*. (2012). An efficient xylose-fermenting recombinantSaccharomyces cerevisiae strain obtained through adaptive evolution and its global transcription profile. Appl Microbiol Biotechnol, 96(4), 1079-1091. doi: 10.1007/s00253-012-4418-0 (IF 3.42)

16. Ji, L.¹, Shen, Y.¹, Xu, L., Peng, B., Xiao, Y., & Bao, X*. (2011). Enhanced resistance ofSaccharomyces cerevisiae to vanillin by expression of lacA from Trametes sp. AH28-2. Bioresour Technol, 102(17), 8105-8109. doi: 10.1016/j.biortech.2011.06.057 (IF 5.651)

17. Peng, B., Chen, X., Shen Y.*, Bao, X. (2011). Effect of controlled overexpression of xylulokinase by different promoters on xylose metabolism in Saccharomyces cerevisiae. Acta Microbiologica Sinica, 51(7) :914-922. (in Chinese)

18. Shen, Y., Zhang, Y., Ma, T., Bao, X.*, Du, F., Zhuang, G., & Qu, Y. (2008). Simultaneous saccharification and fermentation of acid-pretreated corncobs with a recombinantSaccharomyces cerevisiae expressing beta-glucosidase. Bioresour Technol, 99(11), 5099-5103. doi: 10.1016/j.biortech.2007.09.046 (IF 5.651)

（上标1为共同第一作者，上标*为通讯作者）

Patents

(1) Xiaoming Bao, Yu Shen, Ruilei Ge. Nucleic acid molecule encoding xylose isomerase and xylose isomerase encoded thereof，2016.03.16，EP 2679686 B1

(2) Xiaoming Bao, Yu Shen, Ruilei Ge. Nucleic acid molecule encoding xylose isomerase and xylose isomerase encoded by the nucleic acid molecule，2013.11.19，US 8586336 B2

(3) Yu Shen, Xiaoming Bao, Wenyan Huo, Huaiwei Liu. An xylose utilizing Saccharomyces cerevisiae，2013.01.15，ZL 201210088133.X

(4)Xiaoming Bao, Yu Shen, Ruilei Ge. Nucleic acid molecule encoding xylose isomerase and xylose isomerase encoded by the nucleic acid molecule，2012.10.10，ZL 201110042170.2